Search Results - "Sowers, Mark L."

Glioblastoma and Methionine Addiction by Sowers, Mark L, Sowers, Lawrence C

“…Glioblastoma is a fatal brain tumor with a bleak prognosis. The use of chemotherapy, primarily the alkylating agent temozolomide, coupled with radiation and…”
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Chemical and enzymatic modifications of 5-methylcytosine at the intersection of DNA damage, repair, and epigenetic reprogramming by Baljinnyam, Tuvshintugs, Sowers, Mark L, Hsu, Chia Wei, Conrad, James W, Herring, Jason L, Hackfeld, Linda C, Sowers, Lawrence C

“…The DNA of all living organisms is persistently damaged by endogenous reactions including deamination and oxidation. Such damage, if not repaired correctly,…”
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A combinatorial system to examine the enzymatic repair of multiply damaged DNA substrates by Hsu, Chia Wei, Conrad, James W, Sowers, Mark L, Baljinnyam, Tuvshintugs, Herring, Jason L, Hackfeld, Linda C, Hatch, Sandra S, Sowers, Lawrence C

“…DNA damage drives genetic mutations that underlie the development of cancer in humans. Multiple pathways have been described in mammalian cells which can…”
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DNA Base Excision Repair Intermediates Influence Duplex-Quadruplex Equilibrium by Sowers, Mark L, Conrad, James W, Chang-Gu, Bruce, Cherryhomes, Ellie, Hackfeld, Linda C, Sowers, Lawrence C

“…Although genomic DNA is predominantly duplex under physiological conditions, particular sequence motifs can favor the formation of alternative secondary…”
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Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis by Zhang, Kangling, Sowers, Mark L, Cherryhomes, Ellie I, Singh, Vipul K, Mishra, Abhishek, Restrepo, Blanca I, Khan, Arshad, Jagannath, Chinnaswamy

“…Macrophages are the preeminent phagocytic cells which control multiple infections. Tuberculosis a leading cause of death in mankind and the causative organism…”
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Traumatic brain injury induces region-specific glutamate metabolism changes as measured by multiple mass spectrometry methods by Sowers, James L., Sowers, Mark L., Shavkunov, Alexander S., Hawkins, Bridget E., Wu, Ping, DeWitt, Douglas S., Prough, Donald S., Zhang, Kangling

“…The release of excess glutamate following traumatic brain injury (TBI) results in glutamate excitotoxicity and metabolic energy failure. Endogenous mechanisms…”
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Transition Mutations in the hTERT Promoter Are Unrelated to Potential i-motif Formation in the C-Rich Strand by Conrad, James W, Sowers, Mark L, Yap, Dianne Y, Cherryhomes, Ellie, Pettitt, B Montgomery, Khanipov, Kamil, Sowers, Lawrence C

“…Increased expression of the human telomere reverse transcriptase (hTERT) in tumors promotes tumor cell survival and diminishes the survival of patients…”
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Sex-Specific Proteomic Changes Induced by Genetic Deletion of Fibroblast Growth Factor 14 (FGF14), a Regulator of Neuronal Ion Channels by Sowers, Mark L, Re, Jessica Di, Wadsworth, Paul A, Shavkunov, Alexander S, Lichti, Cheryl, Zhang, Kangling, Laezza, Fernanda

“…Fibroblast growth factor 14 (FGF14) is a member of the intracellular FGFs, which is a group of proteins involved in neuronal ion channel regulation and…”
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Multi-OMICs analysis reveals metabolic and epigenetic changes associated with macrophage polarization by Sowers, Mark L., Tang, Hui, Singh, Vipul K., Khan, Arshad, Mishra, Abhishek, Restrepo, Blanca I., Jagannath, Chinnaswamy, Zhang, Kangling

“…Macrophages (MФ) are an essential immune cell for defense and repair that travel to different tissues and adapt based on local stimuli. A critical factor that…”
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Analysis of glucose-derived amino acids involved in one-carbon and cancer metabolism by stable-isotope tracing gas chromatography mass spectrometry by Sowers, Mark L., Herring, Jason, Zhang, William, Tang, Hui, Ou, Yang, Gu, Wei, Zhang, Kangling

“…A major hallmark of cancer is a perturbed metabolism resulting in high demand for various metabolites, glucose being the most well studied. While glucose can…”
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Bisphenol A Activates an Innate Viral Immune Response Pathway by Sowers, Mark L, Tang, Hui, Tian, Bing, Goldblum, Randall, Midoro-Horiuti, Terumi, Zhang, Kangling

“…Bisphenol A (BPA) is a ubiquitous component in the manufacturing of plastic. It is commonly found in food and beverage containers. Because of its broad…”
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Measurement of deaminated cytosine adducts in DNA using a novel hybrid thymine DNA glycosylase by Hsu, Chia Wei, Sowers, Mark L., Baljinnyam, Tuvshintugs, Herring, Jason L., Hackfeld, Linda C., Tang, Hui, Zhang, Kangling, Sowers, Lawrence C.

“…The hydrolytic deamination of cytosine and 5-methylcytosine drives many of the transition mutations observed in human cancer. The deamination-induced mutagenic…”
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Chemical and enzymatic modifications of 5-methylcytosine at the intersection of DNA damage, repair, and epigenetic reprogramming by Tuvshintugs Baljinnyam, Mark L. Sowers, Chia Wei Hsu, James W. Conrad, Jason L. Herring, Linda C. Hackfeld, Lawrence C. Sowers

“…The DNA of all living organisms is persistently damaged by endogenous reactions including deamination and oxidation. Such damage, if not repaired correctly,…”
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Characterization of a Novel Thermostable DNA Lyase Used To Prepare DNA for Next-Generation Sequencing by Baljinnyam, Tuvshintugs, Conrad, James W., Sowers, Mark L., Chang-Gu, Bruce, Herring, Jason L., Hackfeld, Linda C., Zhang, Kangling, Sowers, Lawrence C.

“…Recently, we constructed a hybrid thymine DNA glycosylase (hyTDG) by linking a 29-amino acid sequence from the human thymine DNA glycosylase with the catalytic…”
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Networked Communication between Polymerase and Exonuclease Active Sites in Human Mitochondrial DNA Polymerase by Sowers, Mark L, Anderson, Andrew P. P, Wrabl, James O, Yin, Y. Whitney

“…High fidelity human mitochondrial DNA polymerase (Pol γ) contains two active sites, a DNA polymerization site (pol) and a 3′-5′ exonuclease site (exo) for…”
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Measurement of Postreplicative DNA Metabolism and Damage in the Rodent Brain by Patel, Jay P, Sowers, Mark L, Herring, Jason L, Theruvathu, Jacob A, Emmett, Mark R, Hawkins, Bridget E, Zhang, Kangling, DeWitt, Douglas S, Prough, Donald S, Sowers, Lawrence C

“…The DNA of all organisms is metabolically active due to persistent endogenous DNA damage, repair, and enzyme-mediated base modification pathways important for…”
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DDDR-31. THE CHEMOTHERAPEUTIC ACTIVITY OF TEMOZOLOMIDE IS ANTAGONIZED BY ITS HYDROLYSIS PRODUCT, AIC by Sowers, Mark L, Baljinnyam, Tuvshintugs, Tang, Hui, Herring, Jason L, Hatch, Sandra, Valdes, Pablo, Zhang, Kangling, Sowers, Lawrence C

“…Temozolomide is the only FDA-approved drug that has demonstrated improved overall survival in patients with Glioblastoma. Despite the clinical impact it has…”
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TMET-35. UPREGULATION OF THE URIDINE SALVAGE PATHWAY IN MESENCHYMAL GLIOBLASTOMA STEM-LIKE CELLS by Baljinnyam, Tuvshintugs, Sowers, Mark L, Chang-Gu, Bruce, Tang, Hui, Herring, Jason L, Zhang, Kangling, Sowers, Lawrence C

“…Glioblastoma is a heterogenous tumor comprised of multiple molecular subtypes of cancer cells and cancer stem-like cells. Of particular importance are the…”
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Analysis of glucose-derived amino acids involved in one-carbon and cancer metabolism by stable-isotope labeling and gas chromatography mass spectrometry by Sowers, Mark L., Herring, Jason, Zhang, William, Tang, Hui, Ou, Yang, Gu, Wei, Zhang, Kangling

“…A major hallmark of cancer is a perturbed metabolism resulting in high demand for various metabolites, glucose being the most well studied. While glucose can…”
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Simple Experiments in Atmospheric Physics: Crepuscular Ray by Bohren, Craig, Sowers, Mark L.

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