Search Results - "Sozhamannan, Shanmuga"

Exception to the exception rule: synthetic and naturally occurring single chromosome Vibrio cholerae by Sozhamannan, Shanmuga, Waldminghaus, Torsten

“…Summary The genome of Vibrio cholerae, the etiological agent of cholera, is an exception to the single chromosome rule found in the vast majority of bacteria…”
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Comparison of the performance of an amplicon sequencing assay based on Oxford Nanopore technology to real-time PCR assays for detecting bacterial biodefense pathogens by Player, Robert, Verratti, Kathleen, Staab, Andrea, Bradburne, Christopher, Grady, Sarah, Goodwin, Bruce, Sozhamannan, Shanmuga

“…The state-of-the-art in nucleic acid based biodetection continues to be polymerase chain reaction (PCR), and many real-time PCR assays targeting biodefense…”
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The State of the Art in Biodefense Related Bacterial Pathogen Detection Using Bacteriophages: How It Started and How It's Going by Sozhamannan, Shanmuga, Hofmann, Edward R

“…Accurate pathogen detection and diagnosis is paramount in clinical success of treating patients. There are two general paradigms in pathogen detection:…”
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Genetic evidence for the interaction between Bacillus anthracis-encoded phage receptors and their cognate phage-encoded receptor binding proteins by Forrest, Samantha, Ton, Sarah, Sholes, Samantha L., Harrison, Sarah, Plaut, Roger D., Verratti, Kathleen, Wittekind, Michael, Ettehadieh, Elham, Necciai, Bryan, Sozhamannan, Shanmuga, Grady, Sarah L.

“…Bacteriophages such as γ and AP50c have been shown to infect strains of Bacillus anthracis with high specificity, and this feature has been exploited in the…”
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Novel High-Molecular-Weight, R-Type Bacteriocins of Clostridium difficile by Gebhart, Dana, Williams, Steven R, Bishop-Lilly, Kimberly A, Govoni, Gregory R, Willner, Kristin M, Butani, Amy, Sozhamannan, Shanmuga, Martin, David, Fortier, Louis-Charles, Scholl, Dean

“…Clostridium difficile causes one of the leading nosocomial infections in developed countries, and therapeutic choices are limited. Some strains of C. difficile…”
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Impact of template denaturation prior to whole genome amplification on gene detection in high GC-content species, Burkholderia mallei and B. pseudomallei by Taitt, Chris R, Leski, Tomasz A, Compton, Jaimee R, Chen, Amy, Berk, Kimberly L, Dorsey, Robert W, Sozhamannan, Shanmuga, Dutt, Dianne L, Vora, Gary J

“…In this study, we sought to determine the types and prevalence of antimicrobial resistance determinants (ARDs) in Burkholderia spp. strains using the…”
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Beyond the chromosome: the prevalence of unique extra-chromosomal bacteriophages with integrated virulence genes in pathogenic Staphylococcus aureus by Utter, Bryan, Deutsch, Douglas R, Schuch, Raymond, Winer, Benjamin Y, Verratti, Kathleen, Bishop-Lilly, Kim, Sozhamannan, Shanmuga, Fischetti, Vincent A

“…In Staphylococcus aureus, the disease impact of chromosomally integrated prophages on virulence is well described. However, the existence of extra-chromosomal…”
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Functionality of Two Origins of Replication in Vibrio cholerae Strains With a Single Chromosome by Bruhn, Matthias, Schindler, Daniel, Kemter, Franziska S, Wiley, Michael R, Chase, Kitty, Koroleva, Galina I, Palacios, Gustavo, Sozhamannan, Shanmuga, Waldminghaus, Torsten

“…Chromosomal inheritance in bacteria usually entails bidirectional replication of a single chromosome from a single origin into two copies and subsequent…”
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A Survey of Antimicrobial Resistance Determinants in Category A Select Agents, Exempt Strains, and Near-Neighbor Species by Taitt, Chris R, Leski, Tomasz A, Chen, Amy, Berk, Kimberly L, Dorsey, Robert W, Gregory, Michael J, Sozhamannan, Shanmuga, Frey, Kenneth G, Dutt, Diane L, Vora, Gary J

“…A dramatic increase in global antimicrobial resistance (AMR) has been well documented. Of particular concern is the dearth of information regarding the…”
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Wastewater Surveillance Pilot at US Military Installations: Cost Model Analysis by Sanjak, Jaleal S, McAuley, Erin M, Raybern, Justin, Pinkham, Richard, Tarnowski, Jacob, Miko, Nicole, Rasmussen, Bridgette, Manalo, Christian J, Goodson, Michael, Stamps, Blake, Necciai, Bryan, Sozhamannan, Shanmuga, Maier, Ezekiel J

“…The COVID-19 pandemic highlighted the need for pathogen surveillance systems to augment both early warning and outbreak monitoring/control efforts. Community…”
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Standards for sequencing viral genomes in the era of high-throughput sequencing by Ladner, Jason T, Beitzel, Brett, Chain, Patrick S G, Davenport, Matthew G, Donaldson, Eric F, Frieman, Matthew, Kugelman, Jeffrey R, Kuhn, Jens H, O'Rear, Jules, Sabeti, Pardis C, Wentworth, David E, Wiley, Michael R, Yu, Guo-Yun, Sozhamannan, Shanmuga, Bradburne, Christopher, Palacios, Gustavo

“…Thanks to high-throughput sequencing technologies, genome sequencing has become a common component in nearly all aspects of viral research; thus, we are…”
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Development, testing and validation of a SARS-CoV-2 multiplex panel for detection of the five major variants of concern on a portable PCR platform by Stanhope, Bryce J, Peterson, Brittany, Knight, Brittany, Decadiz, Ray Nobles, Pan, Roger, Davis, Phillip, Fraser, Anne, Nuth, Manunya, vanWestrienen, Jesse, Wendlandt, Erik, Goodwin, Bruce, Myers, Christopher, Stone, Jennifer, Sozhamannan, Shanmuga

“…Many SARS-CoV-2 variants have emerged during the course of the COVID-19 pandemic. These variants have acquired mutations conferring phenotypes such as…”
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Genomic characterization of the Yersinia genus by Chen, Peter E, Cook, Christopher, Stewart, Andrew C, Nagarajan, Niranjan, Sommer, Dan D, Pop, Mihai, Thomason, Brendan, Thomason, Maureen P Kiley, Lentz, Shannon, Nolan, Nichole, Sozhamannan, Shanmuga, Sulakvelidze, Alexander, Mateczun, Alfred, Du, Lei, Zwick, Michael E, Read, Timothy D

“…New DNA sequencing technologies have enabled detailed comparative genomic analyses of entire genera of bacterial pathogens. Prior to this study, three species…”
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Impact of SARS-CoV-2 Mutations on PCR Assay Sequence Alignment by Negrón, Daniel Antonio, Kang, June, Mitchell, Shane, Holland, Mitchell Y, Wist, Stephen, Voss, Jameson, Brinkac, Lauren, Jennings, Katharine, Guertin, Stephanie, Goodwin, Bruce G, Sozhamannan, Shanmuga

“…Real-time reverse transcription polymerase chain reaction (RT-PCR) assays are the most widely used molecular tests for the detection of SARS-CoV-2 and…”
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Genetic Evidence for the Involvement of the S-Layer Protein Gene sap and the Sporulation Genes spo0A, spo0B, and spo0F in Phage AP50c Infection of Bacillus anthracis by Plaut, Roger D, Beaber, John W, Zemansky, Jason, Kaur, Ajinder P, George, Matroner, Biswas, Biswajit, Henry, Matthew, Bishop-Lilly, Kimberly A, Mokashi, Vishwesh, Hannah, Ryan M, Pope, Robert K, Read, Timothy D, Stibitz, Scott, Calendar, Richard, Sozhamannan, Shanmuga

“…In order to better characterize the Bacillus anthracis typing phage AP50c, we designed a genetic screen to identify its bacterial receptor. Insertions of the…”
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Avirulent Bacillus anthracis Strain with Molecular Assay Targets as Surrogate for Irradiation-Inactivated Virulent Spores by Plaut, Roger D, Staab, Andrea B, Munson, Mark A, Gebhardt, Joan S, Klimko, Christopher P, Quirk, Avery V, Cote, Christopher K, Buhr, Tony L, Rossmaier, Rebecca D, Bernhards, Robert C, Love, Courtney E, Berk, Kimberly L, Abshire, Teresa G, Rozak, David A, Beck, Linda C, Stibitz, Scott, Goodwin, Bruce G, Smith, Michael A, Sozhamannan, Shanmuga

“…The revelation in May 2015 of the shipment of γ irradiation-inactivated wild-type Bacillus anthracis spore preparations containing a small number of live…”
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Scanning the landscape of genome architecture of non-O1 and non-O139 Vibrio cholerae by whole genome mapping reveals extensive population genetic diversity by Chapman, Carol, Henry, Matthew, Bishop-Lilly, Kimberly A, Awosika, Joy, Briska, Adam, Ptashkin, Ryan N, Wagner, Trevor, Rajanna, Chythanya, Tsang, Hsinyi, Johnson, Shannon L, Mokashi, Vishwesh P, Chain, Patrick S G, Sozhamannan, Shanmuga

“…Historically, cholera outbreaks have been linked to V. cholerae O1 serogroup strains or its derivatives of the O37 and O139 serogroups. A genomic study on the…”
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Halo-A Universal Fluorescence Reader Based Threat Agent Detection Platform-A Proof of Concept Study Using SARS-CoV-2 Assays by Walish, Joseph, Cox, Jason, Boone, Jeremy, Stone, Jennifer, Henderson, Nathan, Maloney, Molly, Ma, Joe, Maa, Jonathan, On, Nghiem, Petre, Konrad, Goodwin, Bruce G, Sozhamannan, Shanmuga, Deans, Robert

“…Polymerase chain reaction (PCR) remains the gold standard in disease diagnostics due to its extreme sensitivity and specificity. However, PCR tests are…”
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Reorganized Genomic Taxonomy of Francisellaceae Enables Design of Robust Environmental PCR Assays for Detection of Francisella tularensis by Öhrman, Caroline, Sahl, Jason W, Sjödin, Andreas, Uneklint, Ingrid, Ballard, Rebecca, Karlsson, Linda, McDonough, Ryelan F, Sundell, David, Soria, Kathleen, Bäckman, Stina, Chase, Kitty, Brindefalk, Björn, Sozhamannan, Shanmuga, Vallesi, Adriana, Hägglund, Emil, Ramirez-Paredes, Jose Gustavo, Thelaus, Johanna, Colquhoun, Duncan, Myrtennäs, Kerstin, Birdsell, Dawn, Johansson, Anders, Wagner, David M, Forsman, Mats

“…In recent years, an increasing diversity of species has been recognized within the family . Unfortunately, novel isolates are sometimes misnamed in initial…”
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Blind Spot: A Braille Patterned Novel Multiplex Lateral Flow Immunoassay Sensor Array for the Detection of Biothreat Agents by Hofmann, E. Randal, Davidson, Charles, Chen, Hsiu, Zacharko, Melody, Dorton, Jay E, Kilper, Gary K, Graves, Carcie, Miklos, Aleksandr E, Rhea, Katherine, Ma, Joe, Goodwin, Bruce G, Sozhamannan, Shanmuga

“…Lateral flow immunoassays (LFIs) are simple, point-of-care diagnostic devices used for detecting biological agents or other analytes of interest in a sample…”
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