Search Results - "Spadari, S."

Thymidine phosphorylase: a two-face Janus in anticancer chemotherapy by Focher, F, Spadari, S

“…Several cytokines and growth factors modulate angiogenesis through a fine tuned paracrine or autocrine mode of action. Among them is plateled-derived…”
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Quinoxalinylethylpyridylthioureas (QXPTs) as Potent Non-Nucleoside HIV-1 Reverse Transcriptase (RT) Inhibitors. Further SAR Studies and Identification of a Novel Orally Bioavailable Hydrazine-Based Antiviral Agent by Campiani, Giuseppe, Aiello, Francesca, Fabbrini, Monica, Morelli, Elena, Ramunno, Anna, Armaroli, Silvia, Nacci, Vito, Garofalo, Antonio, Greco, Giovanni, Novellino, Ettore, Maga, Giovanni, Spadari, Silvio, Bergamini, Alberto, Ventura, Laura, Bongiovanni, Barbara, Capozzi, Marcella, Bolacchi, Francesca, Marini, Stefano, Coletta, Massimiliano, Guiso, Giovanna, Caccia, Silvio

“…Quinoxalinylethylpyridylthioureas (QXPTs) represent a new class of human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase (RT)…”
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HIV-1 reverse transcriptase inhibitors: current issues and future perspectives by Locatelli, G A, Cancio, R, Spadari, S, Maga, G

“…One of the major advances in the recent history of the treatment of HIV infections has been the development of different classes of effective antiretroviral…”
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Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases β and λ by Crespan, Emmanuele, Zanoli, Samantha, Khandazhinskaya, Anastasiya, Shevelev, Igor, Jasko, Maxim, Alexandrova, Ludmila, Kukhanova, Marina, Blanca, Giuseppina, Villani, Giuseppe, Hübscher, Ulrich, Spadari, Silvio, Maga, Giovanni

“…A novel class of non-nucleoside triphosphate analogues, bearing hydrophobic groups sterically similar to nucleosides linked to the α-phosphate but lacking the…”
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Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells by Locatelli, Giada A, Di Santo, Roberto, Crespan, Emmanuele, Costi, Roberta, Roux, Alessandra, Hübscher, Ulrich, Shevelev, Igor, Blanca, Giuseppina, Villani, Giuseppe, Spadari, Silvio, Maga, Giovanni

“…Mammalian terminal deoxyribonucleotidyl transferase (TDT) catalyzes the non-template-directed polymerization of deoxyribonucleoside triphosphates and has a key…”
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Lack of enantioselectivity of herpes virus thymidine kinase allows safer imaging of gene delivery by MAGRASSI, L, FINOCCHIARO, G, MILANESI, G, BENVENUTO, F, SPADARI, S, FOCHER, F

“…Herpes simplex virus thymidine kinase (HSV-TK) is widely used in gene therapy. The enzymatic activity of HSV-TK may be traced in vivo by specific…”
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DNA replication and chemotherapy by Hübscher, U, Spadari, S

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Potentiation of Inhibition of Wild-Type and Mutant Human Immunodeficiency Virus Type 1 Reverse Transcriptases by Combinations of Nonnucleoside Inhibitors and d- and l-(β)-Dideoxynucleoside Triphosphate Analogs by MAGA, Giovanni, HÜBSCHER, Ulrich, PREGNOLATO, Massimo, UBIALI, Daniela, GOSSELIN, Gilles, SPADARI, Silvio

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes by Verri, A, Focher, F, Duncombe, R J, Basnak, I, Walker, R T, Coe, P L, de Clercq, E, Andrei, G, Snoeck, R, Balzarini, J, Spadari, S

“…The antiviral activity of several nucleoside analogues is often limited by their rapid degradation by pyrimidine nucleoside phosphorylases. In an attempt to…”
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Uracil-DNA glycosylases preferentially excise mispaired uracil by VERRI, A, MAZZARELLO, P, SPADARI, S, FOCHER, F

“…We have investigated the substrate specificity of human, viral and bacterial uracil-DNA glycosylases employing as substrate double-stranded oligonucleotides…”
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EUKARYOTIC DNA POLYMERASES by Hübscher, Ulrich, Maga, Giovanni, Spadari, Silvio

“…Any living cell is faced with the fundamental task of keeping the genome intact in order to develop in an organized manner, to function in a complex…”
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5-Iodo-2'-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2'-deoxy-L-uridine: selective phosphorylation by herpes simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies by Spadari, S, Ciarrocchi, G, Focher, F, Verri, A, Maga, G, Arcamone, F, Iafrate, E, Manzini, S, Garbesi, A, Tondelli, L

“…5-Iodo-2'-deoxy-L-uridine (L-IdU) and (E)-5-(2-bromovinyl)-2'-deoxy-L-uridine (L-BVdU) have been prepared and found to inhibit herpes simplex virus type 1…”
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Herpes simplex virus type 1 uracil-DNA glycosylase : isolation and selective inhibition by novel uracil derivatives by FOCHER, F, VERRI, A, SPADARI, S, MANSERVIGI, R, GAMBINO, J, WRIGHT, G. E

“…We have purified Herpes simplex type 1 (HSV1) uracil-DNA glycosylase from the nuclei of HSV1-infected HeLa cells harvested 8 h post-infection, at which time…”
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Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis and Biological Evaluation of Novel Quinoxalinylethylpyridylthioureas as Potent Antiviral Agents by Campiani, G, Fabbrini, M, Morelli, E, Nacci, V, Greco, G, Novellino, E, Maga, G, Spadari, S, Bergamini, A, Faggioli, E, Uccella, I, Bolacchi, F, Marini, S, Coletta, M, Fracasso, C, Caccia, S

“…New heterocyclic derivatives of ethylpyridylthiourea, quinoxalinylethylpyridylthiourea (QXPT) and analogues, inhibited human immunodeficiency virus type 1…”
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Correlation between anthracycline structure and human DNA ligase inhibition by CIARROCCHI, G, LESTINGI, M, FONTANA, M, SPADARI, S, MONTECUCCO, A

“…A total of 19 anthracycline derivatives were tested for their ability to interfere in vitro with the action of the human replicative DNA ligase. Only those…”
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Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: Molecular basis for the antiviral activity of unnatural l-β-nucleosides by Spadari, S., Maga, G., Verri, A., Bendiscioli, A., Tondelli, L., Capobianco, M., Colonna, F., Garbesi, A., Focher, F.

“…Among enzymes involved in the synthesis of nucleotides and DNA, some exceptions have recently been found to the universal rule that enzymes act only on one…”
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Functional Roles of DNA Polymerases β and γ by Hübscher, Ulrich, Kuenzle, Clive C., Spadari, Silvio

“…The physiological functions of DNA polymerases (deoxynucleosidetriphosphate:DNA deoxynucleotidyltransferase, EC 2.7.7.7) β and γ were investigated by using…”
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Herpes Simplex Virus Type 1 (HSV-1) Uracil-DNA Glycosylase: Functional Expression in Escherichia coli, Biochemical Characterization, and Selective Inhibition by 6-( p-n-Octylanilino)Uracil by Argnani, R., Focher, F., Zucchini, S., Verri, A., Wright, G.E., Spadari, S., Manservigi, R.

“…The Herpes simplex virus type 1 (HSV-1) uracil-DNA glycosylase (UDG) is encoded by the UL2 gene. The translation from the first putative start codon of UL2…”
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SYNTHESIS AND IN VITRO ACTIVITY OF D- AND L-ENANTIOMERS OF 5-(TRIFLUOROMETHYL)URACIL NUCLEOSIDE DERIVATIVES by Salvetti, Raul, Pregnolato, Massimo, Verri, Annalisa, Focher, Federico, Spadari, Silvio, Marchand, Arnaud, Mathé, Christophe, Gosselin, Gilles

“…Recently, β-L-nucleoside analogues have emerged as a new class of sugar modified nucleosides with potential antiviral and/or antitumoral activity. As a part of…”
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Mechanism of inhibition of herpes simplex virus and vaccinia virus DNA polymerases by aphidicolin, a highly specific inhibitor of DNA replication in eucaryotes by G Pedrali-Noy, S Spadari

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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