Search Results - "Spaapen, Robbert"

An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport by Jongsma, Marlieke L.M., Berlin, Ilana, Wijdeven, Ruud H.M., Janssen, Lennert, Janssen, George M.C., Garstka, Malgorzata A., Janssen, Hans, Mensink, Mark, van Veelen, Peter A., Spaapen, Robbert M., Neefjes, Jacques

“…Through a network of progressively maturing vesicles, the endosomal system connects the cell’s interior with extracellular space. Intriguingly, this network…”
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The regulatory network behind MHC class I expression by Jongsma, Marlieke L.M., Guarda, Greta, Spaapen, Robbert M.

“…•The NLR family member NLRC5 is a regulator of MHC class I transcription.•The knowledge on the mechanisms behind basal MHC class I transcription is very…”
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Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma by Scanu, Tiziana, Spaapen, Robbert M., Bakker, Jeroen M., Pratap, Chandra Bhan, Wu, Lin-en, Hofland, Ingrid, Broeks, Annegien, Shukla, Vijay Kumar, Kumar, Mohan, Janssen, Hans, Song, Ji-Ying, Neefjes-Borst, E. Andra, te Riele, Hein, Holden, David W., Nath, Gopal, Neefjes, Jacques

“…Cancer is fueled by deregulation of signaling pathways in control of cellular growth and proliferation. These pathways are also targeted by infectious…”
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The Role of Glycosphingolipids in Immune Cell Functions by Zhang, Tao, de Waard, Antonius A, Wuhrer, Manfred, Spaapen, Robbert M

“…Glycosphingolipids (GSLs) exhibit a variety of functions in cellular differentiation and interaction. Also, they are known to play a role as receptors in…”
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Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment by Gajewski, Thomas F, Woo, Seng-Ryong, Zha, Yuanyuan, Spaapen, Robbert, Zheng, Yan, Corrales, Leticia, Spranger, Stefani

“…Highlights ► A T cell-inflamed tumor microenvironment may be predictive of response to immunotherapies. ► Non-inflamed tumors may require interventions…”
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Structure of an MHC I–tapasin–ERp57 editing complex defines chaperone promiscuity by Müller, Ines Katharina, Winter, Christian, Thomas, Christoph, Spaapen, Robbert M., Trowitzsch, Simon, Tampé, Robert

“…Adaptive immunity depends on cell surface presentation of antigenic peptides by major histocompatibility complex class I (MHC I) molecules and on stringent ER…”
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Dendritic cells can prime anti-tumor CD8+ T cell responses through major histocompatibility complex cross-dressing by MacNabb, Brendan W., Chen, Xiufen, Tumuluru, Sravya, Godfrey, James, Kasal, Darshan N., Yu, Jovian, Jongsma, Marlieke L.M., Spaapen, Robbert M., Kline, Douglas E., Kline, Justin

“…Antigen cross-presentation, wherein dendritic cells (DCs) present exogenous antigen on major histocompatibility class I (MHC-I) molecules, is considered the…”
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Soluble FAS Ligand Enhances Suboptimal CD40L/IL-21–Mediated Human Memory B Cell Differentiation into Antibody-Secreting Cells by van Asten, Saskia D., Unger, Peter-Paul, Marsman, Casper, Bliss, Sophie, Jorritsma, Tineke, Thielens, Nicole M., van Ham, S. Marieke, Spaapen, Robbert M.

“…Abstract Differentiation of Ag-specific B cells into class-switched, high-affinity, Ab-secreting cells provides protection against invading pathogens but is…”
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An unexplored angle: T cell antigen discoveries reveal a marginal contribution of proteasome splicing to the immunogenic MHC class I antigen pool by Verkerk, Tamara, Koomen, Sofie J. I., Fuchs, Kyra J., Griffioen, Marieke, Spaapen, Robbert M.

“…In the current era of T cell–based immunotherapies, it is crucial to understand which types of MHC-presented T cell antigens are produced by tumor cells. In…”
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Secretome Screening Reveals Fibroblast Growth Factors as Novel Inhibitors of Viral Replication by van Asten, Saskia D, Raaben, Matthijs, Nota, Benjamin, Spaapen, Robbert M

“…Cellular antiviral programs can efficiently inhibit viral infection. These programs are often initiated through signaling cascades induced by secreted…”
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The Connection Between Minor H Antigens and Neoantigens and the Missing Link in Their Prediction by Mutis, Tuna, Xagara, Anastasia, Spaapen, Robbert M

“…For hundreds of thousands of years, the human genome has extensively evolved, resulting in genetic variations in almost every gene. Immunological reflections…”
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Viral immune evasins impact antigen presentation by allele-specific trapping of MHC I at the peptide-loading complex by Sethumadhavan, Sunesh, Barth, Marie, Spaapen, Robbert M., Schmidt, Carla, Trowitzsch, Simon, Tampé, Robert

“…Major histocompatibility complex class I (MHC I) molecules present antigenic peptides to cytotoxic T cells to eliminate infected or cancerous cells. The…”
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Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment by Gajewski, Thomas F, Fuertes, Mercedes, Spaapen, Robbert, Zheng, Yan, Kline, Justin

“…The molecular identification of tumor antigens initially catalyzed substantial enthusiasm for the development of tumor antigen-based vaccines for the treatment…”
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Dendritic cells can prime anti-tumor CD8+ T cell responses through major histocompatibility complex cross-dressing by MacNabb, Brendan W., Chen, Xiufen, Tumuluru, Sravya, Godfrey, James, Kasal, Darshan N., Yu, Jovian, Jongsma, Marlieke L.M., Spaapen, Robbert M., Kline, Douglas E., Kline, Justin

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Isolation and expansion of pure and functional γδ T cells by Verkerk, Tamara, Pappot, Anouk T, Jorritsma, Tineke, King, Lisa A, Duurland, Mariël C, Spaapen, Robbert M, van Ham, S Marieke

“…γδ T cells are important components of the immune system due to their ability to elicit a fast and strong response against infected and transformed cells…”
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Therapeutic activity of high-dose intratumoral IFN-β requires direct effect on the tumor vasculature by Spaapen, Robbert M, Leung, Michael Y K, Fuertes, Mercedes B, Kline, Justin P, Zhang, Long, Zheng, Yan, Fu, Yang-Xin, Luo, Xixi, Cohen, Kenneth S, Gajewski, Thomas F

“…Endogenous type I IFN production after innate immune recognition of tumor cells is critical for generating natural adaptive immune responses against tumors in…”
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Glycosphingolipid-Glycan Signatures of Acute Myeloid Leukemia Cell Lines Reflect Hematopoietic Differentiation by Wang, Di, Zhang, Tao, Madunić, Katarina, de Waard, Antonius A, Blöchl, Constantin, Mayboroda, Oleg A, Griffioen, Marieke, Spaapen, Robbert M, Huber, Christian G, Lageveen-Kammeijer, Guinevere S.M, Wuhrer, Manfred

“…Aberrant expression of certain glycosphingolipids (GSLs) is associated with the differentiation of acute myeloid leukemia (AML) cells. However, the expression…”
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Functional characteristics of the high affinity IgG receptor, FcγRI by van der Poel, Cees E, Spaapen, Robbert M, van de Winkel, Jan G J, Leusen, Jeanette H W

“…IgG FcRs are important mediators of immunity and play a key role during Ab-based immunotherapy. Within the leukocyte IgG receptor family, only FcγRI is capable…”
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CRISPR/Cas9 generated human CD46, CD55 and CD59 knockout cell lines as a tool for complement research by Thielen, Astrid J.F., van Baarsen, Iris M., Jongsma, Marlieke L., Zeerleder, Sacha, Spaapen, Robbert M., Wouters, Diana

“…To prevent unwanted complement activation and subsequent damage, complement activation must be tightly regulated on healthy host cells. Dysregulation of the…”
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Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning by Gerke, Carolin, Bauersfeld, Liane, Schirmeister, Ivo, Mireisz, Chiara Noemi-Marie, Oberhardt, Valerie, Mery, Lea, Wu, Di, Jürges, Christopher Sebastian, Spaapen, Robbert M, Mussolino, Claudio, Le-Trilling, Vu Thuy Khanh, Trilling, Mirko, Dölken, Lars, Paster, Wolfgang, Erhard, Florian, Hofmann, Maike, Schlosser, Andreas, Hengel, Hartmut, Momburg, Frank, Halenius, Anne

“…Human leucocyte antigen class I (HLA-I) molecules play a central role for both NK and T-cell responses that prevent serious human cytomegalovirus (HCMV)…”
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