Search Results - "Sowden, Mark P."

Extracellular and Intracellular Cyclophilin A, Native and Post-Translationally Modified, Show Diverse and Specific Pathological Roles in Diseases by Xue, Chao, Sowden, Mark P, Berk, Bradford C

“…CypA (cyclophilin A) is a ubiquitous and highly conserved protein with peptidyl prolyl isomerase activity. Because of its highly abundant level in the…”
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Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase by Sparks, Janet D, Collins, Heidi L, Chirieac, Doru V, Cianci, Joanne, Jokinen, Jenny, Sowden, Mark P, Galloway, Chad A, Sparks, Charles E

“…We have previously reported a positive correlation between the expression of BHMT (betaine-homocysteine S-methyltransferase) and ApoB (apolipoprotein B) in rat…”
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structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1 by Xie, K, Sowden, M.P, Dance, G.S.C, Torelli, A.T, Smith, H.C, Wedekind, J.E

“…Activation-induced deaminase (AID) uses base deamination for class-switch recombination and somatic hypermutation and is related to the mammalian RNA-editing…”
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Structural Phylogenetic Analysis of Activation-Induced Deaminase Function by Ichikawa, H. Travis, Sowden, Mark P, Torelli, Andrew T, Bachl, Jurgen, Huang, Pinwei, Dance, Geoffrey S. C, Marr, Shauna H, Robert, Jacques, Wedekind, Joseph E, Smith, Harold C, Bottaro, Andrea

“…In mammals, activation-induced deaminase (AID) initiates somatic hypermutation (SHM) and class switch recombination (CSR) of Ig genes. SHM and CSR activities…”
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Increasing the yield of soluble recombinant protein expressed in E. coli by induction during late log phase by Galloway, Chad A, Sowden, Mark P, Smith, Harold C

“…Recombinant mammalian proteins expressed in E. coli can be difficult to purify in high yield in a soluble and functional form. Various techniques have been…”
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Strain‐selective efficacy of sacubitril/valsartan on carotid fibrosis in response to injury in two inbred mouse strains by Korshunov, Vyacheslav A., Quinn, Breandan, Faiyaz, Abrar, Ahmed, Rifat, Sowden, Mark P., Doyley, Marvin M., Berk, Bradford C.

“…Background and Purpose Sacubitril/valsartan (Sac/val) is more effective than valsartan in lowering BP and mortality in patients with heart failure. Here, we…”
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The editosome for cytidine to uridine mRNA editing has a native complexity of 27S: identification of intracellular domains containing active and inactive editing factors by Sowden, Mark P, Ballatori, Nazzareno, Jensen, Karen L de Mesy, Reed, Lakesha Hamilton, Smith, Harold C

“…Apolipoprotein B mRNA cytidine to uridine editing requires the assembly of a multiprotein editosome comprised minimally of the catalytic subunit,…”
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G-Protein–Coupled Receptor-2–Interacting Protein-1 Is Required for Endothelial Cell Directional Migration and Tumor Angiogenesis via Cortactin-Dependent Lamellipodia Formation by Majumder, Syamantak, Sowden, Mark P, Gerber, Scott A, Thomas, Tamlyn, Christie, Christine K, Mohan, Amy, Yin, Guoyong, Lord, Edith M, Berk, Bradford C, Pang, Jinjiang

“…OBJECTIVE—Recent evidence suggests G-protein–coupled receptor-2–interacting protein-1 (GIT1) overexpression in several human metastatic tumors, including…”
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Two Proteins Essential for Apolipoprotein B mRNA Editing Are Expressed from a Single Gene through Alternative Splicing by Dance, Geoffrey S.C., Sowden, Mark P., Cartegni, Luca, Cooper, Ellen, Krainer, Adrian R., Smith, Harold C.

“…Apolipoprotein B (apoB) mRNA editing involves site-specific deamination of cytidine to form uridine, resulting in the production of an in-frame stop codon…”
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Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells by Sparks, Robert P., Guida, Wayne C., Sowden, Mark P., Jenkins, Jermaine L., Starr, Matthew L., Fratti, Rutilio A., Sparks, Charles E., Sparks, Janet D.

“…Studies examining the relationship between cellular sortilin and VLDL-B100 secretion demonstrate inconsistent results. Current studies explore the possibility…”
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Identification of Novel Alternative Splice Variants of APOBEC-1 Complementation Factor with Different Capacities to Support Apolipoprotein B mRNA Editing by Sowden, Mark P., Lehmann, David M., Lin, Xiaoyan, Smith, Charles O., Smith, Harold C.

“…Two novel mRNA transcripts have been identified that result from species- and tissue-specific, alternative polyadenylation and splicing of the pre-mRNA…”
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Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business by Wedekind, Joseph E., Dance, Geoffrey S.C., Sowden, Mark.P., Smith, Harold C.

“…Alteration of mRNA sequence through base modification mRNA editing frequently generates protein diversity. Several proteins have been identified as being…”
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Metabolic regulation of ApoB mRNA editing is associated with phosphorylation of APOBEC-1 complementation factor by Lehmann, David M., Galloway, Chad A., Sowden, Mark P., Smith, Harold C.

“…Apolipoprotein B (apoB) mRNA editing is a nuclear event that minimally requires the RNA substrate, APOBEC-1 and APOBEC-1 Complementation Factor (ACF). The…”
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APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic by Bennett, Ryan P., Diner, Elie, Sowden, Mark P., Lees, Joshua A., Wedekind, Joseph E., Smith, Harold C.

“…Human APOBEC3G (hA3G) is a member of the APOBEC-1 related protein (ARP) family of cytidine deaminases. hA3G functions as a natural defense against endogenous…”
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Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line by Reeder, Jay E, Sowden, Mark P, Messing, Edward M, Klover, Peter, Villa-Moruzzi, Emma, Ludlow, John W

“…BACKGROUND: One of the major cellular serine/threonine protein phosphatases is protein phosphatase type 1 (PP1). Studies employing many eukaryotic systems all…”
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Functional characterization of APOBEC-1 complementation factor phosphorylation sites by Lehmann, David M., Galloway, Chad A., MacElrevey, Celeste, Sowden, Mark P., Wedekind, Joseph E., Smith, Harold C.

“…ApoB mRNA editing involves site-specific deamination of cytidine 6666 producing an in-frame translation stop codon. Editing minimally requires APOBEC-1 and…”
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Induction of Cytidine to Uridine Editing on Cytoplasmic Apolipoprotein B mRNA by Overexpressing APOBEC-1 by Yang, Yan, Sowden, Mark P., Smith, Harold C.

“…Post-transcriptional editing of apolipoprotein B (apoB) mRNA is regulated in hepatic cells to achieve a steady state proportion of edited and unedited RNA…”
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Activation induced deaminase: the importance of being specific by Smith, Harold C., Bottaro, Andrea, Sowden, Mark P., Wedekind, Joseph E.

“…Activation-induced deaminase (AID) is required for class switch recombination and somatic hypermutation in immunoglobulin genes. Although the preponderance of…”
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Base-modification mRNA editing through deamination — the good, the bad and the unregulated by Smith, Harold C., Sowden, Mark P.

“…RNA editing is a co- or post-transcriptional process in which select nucleotide sequences in RNA are altered from that originally encoded in the genome. The…”
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Lipoprotein alterations in 10- and 20-week-old Zucker diabetic fatty rats: Hyperinsulinemic versus insulinopenic hyperglycemia by Sparks, Janet D., Phung, Thuy L., Bolognino, Mary, Cianci, Joanne, Khurana, Rohit, Peterson, Richard G., Sowden, Mark P., Corsetti, James P., Sparks, Charles E.

“…Lipoprotein and apolipoprotein parameters were studied in the male Zucker diabetic fatty (ZDF) rat at 10 and 20 weeks of age, corresponding to hyperinsulinemic…”
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