Search Results - "Sovadinova, Iva"

Structural Determinants of Antimicrobial Activity and Biocompatibility in Membrane-Disrupting Methacrylamide Random Copolymers by Palermo, Edmund F, Sovadinova, Iva, Kuroda, Kenichi

“…Low molecular weight random copolymers bearing protonated primary amine groups and hydrophobic alkyl groups in the side chains were synthesized and their…”
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From fish to cells: Establishment of continuous cell lines from embryos of annual killifish Nothobranchius furzeri and N. kadleci by Součková, Kamila, Jasík, Matej, Sovadinová, Iva, Sember, Alexandr, Sychrová, Eliška, Konieczna, Anna, Bystrý, Vojtěch, Dyková, Iva, Blažek, Radim, Lukšíková, Karolína, Pavlica, Tomáš, Jankásek, Marek, Altmanová, Marie, Žák, Jakub, Zbončáková, Adriana, Reichard, Martin, Slabý, Ondřej

“…•Establishment of new embryonic cell lines from annual killifish N. furzeri and N. kadleci.•Cell lines were characterized by a wide range of approaches.•Lines…”
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Biomimetic antimicrobial polymers—Design, characterization, antimicrobial, and novel applications by Takahashi, Haruko, Sovadinova, Iva, Yasuhara, Kazuma, Vemparala, Satyavani, Caputo, Gregory A., Kuroda, Kenichi

“…Biomimetic antimicrobial polymers have been an area of great interest as the need for novel antimicrobial compounds grows due to the development of resistance…”
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Mechanism of Polymer-Induced Hemolysis: Nanosized Pore Formation and Osmotic Lysis by Sovadinova, Iva, Palermo, Edmund F, Huang, Rui, Thoma, Laura M, Kuroda, Kenichi

“…Hemolysis induced by antimicrobial polymers was examined to gain an understanding of the mechanism of polymer toxicity to human cells. A series of cationic…”
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New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens-a PARC project by Audebert, Marc, Assmann, Ann-Sophie, Azqueta, Amaya, Babica, Pavel, Benfenati, Emilio, Bortoli, Sylvie, Bouwman, Peter, Braeuning, Albert, Burgdorf, Tanja, Coumoul, Xavier, Debizet, Kloé, Dusinska, Maria, Ertych, Norman, Fahrer, Jörg, Fetz, Verena, Le Hégarat, Ludovic, López de Cerain, Adela, Heusinkveld, Harm J, Hogeveen, Kevin, Jacobs, Miriam N, Luijten, Mirjam, Raitano, Giuseppa, Recoules, Cynthia, Rundén-Pran, Elise, Saleh, Mariam, Sovadinová, Iva, Stampar, Martina, Thibol, Lea, Tomkiewicz, Céline, Vettorazzi, Ariane, Van de Water, Bob, El Yamani, Naouale, Zegura, Bojana, Oelgeschläger, Michael

“…Carcinogenic chemicals, or their metabolites, can be classified as genotoxic or non-genotoxic carcinogens (NGTxCs). Genotoxic compounds induce DNA damage,…”
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Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model by Sovadinova, Iva, Babica, Pavel, Böke, Hatice, Kumar, Esha, Wilke, Andrew, Park, Joon-Suk, Trosko, James E, Upham, Brad L

“…Dysregulation of gap junctional intercellular communication (GJIC) has been associated with different pathologies, including cancer; however, molecular…”
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Activity and Mechanism of Antimicrobial Peptide-Mimetic Amphiphilic Polymethacrylate Derivatives by Sovadinova, Iva, Palermo, Edmund F., Urban, Michael, Mpiga, Philomene, Caputo, Gregory A., Kuroda, Kenichi

“…Cationic amphiphilic polymethacrylate derivatives (PMAs) have shown potential as a novel class of synthetic antimicrobials. A panel of PMAs with varied ratios…”
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Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events by Tanabe, Shihori, O’Brien, Jason, Tollefsen, Knut Erik, Kim, Youngjun, Chauhan, Vinita, Yauk, Carole, Huliganga, Elizabeth, Rudel, Ruthann A., Kay, Jennifer E., Helm, Jessica S., Beaton, Danielle, Filipovska, Julija, Sovadinova, Iva, Garcia-Reyero, Natalia, Mally, Angela, Poulsen, Sarah Søs, Delrue, Nathalie, Fritsche, Ellen, Luettich, Karsta, La Rocca, Cinzia, Yepiskoposyan, Hasmik, Klose, Jördis, Danielsen, Pernille Høgh, Esterhuizen, Maranda, Jacobsen, Nicklas Raun, Vogel, Ulla, Gant, Timothy W., Choi, Ian, FitzGerald, Rex

“…Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are formed as a result of natural cellular processes, intracellular signaling, or as adverse…”
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Tumor promoting properties of a cigarette smoke prevalent polycyclic aromatic hydrocarbon as indicated by the inhibition of gap junctional intercellular communication via phosphatidylcholine‐specific phospholipase C by Upham, Brad L., Bláha, Ludek, Babica, Pavel, Park, Joon‐Suk, Sovadinova, Iva, Pudrith, Charles, Rummel, Alisa M., Weis, Liliane M., Sai, Kimie, Tithof, Patti K., Gužvić, Miodrag, Vondráček, Jan, Machala, Miroslav, Trosko, James E.

“…Inhibition of gap junctional intercellular communication (GJIC) and the activation of intracellular mitogenic pathways are common hallmarks of epithelial…”
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Cytotoxicity and aryl hydrocarbon receptor-mediated activity of N-heterocyclic polycyclic aromatic hydrocarbons: Structure-activity relationships by Sovadinová, Iva, Bláha, Luděk, Janošek, Jaroslav, Hilscherová, Klára, Giesy, John P., Jones, Paul D., Holoubek, Ivan

“…Toxic effects of many persistent organic pollutants (e.g., polychlorinated biphenyls or polychlorinated dibenzo‐p‐dioxins and furans) are mediated via the aryl…”
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Applicability of Scrape Loading-Dye Transfer Assay for Non-Genotoxic Carcinogen Testing by Sovadinová, Iva, Upham, Brad L., Trosko, James E., Babica, Pavel

“…Dysregulation of gap junction intercellular communication (GJIC) is recognized as one of the key hallmarks for identifying non-genotoxic carcinogens (NGTxC)…”
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Unexpected Enhancement of Antimicrobial Polymer Activity against Staphylococcus aureus in the Presence of Fetal Bovine Serum by Sovadinová, Iva, Kuroda, Kenichi, Palermo, Edmund F.

“…Cationic and amphiphilic polymers are known to exert broad-spectrum antibacterial activity by a putative mechanism of membrane disruption. Typically,…”
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Endocrine-disrupting chemicals affect Sertoli TM4 cell functionality through dysregulation of gap junctional intercellular communication in vitro by Yawer, Affiefa, Sychrová, Eliška, Raška, Jan, Babica, Pavel, Sovadinová, Iva

“…The frequencies of adverse outcomes associated with male reproductive health, including infertility and testicular cancer, are increasing. These adverse trends…”
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Improved multiparametric scrape loading-dye transfer assay for a simultaneous high-throughput analysis of gap junctional intercellular communication, cell density and viability by Dydowiczová, Aneta, Brózman, Ondřej, Babica, Pavel, Sovadinová, Iva

“…Gap junctional intercellular communication (GJIC) is a vital cellular process required for maintenance of tissue homeostasis. In vitro assessment of GJIC…”
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Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells by Čtveráčková, Lucie, Jančula, Daniel, Raška, Jan, Babica, Pavel, Sovadinová, Iva

“…Humans are exposed to phthalates released from plastics, cosmetics, or food on a daily basis. Phthalates have low acute liver toxicity, but their chronic…”
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Endocrine-disrupting chemicals rapidly affect intercellular signaling in Leydig cells by Yawer, Affiefa, Sychrová, Eliška, Labohá, Petra, Raška, Jan, Jambor, Tomáš, Babica, Pavel, Sovadinová, Iva

“…A decline in male fertility possibly caused by environmental contaminants, namely endocrine-disrupting chemicals (EDCs), is a topic of public concern and…”
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Hepatotoxicity of cyanotoxin microcystin-LR in human: Insights into mechanisms of action in the 3D culture model Hepoid-HepaRG by Chowdhury, Riju R., Rose, Sophie, Ezan, Frédéric, Sovadinová, Iva, Babica, Pavel, Langouët, Sophie

“…Microcystin-LR (MC-LR) is a potent hepatotoxin produced by harmful cyanobacterial blooms (CyanoHABs). MC-LR targets highly differentiated hepatocytes…”
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Scrape Loading/Dye Transfer Assay by Babica, Pavel, Sovadinová, Iva, Upham, Brad L

“…The scrape loading/dye transfer (SL/DT) technique is a simple functional assay for the simultaneous assessment of gap junctional intercellular communication…”
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Cyanotoxin cylindrospermopsin disrupts lipid homeostasis and metabolism in a 3D in vitro model of the human liver by Chowdhury, Riju Roy, Grosso, Marina Felipe, Gadara, Darshak Chandulal, Spáčil, Zdeněk, Vidová, Veronika, Sovadinová, Iva, Babica, Pavel

“…Cylindrospermopsin, a potent hepatotoxin produced by harmful cyanobacterial blooms, poses environmental and human health concerns. We used a 3D human liver in…”
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Polycyclic Aromatic Hydrocarbons and Endocrine Disruption: Role of Testicular Gap Junctional Intercellular Communication and Connexins by Kubincová, Petra, Sychrová, Eliška, Raška, Jan, Basu, Amrita, Yawer, Affiefa, Dydowiczová, Aneta, Babica, Pavel, Sovadinová, Iva

“…Abstract Ambient air pollution and smoking are well-documented risk factors for male infertility. Prevalent air pollutants and cigarette smoke components,…”
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