Search Results - "Souza Anselmo, Carina"
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Zebrafish (Danio rerio): A valuable tool for predicting the metabolism of xenobiotics in humans?
Published in Comparative biochemistry and physiology. Toxicology & pharmacology (01-10-2018)“…Zebrafish has become a popular model organism in several lines of biological research sharing physiological, morphological and histological similarities with…”
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Is zebrafish (Danio rerio) a tool for human‐like metabolism study?
Published in Drug testing and analysis (01-11-2017)“…One of the greatest challenges in anti‐doping science is the large number of substances available and the difficulty in finding the best analytical targets to…”
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Metabolism of synthetic cathinones through the zebrafish water tank model: a promising tool for forensic toxicology laboratories
Published in Forensic toxicology (2021)“…Purpose The aim of this study was to identify in vivo phase I metabolites of five psychoactive substances: N -ethylpentylone, ethylone, methylone, α-PVP and…”
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Chiral Analysis of Amphetamine and Methamphetamine in Urine by Liquid Chromatography-Tandem Mass Spectrometry Applying Mosher Derivatization
Published in Chromatographia (2021)“…Methamphetamine (MA) and amphetamine (AM) are central nervous system doping agents, listed in the WADA Prohibited List, which in the past years showed the…”
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Development of a liquid chromatography Q Exactive high resolution mass spectrometry method by the Box-Behnken design for the investigation of sibutramine urinary metabolites
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01-09-2019)“…Sibutramine is cited by the World Anti-Doping Agency as a stimulant. According to the literature, sibutramine is extensively metabolized into…”
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Development of a high performance liquid chromatography method for quantification of isomers β-caryophyllene and α-humulene in copaiba oleoresin using the Box-Behnken design
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01-12-2013)“…•A chromatographic method with UV detection was developed to assay β-caryophyllene and α-humulene in copaiba oleoresin.•The RP-HPLC method was adequate to…”
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Pharmacokinetic study of xylazine in a zebrafish water tank, a human-like surrogate, by liquid chromatography Q-Orbitrap mass spectrometry
Published in Forensic toxicology (2020)“…Purpose This study aims to investigate a zebrafish ( Danio Rerio) water tank (ZWT) as an alternative model for the study of the metabolism of xylazine. Methods…”
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Zebrafish (Danio rerio) water tank model for the investigation of drug metabolism: Progress, outlook, and challenges
Published in Drug testing and analysis (01-11-2018)“…Zebrafish (Danio rerio) water tank (ZWT) approach was investigated as an alternative model for metabolism studies based on six different experiments with four…”
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Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain
Published in ACS chemical neuroscience (03-04-2024)“…Ketamine is a common anesthetic used in human and veterinary medicine. This drug has recently received increased medical and scientific attention due to its…”
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Phase II stanozolol metabolism study using the zebrafish water tank (ZWT) model
Published in Journal of pharmaceutical and biomedical analysis (20-02-2021)“…•The water tank in which the fish excreted the metabolites was analysed by LC-HRMS/MS and detailed fragmentation pattern is provided.•ZWT produced at least ten…”
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Identification and Characterization of Rotigotine Degradation Products by HPLC Coupled DAD and CAD Detectors and HRMS Through Q-Orbitrap and Electrospray Ionization
Published in Journal of pharmaceutical sciences (01-08-2024)“…Rotigotine (RTG) is a dopamine agonist used in the treatment of Parkinson's disease. As it is susceptible to oxidation, stability studies must be carefully…”
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Is zebrafish (Danio rerio) water tank model applicable for the assessment of glucocorticoids metabolism? The budesonide assessment
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01-08-2021)“…•Zebrafish as an alternative for the metabolism study of prohibited substances in doping control.•Evaluation of budesonide (BUD) metabolism profile in…”
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Development and validation of a dissolution test for lutein tablets and evaluation of intestinal permeability
Published in Food chemistry (01-11-2016)“…•Lutein presents instability in sodium lauryl sulfate aqueous medium.•Dissolution tests are an essential quality control tool for formulations containing…”
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