Vitamin D and PTH: data from a cross-sectional study in an equatorial population

Objective: Investigate the prevalence of vitamin D deficiency in an equatorial population through a large-sample study. Methods: Cross-sectional study with 30,224 healthy individuals from the North Region, in Brazil (Amazônia – state of Pará), who had 25-hydroxy-vitamin D (25(OH)D) and intact parath...

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Published in:	Endocrine Connections Vol. 9; no. 7; pp. 667 - 675
Main Authors:	Neves Marques de Queiroz, Natércia, Trindade Cunha de Melo, Franciane, de Souza Resende, Fabrício, Corrêa Janaú, Luísa, Jorge Kzan de Souza Neto, Norberto, Nascimento de Lemos, Manuela, Lobato Virgolino, Ana Carolina, Neres Iunes de Oliveira, Maria Clara, Leite de Alcântara, Angélica, Vilhena de Moraes, Lorena, Franco David, Tiago, Maia da Silva, Wanderson, Souza Reis, Scarlatt, Costa dos Santos, Márcia, Contente Braga de Souza, Ana Carolina, Freire Piani, Pedro Paulo, Arroyo Lara Mourão, Neyla, Mileo Felício, Karem, Felício Abrahão Neto, João, Felício, João Soares
Format:	Journal Article
Language:	English
Published:	England Bioscientifica Ltd 01-07-2020 Bioscientifica
Subjects:	endocrinology epidemiology hypovitaminosis d vitamin d epidemiology hypovitaminosis D vitamin D endocrinology
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Summary:	Objective: Investigate the prevalence of vitamin D deficiency in an equatorial population through a large-sample study. Methods: Cross-sectional study with 30,224 healthy individuals from the North Region, in Brazil (Amazônia – state of Pará), who had 25-hydroxy-vitamin D (25(OH)D) and intact parathyroid hormone (PTH) serum levels measured by immunoassay method. Those with history of acute or chronic diseases were excluded. Abnormal levels of calcium, creatinine, glycemia and albumin were also exclusion criteria. Results: 25(OH)D levels were 29.1 ± 8.2 ng/mL and values <12.7 ng/mL were equal to < −2 s.d. below average. Hypovitaminosis D was present in 10% of subjects according to the Institute of Medicine (values <20 ng/mL) and in 59%, in consonance with Endocrine Society (values 20–30 ng/mL as insufficiency and <20 ng/mL as deficiency) criteria. Individuals were divided according to four age brackets: children, adolescents, adults and elderly, and their 25(OH)D levels were: 33 ± 9; 28.5 ± 7.4; 28.3 ± 7.7; 29.3 ± 8.5 ng/mL, respectively. All groups differed in 25(OH)D, except adolescents vs adults. Regression model showed BMI, sex, living zone (urban or rural) and age as independent variables to 25(OH)D levels. Comparing subjects with vitamin D deficiency (<20 ng/mL) to those with vitamin D insufficiency (20–30 ng/mL), a difference between PTH levels in these two groups was observed (95.9 ± 24.7 pg/mL vs 44.2 ± 64.5 pg/mL; P < 0.01). Additionally, the most accurate predictive vitamin D level for subclinical hyperparathyroidism in ROC curve was 26 ng/mL. Conclusion: Our equatorial population showed low prevalence of vitamin D hypovitaminosis ranging with age bracket. The insufficient category by Endocrine Society was corroborated by our PTH data.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2049-3614 2049-3614
DOI:	10.1530/EC-20-0206