Surgical correction of corneal opacity and aniridia with penetrating keratoplasty and a new iris prosthesis implant

Surgical correction of corneal opacity and aniridia with penetrating keratoplasty and a new iris prosthesis implant

Purpose This study is to describe the clinical outcome of penetrating keratoplasty combined with implantation of a novel intraocular lens with an artificial iris, aided by continuous vitreous chamber infusion, in patients with severe aniridia and corneal alterations. Methods This was a prospective s...

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Published in:Graefe's archive for clinical and experimental ophthalmology Vol. 261; no. 5; pp. 1331 - 1338
Main Authors: Villarrubia, Alberto, Sánchez Ventosa, Álvaro, Cubero Parra, Juan Manuel, Spínola Moreno, Consuelo, Laborda Oñate, Juan Manuel, Palacín Miranda, Elisa, González-Cruces, Timoteo, Morales López, Pablo, Cano-Ortiz, Antonio
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-05-2023
Springer Nature B.V
Subjects:
Acuity
Aniridia
Aniridia - complications
Aniridia - diagnosis
Aniridia - surgery
Cell density
Cornea
Corneal Opacity - surgery
Corneal transplantation
Endothelial cells
Eye surgery
Humans
Intraocular lenses
Iris
Iris - surgery
Keratoplasty, Penetrating - methods
Lens Implantation, Intraocular - methods
Lenses, Intraocular
Medicine
Medicine & Public Health
Myopia
Ophthalmology
Patients
Prospective Studies
Prostheses
Retrospective Studies
Visual acuity
Penetrating keratoplasty
Corneal opacity
Iris prosthesis implant
Aniridia
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Summary:Purpose This study is to describe the clinical outcome of penetrating keratoplasty combined with implantation of a novel intraocular lens with an artificial iris, aided by continuous vitreous chamber infusion, in patients with severe aniridia and corneal alterations. Methods This was a prospective single-center case series study involving five patients with corneal alterations and aniridia. All subjects underwent simultaneous penetrating keratoplasty and implantation of a new intraocular lens with an artificial iris with the assistance of infusion into the vitreous chamber to regulate intraocular pressure during the surgical procedure. Visual acuity, corneal endothelial cell density, and intraocular pressure assessments were performed in the postoperative period. The final cosmetic outcome of the iris prosthesis placement was also evaluated. Results In all cases, increased visual acuity and a good aesthetic result were observed in all affected eyes except one in which, despite the excellent aesthetic outcome, the eye was very hypotonic as it had high myopia and had undergone several previous surgeries. Conclusion The single surgical procedure combining implantation of an intraocular lens-iris prosthesis with penetrating keratoplasty is an effective technique for the simultaneous treatment of aphakia and aniridia. However, larger series with longer-term follow-up are needed to definitively establish the benefits of this technique.
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ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-022-05920-2