Search Results - "Sozaeva, Z A"
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Effect of ABCB1 Gene Carriage and Drug-Drug Interactions on Apixaban and Rivaroxaban Pharmacokinetics and Clinical Outcomes in Patients with Atrial Fibrillation and Deep Vein Thrombosis
Published in Rat͡s︡ionalʹnai͡a︡ farmakoterapii͡a︡ v kardiologii (06-01-2023)“…Aim . To investigate the effect of ABCB1 gene carriage and interdrug interactions on apixaban pharmacokinetics and clinical outcomes in patients with atrial…”
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Pharmacogenetic Aspects of Postoperative Anesthesia with Ketoprofen in Cardiac Surgery Patients
Published in Rat͡s︡ionalʹnai͡a︡ farmakoterapii͡a︡ v kardiologii (03-11-2021)“…Aim. Evaluation of the effect of polymorphisms of the CYP2D6, CYP2C8 genes on the efficacy and safety of postoperative analgesia with ketoprofen in patients…”
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Predictive modeling of adverse events of tamoxifen therapy for breast cancer (results of a cohort study)
Published in Farmakogenetika i farmakogenomika (27-02-2023)“…Relevance. Endocrine therapy is the standard treatment for women with ER-positive breast cancer. The clinical response to Tamoxifen is variable. Approximately…”
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CYP2D6 gene polymorphic markers role in determining the optimal treatment tactics for portal hypertension in patients with liver cirrhosis
Published in Terapevtic̆eskii arhiv (15-02-2022)“…Aim. To study the polymorphic markers CYP2D6*4 (G1846A, rs3892097), CYP2D6*6 (T1707del, rs5030655), CYP2D6*10 (C100T, rs1065852), CYP2D6*41 (G2988A,…”
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Evaluation of the association of polymorphisms of the CYP2C8 gene with the efficacy and safety of ketorolac in patients with postoperative pain syndrome
Published in Terapevtic̆eskii arhiv (17-06-2022)“…Aim. To evaluate the possible association of CYP2C8 gene polymorphisms with the clinical efficacy and safety of ketorolac in relation to postoperative pain…”
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CYP2C8, PTGS-1, 2 gene polymorphisms prevalence associated with sensitivity to non-steroidal anti-inflammatory drugs among North Caucasus ethnic groups
Published in Terapevtic̆eskii arhiv (15-11-2021)“…Aim. Find the prevalence of CYP2C8*3 (rs10509681; rs11572080), PTGS-1 (rs10306135; rs12353214) and PTGS-2 (rs20417) alleles and genotypes in four ethnic groups…”
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Analysis of carrying clinically significant allelic variants of TPMT and DPYD genes associated with the response to drug therapy in cancer practice among 9 ethnic groups of the Russian Federation
Published in Terapevtic̆eskii arhiv (03-09-2020)“…To study the peculiarities of carrying clinically significant allelic variants of TPMT and DPYD genes associated with the response to drug therapy in cancer…”
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Antihypertensive Effect Of Amlodipine In Co-Administration With Omeprazole In Patients With Hypertension And Acid-Related Disorders: Cytochrome P450-Associated Aspects
Published in Pharmacogenomics and personalized medicine (01-01-2019)“…CYP2C19 and CYP3A are the main enzymes involved in omeprazole metabolism, while CYP3A is the principal enzyme family for amlodipine biotransformation…”
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CYP3A and CYP2C19 activity in urine in relation to CYP3A4, CYP3A5, and CYP2C19 polymorphisms in Russian peptic ulcer patients taking omeprazole
Published in Pharmacogenomics and personalized medicine (01-01-2018)“…Proton pump inhibitors (PPIs) are metabolized by cytochrome P450. CYP2C19 is the main isoenzyme for the majority of PPI, whereas CYP3A family is a secondary…”
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Comparison of CYP2C9 , CYP2C19 , CYP2D6 , ABCB1 , and SLCO1B1 gene-polymorphism frequency in Russian and Nanai populations
Published in Pharmacogenomics and personalized medicine (01-01-2017)“…The efficiency and safety of drug therapy depends on the peculiarities of functioning of the P450 cytochrome group and transporting proteins. There are…”
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Urine metabolic ratio of omeprazole in relation to CYP2C19 polymorphisms in Russian peptic ulcer patients
Published in Pharmacogenomics and personalized medicine (01-01-2017)“…CYP2C19 is known to be the main enzyme of biotransformation of proton pump inhibitors (PPIs), whereas the gene is highly polymorphic. Genotyping and…”
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Do CYP2C19 and ABCB1 gene polymorphisms and low CYP3A4 isoenzyme activity have an impact on stent implantation complications in acute coronary syndrome patients?
Published in Pharmacogenomics and personalized medicine (01-01-2017)“…The aim of this study was to determine the impact of and gene polymorphisms and CYP3A4 isoenzyme activity on stent implantation complications among patients…”
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