Search Results - "Späth, Daniela"

RUNX1 Mutations in Acute Myeloid Leukemia: Results From a Comprehensive Genetic and Clinical Analysis From the AML Study Group by GAIDZIK, Verena I, BULLINGER, Lars, SPÄTH, Daniela, KÜNDGEN, Andrea, SCHMIDT-WOLF, Ingo G. H, GOTZE, Katharina, NACHBAUR, David, PFREUNDSCHUH, Michael, HORST, Heinz A, DÖHNER, Hartmut, DÖHNER, Konstanze, SCHLENK, Richard F, ZIMMERMANN, Andreas S, RÖCK, Jürgen, PASCHKA, Peter, CORBACIOGLU, Andrea, KRAUTER, Jürgen, SCHLEGELBERGER, Brigitte, GANSER, Arnold

“…To evaluate frequency, biologic features, and clinical relevance of RUNX1 mutations in acute myeloid leukemia (AML). Diagnostic samples from 945 patients (age…”
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IDH1 and IDH2 Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With NPM1 Mutation Without FLT3 Internal Tandem Duplication by PASCHKA, Peter, SCHLENK, Richard F, HORST, Heinz-A, GERMING, Ulrich, DÖHNER, Hartmut, DÖHNER, Konstanze, GAIDZIK, Verena I, HABDANK, Marianne, KRÖNKE, Jan, BULLINGER, Lars, SPÄTH, Daniela, KAYSER, Sabine, ZUCKNICK, Manuela, GÖTZE, Katharina

“…To analyze the frequency and prognostic impact of isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) mutations in acute myeloid leukemia…”
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Acute Myeloid Leukemia (AML): Different Treatment Strategies Versus a Common Standard Arm—Combined Prospective Analysis by the German AML Intergroup by BÜCHNER, Thomas, SCHLENK, Richard F, SPÄTH, Daniela, KRAMER, Michael, SCHOLL, Sebastian, BERDEL, Wolfgang E, HIDDEMANN, Wolfgang, HOELZER, Dieter, HEHLMANN, Rüdiger, HASFORD, Joerg, HOFFMANN, Verena S, DÖHNER, Hartmut, SCHAICH, Markus, EHNINGER, Gerhard, GANSER, Arnold, NIEDERWIESER, Dietger W, PFIRRMANN, Markus, DÖHNER, Konstanze, KRAHL, Rainer, KRAUTER, Jürgen, HEIL, Gerhard, KRUG, Utz, SAUERLAND, Maria Cristina, HEINECKE, Achim

“…Identifying true therapeutic progress in patients with acute myeloid leukemia (AML) requires a comparison of treatment strategies and results on the basis of…”
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Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia by Krönke, Jan, Bullinger, Lars, Teleanu, Veronica, Tschürtz, Florian, Gaidzik, Verena I., Kühn, Michael W.M., Rücker, Frank G., Holzmann, Karlheinz, Paschka, Peter, Kapp-Schwörer, Silke, Späth, Daniela, Kindler, Thomas, Schittenhelm, Marcus, Krauter, Jürgen, Ganser, Arnold, Göhring, Gudrun, Schlegelberger, Brigitte, Schlenk, Richard F., Döhner, Hartmut, Döhner, Konstanze

“…Mutations in the nucleophosmin 1 (NPM1) gene are considered a founder event in the pathogenesis of acute myeloid leukemia (AML). To address the role of clonal…”
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Monitoring of Minimal Residual Disease in NPM1-Mutated Acute Myeloid Leukemia: A Study From the German-Austrian Acute Myeloid Leukemia Study Group by KRÖNKE, Jan, SCHLENK, Richard F, SPÄTH, Daniela, LÜBBERT, Michael, WATTAD, Mohammed, KINDLER, Thomas, SALIH, Helmut R, HELD, Gerhard, NACHBAUR, David, VON LILIENFELD-TOAL, Marie, GERMING, Ulrich, HAASE, Detlef, JENSEN, Kai-Ole, MERGENTHALER, Hans-Günther, KRAUTER, Jürgen, GANSER, Arnold, GÖHRING, Gudrun, SCHLEGELBERGER, Brigitte, DÖHNER, Hartmut, DÖHNER, Konstanze, TSCHÜRTZ, Florian, CORBACIOGLU, Andrea, GAIDZIK, Verena I, PASCHKA, Peter, ONKEN, Shiva, EIWEN, Karina, HABDANK, Marianne

“…To evaluate the prognostic value of minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) with NPM1 mutation (NPM1(mut)). RNA-based…”
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TET2 Mutations in Acute Myeloid Leukemia (AML): Results From a Comprehensive Genetic and Clinical Analysis of the AML Study Group by GAIDZIK, Verena I, PASCHKA, Peter, BENTZ, Martin, GÖTZE, Katharina, DÖHNER, Hartmut, SCHLENK, Richard F, BULLINGER, Lars, DÖHNER, Konstanze, SPÄTH, Daniela, HABDANK, Marianne, KÖHNE, Claus-Henning, GERMING, Ulrich, VON LILIENFELD-TOAL, Marie, HELD, Gerhard, HORST, Heinz-August, HAASE, Detlef

“…The tet oncogene family member 2 (TET2) gene was recently identified to be mutated in myeloid disorders including acute myeloid leukemia (AML). To date, there…”
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Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B by Schlenk, Richard F, Dohner, Konstanze, Kneba, Michael, Gotze, Katharina, Hartmann, Frank, del Valle, Francesco, Kirchen, Heinz, Koller, Elisabeth, Fischer, Jorg T, Bullinger, Lars, Habdank, Marianne, Spath, Daniela, Groner, Silja, Krebs, Bernhard, Kayser, Sabine, Corbacioglu, Andrea, Anhalt, Andreas, Benner, Axel, Frohling, Stefan, Dohner, Hartmut, German-Austrian AML Study Group (AMLSG)

“…1 Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany 2 Department of Internal Medicine II, University of Kiel, Kiel, Germany 3…”
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Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies by Kayser, Sabine, Zucknick, Manuela, Döhner, Konstanze, Krauter, Jürgen, Köhne, Claus-Henning, Horst, Heinz A., Held, Gerhard, von Lilienfeld-Toal, Marie, Wilhelm, Sibylla, Rummel, Mathias, Germing, Ulrich, Götze, Katharina, Nachbaur, David, Schlegelberger, Brigitte, Göhring, Gudrun, Späth, Daniela, Morlok, Carina, Teleanu, Veronica, Ganser, Arnold, Döhner, Hartmut, Schlenk, Richard F.

“…We aimed to determine the prognostic impact of monosomal karyotype (MK) in acute myeloid leukemia (AML) in the context of the current World Health Organization…”
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ASXL1 mutations in younger adult patients with acute myeloid leukemia: a study by the German-Austrian Acute Myeloid Leukemia Study Group by Paschka, Peter, Schlenk, Richard F, Gaidzik, Verena I, Herzig, Julia K, Aulitzky, Teresa, Bullinger, Lars, Späth, Daniela, Teleanu, Veronika, Kündgen, Andrea, Köhne, Claus-Henning, Brossart, Peter, Held, Gerhard, Horst, Heinz-A, Ringhoffer, Mark, Götze, Katharina, Nachbaur, David, Kindler, Thomas, Heuser, Michael, Thol, Felicitas, Ganser, Arnold, Döhner, Hartmut, Döhner, Konstanze

“…We studied 1696 patients (18 to 61 years) with acute myeloid leukemia for ASXL1 mutations and identified these mutations in 103 (6.1%) patients. ASXL1…”
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Sunitinib and Intensive Chemotherapy in Patients with Acute Myeloid Leukemia and Activating FLT3 Mutations: Results of the AMLSG 10-07 Study (ClinicalTrials.gov No. NCT00783653) by Fiedler, Walter, Kayser, Sabine, Kebenko, Maxim, Krauter, Jürgen, Salih, Helmut R., Götze, Katharina, Späth, Daniela, Göhring, Gudrun, Teleanu, Veronica, Döhner, Konstanze, Ganser, Arnold, Döhner, Hartmut, Schlenk, Richard F

“…Abstract 1483▪▪This icon denotes a clinically relevant abstract Activating FLT3 mutations including internal tandem duplications (FLT3-ITD) and tyrosine-kinase…”
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Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia by Schlenk, Richard F, Döhner, Konstanze, Döhner, Hartmut, Krauter, Jürgen, Fröhling, Stefan, Corbacioglu, Andrea, Bullinger, Lars, Habdank, Marianne, Späth, Daniela, Morgan, Michael, Benner, Axel, Schlegelberger, Brigitte, Heil, Gerhard, Ganser, Arnold

“…Almost half of patients with acute myeloid leukemia (AML) do not have detectable cytogenetic abnormalities. This study of more than 870 such patients…”
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Induction Therapy with Idarubicin and Etoposide Combined with Sequential or Concurrent Azacitidine In Patients with High-Risk Acute Myeloid Leukemia: Pilot-Phase of the AMLSG 12-09 Study by Rücker, Frank G., Stilgenbauer, Stephan, Bommer, Martin, Späth, Daniela, Mack, Silja, Döhner, Konstanze, Döhner, Hartmut, Schlenk, Richard F.

“…Abstract 2184 Treatment outcome in patients with cytogenetically and/or molecularly defined high-risk acute myeloid leukemia (AML) is dismal with low complete…”
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Azacitidine-Containing Induction Regimens Followed by Azacitidine Maintenance Therapy in High Risk Acute Myeloid Leukemia: First Results of the Randomized Phase-II AMLSG 12-09 Study (ClinicalTrials.gov No. NCT01180322) by Schlenk, Richard F, Herr, Wolfgang, Wulf, Gerald, Salih, Helmut R, Krauter, Jürgen, Derigs, Hans Guenter, Kündgen, Andrea, Ringhoffer, Mark, Martens, Uwe M., Hertenstein, Bernd, Griesshammer, Martin, Girschikofsky, Michael, Bernhard, Helga, Kersten, Jens, von Lilienfeld-Toal, Maria, Koller, Elisabeth, Lange, Elisabeth, Westermann, Jörg, Späth, Daniela, Göhring, Gudrun, Teleanu, Veronica, Benner, Axel, Döhner, Konstanze, Ganser, Arnold, Döhner, Hartmut

“…Abstract 412 A large proportion of patients are currently not eligible for genotype-adapted strategies in acute myeloid leukemia (AML), in particular those…”
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Assessment of Clonal Evolution in 42 AML with NPM1 Mutations by Molecular Characterization of Paired Diagnosis and Relapse Samples by Krönke, Jan, Bullinger, Lars, Rücker, Frank G., Gaidzik, Verena I., Kühn, Michael WM, Bezet, Karin, Teleanu, Veronica, Paschka, Peter, Späth, Daniela, Kindler, Thomas, Salih, Helmut R., Krauter, Jürgen, Ganser, Arnold, Göhring, Gudrun, Schlegelberger, Brigitte, Schlenk, Richard F., Döhner, Hartmut, Döhner, Konstanze

“…Abstract 237▪▪This icon denotes a clinically relevant abstract Mutations in the nucleophosmin 1 (NPM1) gene represent one of the most frequent gene mutations…”
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ASXL1 Mutations Predict for Resistance to Chemotherapy and Inferior Outcome in Younger Adult Patients with Acute Myeloid Leukemia (AML): A Study of the German-Austrian AMLSG by Paschka, Peter, Schlenk, Richard F., Herzig, Julia, Aulitzky, Teresa, Gaidzik, Verena I., Bullinger, Lars, Habdank, Marianne, Corbacioglu, Andrea, Späth, Daniela, Köhne, Claus-Henning, Kündgen, Andrea, von Lilienfeld-Toal, Marie, Held, Gerhard, Horst, Heinz A., Götze, Katharina, Bentz, Martin, Krauter, Jürgen, Ganser, Arnold, Döhner, Hartmut, Döhner, Konstanze

“…Abstract 412 Somatic mutations of the ASXL1 (Additional Sex Comb-Like 1) gene on chromosome 20q11.1 were identified in various myeloid malignancies with the…”
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DNMT3A mutations Predict for Inferior Outcome in NPM1-Wildtype and Molecular Unfavorable Cytogenetically-Normal Acute Myeloid Leukemia: A Study of the German-Austrian AMLSG by Gaidzik, Verena I., Schlenk, Richard F., Paschka, Peter, Stölzle, Anja, Corbacioglu, Andrea, Nachbaur, David, Kindler, Thomas, Burchardt, Alexander C., Salih, Helmut R., Mergenthaler, Hans-Günther, Salwender, Hans J., Späth, Daniela, Bullinger, Lars, Krauter, Juergen, Ganser, Arnold, Döhner, Hartmut, Döhner, Konstanze

“…Abstract 415▪▪This icon denotes a clinically relevant abstract Alteration of DNA methylation, a hallmark of epigenetic modification, is currently discussed as…”
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Prognostic Impact of Mutant to Wild-Type Ratio and Insertion Site in Acute Myeloid Leukemia with FLT3 Internal Tandem Duplication by Kayser, Sabine, Schlenk, Richard F, Krauter, Jürgen, Köhne, Claus-Henning, Germing, Ulrich, Held, Gerhard, Horst, Heinz A., Ringhoffer, Mark, von Lilienfeld-Toal, Marie, Rummel, Mathias J., Götze, Katharina, Nachbaur, David, Schlegelberger, Brigitte, Göhring, Gudrun, Salih, Helmut R, Martin, Hans, Herr, Wolfgang, Lübbert, Michael, Salwender, Hans-Jürgen, Erdmann, Patricia, Paschka, Peter, Gaidzik, Verena I., Teleanu, Veronica, Späth, Daniela, Ganser, Arnold, Fischer, Thomas, Döhner, Hartmut, Döhner, Konstanze

“…Abstract ▪785▪This icon denotes a clinically relevant abstract FLT3 internal tandem duplications (FLT3-ITD) occur in about 25% of acute myeloid leukemia (AML),…”
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Isocitrate Dehydrogenase Gene Mutations In Elderly Patients with Acute Myeloid Leukemia (AML) and Outcome After Treatment with All-Trans Retinoic Acid: A Study of the German-Austrian AML Study Group (AMSLG) by Paschka, Peter, Schlenk, Richard F., Ibañez, Mariam, Kagias, Alexandra, Bullinger, Lars, Gaidzik, Verena I., Späth, Daniela, Horst, Heinz A., Held, Gerhard, Bentz, Martin, Kremers, Stephan, Greil, Richard, Wattad, Mohammed, Brugger, Wolfram, Runde, Volker, Raghavachar, Aruna, Derigs, Hans-Guenter, Kirchen, Heinrich, Döhner, Hartmut, Döhner, Konstanze

“…Abstract 101 We have recently reported that mutations in isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) genes are present in ~16% of younger adults [<60 years…”
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Acute Myeloid Leukemia (AML): Prospective Comparison of Different Treatments with a Common Standard Treatment - A Study by the German AML Intergroup by Buchner, Thomas, Schlenk, Richard F., Schaich, Markus, Döhner, Konstanze, Krahl, Rainer, Krauter, Jrgen, Sauerland, Maria Cristina, Späth, Daniela, Kramer, Michael, Ganser, Arnold, Niederwieser, Dietger W, Ehninger, Gerhard, Berdel, Wolfgang E., Hiddemann, Wolfgang, Dohner, Hartmut, Hoelzer, Dieter, Hehlmann, Rdiger, Hoffmann, Verena, Pfirrmann, Markus

“…Abstract 2175 Eight years from the start of a cooperation among five multicenter study groups in Germany, and three years after entering the last patient we…”
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Prospective Phase III Trial of Valproic acid (VPA) In Combination with All-Trans Retinoic Acid (ATRA) and Intensive Induction Therapy for AML In Older Patients: The German-Austrian AMLSG 06-04 Study by Tassara, Michela, Hofer, eronika, Döhner, Konstanze, Lilienfeld-Toal, Marie, Held, Gerhard, Götze, Katharina, Horst, Heinz A., Wilhelm, Sibylla, Kremers, Stephan, Koller, Elisabeth, Späth, Daniela, Mack, Silja, Morlok, Carina, Göttlicher, Martin, Döhner, Hartmut, Schlenk, Richard F.

“…Abstract 185 Acute Myeloid Leukemia - Therapy, excluding Transplantation: Pediatric and Adult AML Therapy Treatment options in AML patients older than 60 years…”
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