Search Results - "Spaan, Michelle"

Immunological Analysis During Interferon-Free Therapy for Chronic Hepatitis C Virus Infection Reveals Modulation of the Natural Killer Cell Compartment by Spaan, Michelle, van Oord, Gertine, Kreefft, Kim, Hou, Jun, Hansen, Bettina E., Janssen, Harry L. A., de Knegt, Robert J., Boonstra, Andre

“…Background. Chronic hepatitis C virus (HCV) infection is a global health problem, resulting in liver failure, hepatocellular carcinoma, and liver-related…”
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Frequencies of Circulating MAIT Cells Are Diminished in Chronic HCV, HIV and HCV/HIV Co-Infection and Do Not Recover during Therapy by Spaan, Michelle, Hullegie, Sebastiaan J, Beudeker, Boris J B, Kreefft, Kim, van Oord, Gertine W, Groothuismink, Zwier M A, van Tilborg, Marjolein, Rijnders, Bart, de Knegt, Robert J, Claassen, Mark A A, Boonstra, Andre

“…Mucosal-associated invariant T (MAIT) cells comprise a subpopulation of T cells that can be activated by bacterial products and cytokines to produce IFN-γ…”
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Immunology of hepatitis C virus infections by Spaan, Michelle, MD, Janssen, Harry L.A., MD, PhD, Boonstra, Andre, PhD

“…Abstract The immune response in patients chronically infected with HCV plays a unique role during the infection because of its potential to contribute not only…”
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Hepatitis delta genotype 5 is associated with favourable disease outcome and better response to treatment compared to genotype 1 by Spaan, Michelle, Carey, Ivana, Bruce, Matthew, Shang, Dazhuang, Horner, Mary, Dusheiko, Geoff, Agarwal, Kosh

“…Coinfection with HDV causes rapid progression to liver cirrhosis and hepatic decompensation in patients with chronic hepatitis B. Factors that are associated…”
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Adverse outcomes following transjugular intrahepatic portosystemic shunt placement in relation to the underlying cause of portal hypertension by Van der Meer, Adriaan, Spaan, Michelle, Moelker, Adriaan, Dijkstra, Willemijn, Werner, Ellen, Bijdevaate, Diederik, Geeraedts, Tychon, Sonneveld, Milan, Coenen, Sandra, Sprengers, Dave, De Man, Robert, Maan, Raoel, Murad, Sarwa Darwish

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SAT-536 - Adverse outcomes following transjugular intrahepatic portosystemic shunt placement in relation to the underlying cause of portal hypertension by Van der Meer, Adriaan, Spaan, Michelle, Moelker, Adriaan, Dijkstra, Willemijn, Werner, Ellen, Bijdevaate, Diederik, Geeraedts, Tychon, Sonneveld, Milan, Coenen, Sandra, Sprengers, Dave, De Man, Robert, Maan, Raoel, Murad, Sarwa Darwish

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FRI-367 Prediction of hepatocellular carcinoma risk and liver-related events in chronic hepatitis D, an international retrospective cohort study (RIDE) by Patmore, Lesley A., Spaan, Michelle, Agarwal, Kosh, Koc, Ozgur, Blokzijl, Hans, Brouwer, Samantha, van Soest, Hanneke, van Hulzen, Astrid, Janssen, Harry L.A., Lammers, Jolanda, Jansen, Louis, Claassen, Mark, de Man, Robert A., Takkenberg, R. Bart, van Dijk, Remco, Posthouwer, Dirk, Reijnders, Jurriën, Carey, Ivana, Sonneveld, Milan J.

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Prediction of Hepatocellular Carcinoma and Liver-related Events in Anti-hepatitis D Virus-positive Individuals by Patmore, Lesley A., Spaan, Michelle, Agarwal, Kosh, Koc, Özgür M., Blokzijl, Hans, Brouwer, Samantha, van Soest, Hanneke, van Hulzen, Astrid G.W., Janssen, Harry L.A., Lammers, A.J. Jolanda, Jansen, Louis, Claassen, Mark, de Man, Robert A., Takkenberg, R. Bart, van Dijk, Remco, Posthouwer, Dirk, Reijnders, Jurriën G.P., Carey, Ivana, Sonneveld, Milan J.

“…Chronic hepatitis D (CHD) is the most severe form of chronic viral hepatitis, with a high risk of developing hepatocellular carcinoma (HCC) and liver-related…”
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CD4+ CXCR5+ T cells in chronic HCV infection produce less IL-21, yet are efficient at supporting B cell responses by Spaan, Michelle, Kreefft, Kim, de Graav, Gretchen N, Brouwer, Willem P, de Knegt, Robert J, ten Kate, Fibo J.W, Baan, Carla C, Vanwolleghem, Thomas, Janssen, Harry L.A, Boonstra, Andre

“…Background & Aims During chronic HCV infection, T cell dependent virus-specific antibodies are produced. However, the role of B-T cell interaction in chronic…”
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The Intrahepatic T Cell Compartment Does Not Normalize Years After Therapy-Induced Hepatitis C Virus Eradication by Spaan, Michelle, Claassen, Mark A. A., Hou, Jun, Janssen, Harry L A., de Knegt, Robert J., Boonstra, Andre

“…Little is known about the immune status in liver and blood of patients with chronic hepatitis C virus (HCV) infection long after therapy-induced viral…”
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Prediction of hepatocellular carcinoma and liver-related events in anti-HDV positive individuals by Patmore, Lesley A, Spaan, Michelle, Agarwal, K, Koc, Özgür M, Blokzijl, Hans, Brouwer, Samantha, van Soest, Hanneke, van Hulzen, Astrid G W, Janssen, Harry L A, Lammers, A J Jolanda, Jansen, Louis, Claassen, Mark, de Man, Robert A, Takkenberg, R Bart, van Dijk, Remco, Posthouwer, Dirk, Reijnders, Jurriën G P, Carey, Ivana, Sonneveld, Milan J

“…Chronic hepatitis D (CHD) is the most severe form of chronic viral hepatitis, with a high risk of developing hepatocellular carcinoma (HCC) and liver-related…”
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Interleukin 15 upregulates the expression of PD-1 and TIM-3 on CD4+ and CD8+ T cells by Hakim, Mohamad S, Jariah, Rizka O A, Spaan, Michelle, Boonstra, Andre

“…Virus-specific T cell-mediated immunity is severely impaired in chronic hepatitis B virus (HBV) patients. HBV-specific T cells in chronic HBV patients show a…”
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Longitudinal analysis of peripheral and intrahepatic NK cells in chronic HCV patients during antiviral therapy by Spaan, Michelle, van Oord, Gertine W., Janssen, Harry L.A., de Knegt, Robert J., Boonstra, Andre

“…•NK cells are important in the defense against viral infections.•Fine needle aspiration biopsies are a valuable tool to longitudinally characterize the…”
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Healthy human salivary glands contain a DHEA‐sulphate processing intracrine machinery, which is deranged in primary Sjögren's syndrome by Spaan, Michelle, Porola, Pauliina, Laine, Mikael, Rozman, Blaz, Azuma, Masayuki, Konttinen, Yrjö T.

“…Sjögren's syndrome (SS) patients have low salivary dehydroepiandrosterone (DHEA) and androgen biomarker levels, but high salivary oestrogen levels. The…”
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Inhibitory receptor molecules in chronic hepatitis B and C infections: novel targets for immunotherapy? by Hakim, Mohamad S., Spaan, Michelle, Janssen, Harry L. A., Boonstra, Andre

“…SUMMARY Chronic HBV and HCV infections are the leading cause of liver‐related morbidity and mortality. For effective antiviral immunity, virus‐specific T cells…”
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Erythropoietin administration suppresses human monocyte function in vitro and during therapy-induced anemia in HCV patients by Spaan, Michelle, Groothuismink, Zwier M.A., Koning, Ludi, Roomer, Robert, Janssen, Harry L.A., De Knegt, Robert J., Boonstra, André

“…•Human monocytes express EPO receptor mRNA.•EPO inhibits IL-6 and TNF producing monocytes in vitro.•EPO increases phagocytic ability but does not alter ROS…”
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