Search Results - "Souza Macchi, Fernanda"

Synthesis and Antimycobacterial Activity of 3-Phenyl-1H-indoles by Jardim Etchart, Renata, Rambo, Raoní S., Lopes Abbadi, Bruno, Sperotto, Nathalia, Ev Neves, Christiano, Fries Silva, Fernanda, Dornelles, Maiele, Duarte, Lovaine, Souza Macchi, Fernanda, Alberton Perelló, Marcia, Vescia Lourega, Rogério, Valim Bizarro, Cristiano, Basso, Luiz Augusto, Machado, Pablo

“…Tuberculosis has been described as a global health crisis since the 1990s, with an estimated 1.4 million deaths in the last year. Herein, a series of 20…”
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Design of Novel Inhibitors of Human Thymidine Phosphorylase: Synthesis, Enzyme Inhibition, in Vitro Toxicity, and Impact on Human Glioblastoma Cancer by de Moura Sperotto, Nathalia D, Deves Roth, Candida, Rodrigues-Junior, Valnês S, Ev Neves, Christiano, Reisdorfer Paula, Fávero, da Silva Dadda, Adilio, Bergo, Pedro, Freitas de Freitas, Talita, Souza Macchi, Fernanda, Moura, Sidnei, Duarte de Souza, Ana Paula, Campos, Maria Martha, Valim Bizarro, Cristiano, Santos, Diógenes Santiago, Basso, Luiz Augusto, Machado, Pablo

“…Overexpressed human thymidine phosphorylase (hTP) has been associated with cancer aggressiveness and poor prognosis by triggering proangiogenic and…”
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Synthesis and mechanistic investigation of iron(II) complexes of isoniazid and derivatives as a redox-mediated activation strategy for anti-tuberculosis therapy by Laborde, Julie, Deraeve, Céline, de Mesquita Vieira, Francisca Gilmara, Sournia-Saquet, Alix, Rechignat, Lionel, Villela, Anne Drumond, Abbadi, Bruno Lopes, Macchi, Fernanda Souza, Pissinate, Kenia, Bizarro, Cristiano V., Machado, Pablo, Basso, Luiz Augusto, Pratviel, Geneviève, de França Lopes, Luiz Gonzaga, Sousa, Eduardo Henrique Silva, Bernardes-Génisson, Vania

“…The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (MTB) represents a major threat to global health. Isoniazid (INH) is a prodrug used…”
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8-Mercaptoguanine-based inhibitors of Mycobacterium tuberculosis dihydroneopterin aldolase: synthesis, in vitro inhibition and docking studies by Czeczot, Alexia de Matos, Roth, Candida Deves, Ducati, Rodrigo Gay, Pissinate, Kenia, Rambo, Raoní Scheibler, Timmers, Luís Fernando Saraiva Macedo, Abbadi, Bruno Lopes, Macchi, Fernanda Souza, Pestana, Víctor Zajaczkowski, Basso, Luiz Augusto, Machado, Pablo, Bizarro, Cristiano Valim

“…The dihydroneopterin aldolase (DHNA, EC 4.1.2.25) activity of FolB protein is required for the conversion of 7,8-dihydroneopterin (DHNP) to…”
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Exploring Scaffold Hopping for Novel 2‑(Quinolin-4-yloxy)acetamides with Enhanced Antimycobacterial Activity by Borsoi, Ana Flávia, Silva Ramos, Alessandro, Sperotto, Nathalia, Abbadi, Bruno Lopes, Souza Macchi Hopf, Fernanda, da Silva Dadda, Adilio, Scheibler Rambo, Raoní, Neves Muniz, Mauro, Delgado Paz, Josiane, Silveira Grams, Estevão, Fries da Silva, Fernanda, Pissinate, Kenia, Galina, Luiza, Calle González, Laura, Silva Duarte, Lovaine, Alberton Perelló, Marcia, de Matos Czeczot, Alexia, Bizarro, Cristiano Valim, Basso, Luiz Augusto, Machado, Pablo

“…Utilizing a scaffold-hopping strategy from the drug candidate telacebec, a novel series of 2-(quinolin-4-yloxy)­acetamides was synthesized and evaluated as…”
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Antitubercular Activity of Novel 2‑(Quinoline-4-yloxy)acetamides with Improved Drug-Like Properties by Borsoi, Ana Flávia, Alice, Laura Manzoli, Sperotto, Nathalia, Ramos, Alessandro Silva, Abbadi, Bruno Lopes, Macchi Hopf, Fernanda Souza, Silva Dadda, Adilio da, Rambo, Raoní S., Madeira Silva, Rodrigo Braccini, Paz, Josiane Delgado, Pissinate, Kenia, Muniz, Mauro Neves, Neves, Christiano Ev, Galina, Luiza, González, Laura Calle, Perelló, Marcia Alberton, de Matos Czeczot, Alexia, Leyser, Mariana, de Oliveira, Sílvia Dias, de Araújo Lock, Graziela, de Araújo, Bibiana Verlindo, Costa, Teresa Dalla, Bizarro, Cristiano Valim, Basso, Luiz Augusto, Machado, Pablo

“…Using cycloalkyl and electron-donating groups to decrease the carbonyl electrophilicity, a novel series of 2-(quinoline-4-yloxy)­acetamides was synthesized and…”
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Effect of LPS on the Viability and Proliferation of Human Oral and Esophageal Cancer Cell Lines by Gonçalves, Márcia, Cappellari, Ángelica Regina, Santos Junior, André Avelino dos, Marchi, Fernanda Olicheski de, Macchi, Fernanda Souza, Antunes, Krist Helen, Souza, Ana Paula Duarte de, Morrone, Fernanda Bueno

“…The esophagus and mouth tumors are very frequent malignancies worldwide. Lipopolysaccharides (LPS) are capable of regulating gene expression of…”
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Design, synthesis, and evaluation of new 2-(quinoline-4-yloxy)acetamide-based antituberculosis agents by Borsoi, Ana Flávia, Paz, Josiane Delgado, Abbadi, Bruno Lopes, Macchi, Fernanda Souza, Sperotto, Nathalia, Pissinate, Kenia, Rambo, Raoní S., Ramos, Alessandro Silva, Machado, Diana, Viveiros, Miguel, Bizarro, Cristiano Valim, Basso, Luiz Augusto, Machado, Pablo

“…Using a classical molecular simplification approach, a series of 36 quinolines were synthesized and evaluated as in vitro inhibitors of Mycobacterium…”
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Identification of potential inhibitors of Mycobacterium tuberculosis shikimate kinase: molecular docking, in silico toxicity and in vitro experiments by Freitas de Freitas, Talita, Roth, Candida Deves, Abbadi, Bruno Lopes, Hopf, Fernanda Souza Macchi, Perelló, Marcia Alberton, de Matos Czeczot, Alexia, de Souza, Eduardo Vieira, Borsoi, Ana Flávia, Machado, Pablo, Bizarro, Cristiano Valim, Basso, Luiz Augusto, Timmers, Luis Fernando Saraiva Macedo

“…Tuberculosis (TB) is one of the main causes of death from a single pathological agent, Mycobacterium tuberculosis ( Mtb ). In addition, the emergence of…”
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1H-Benzo[d]imidazoles and 3,4-dihydroquinazolin-4-ones: Design, synthesis and antitubercular activity by Macchi, Fernanda Souza, Pissinate, Kenia, Villela, Anne Drumond, Abbadi, Bruno Lopes, Rodrigues-Junior, Valnês, Nabinger, Débora Dreher, Altenhofen, Stefani, Sperotto, Nathalia, da Silva Dadda, Adílio, Subtil, Fernanda Teixeira, de Freitas, Talita Freitas, Erhart Rauber, Ana Paula, Borsoi, Ana Flávia, Bonan, Carla Denise, Bizarro, Cristiano Valim, Basso, Luiz Augusto, Santos, Diógenes Santiago, Machado, Pablo

“…Using a classical hybridization approach, a series of 1H-benzo[d]imidazoles and 3,4-dihydroquinazolin-4-ones were synthesized (39 examples) and evaluated as…”
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Ultrasound-assisted synthesis of 2-amino-1,3,4-oxadiazoles through NBS-mediated oxidative cyclization of semicarbazones by Borsoi, Ana Flávia, Coldeira, Mateus Emanuel, Pissinate, Kenia, Macchi, Fernanda Souza, Basso, Luiz Augusto, Santos, Diógenes Santiago, Machado, Pablo

“…A ultrasound-assisted oxidative cyclization of semicarbazones using N-bromosuccinimide in the presence of sodium acetate was established providing efficient…”
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Pentacyanoferrate(II) complex of pyridine-4- and pyrazine-2-hydroxamic acid as source of HNO: investigation of anti-tubercular and vasodilation activities by Carvalho, Edinilton Muniz, de Freitas Paulo, Tercio, Saquet, Alix Sournia, Abbadi, Bruno Lopes, Macchi, Fernanda Souza, Bizarro, Cristiano Valim, de Morais Campos, Rafael, Ferreira, Talles Luann Abrantes, do Nascimento, Nilberto Robson Falcão, Lopes, Luiz Gonzaga França, Chauvin, Remi, Sousa, Eduardo Henrique Silva, Bernardes-Génisson, Vania

“…A pharmacophore design approach, based on the coordination chemistry of an intimate molecular hybrid of active metabolites of pro-drugs, known to release…”
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Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation by Paz, Josiane Delgado, Denise de Moura Sperotto, Nathalia, Ramos, Alessandro Silva, Pissinate, Kenia, da Silva Rodrigues Junior, Valnês, Abbadi, Bruno Lopes, Borsoi, Ana Flávia, Rambo, Raoní Scheibler, Corso Minotto, Ana Carolina, da Silva Dadda, Adilio, Galina, Luiza, Macchi Hopf, Fernanda Souza, Muniz, Mauro Neves, Borges Martinelli, Leonardo Kras, Roth, Candida Deves, Madeira Silva, Rodrigo Braccini, Perelló, Marcia Alberton, de Matos Czeczot, Alexia, Neves, Christiano Ev, Duarte, Lovaine Silva, Leyser, Mariana, Dias de Oliveira, Sílvia, Bizarro, Cristiano Valim, Machado, Pablo, Basso, Luiz Augusto

“…Herein a series of 4-aminoquinolines were synthesized in an attempt to optimize and study the structural features related to LABIO-17 biological activity, a…”
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