Search Results - "Souza, Tatiana de Arruda Campos Brasil"

Kinase inhibitor profile for human nek1, nek6, and nek7 and analysis of the structural basis for inhibitor specificity by Moraes, Eduardo Cruz, Meirelles, Gabriela Vaz, Honorato, Rodrigo Vargas, de Souza, Tatiana de Arruda Campos Brasil, de Souza, Edmarcia Elisa, Murakami, Mario Tyago, de Oliveira, Paulo Sergio Lopes, Kobarg, Jörg

“…Human Neks are a conserved protein kinase family related to cell cycle progression and cell division and are considered potential drug targets for the…”
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A Redox 2-Cys Mechanism Regulates the Catalytic Activity of Divergent Cyclophilins by Campos, Bruna Medéia, Sforça, Mauricio Luis, Ambrosio, Andre Luis Berteli, Domingues, Mariane Noronha, de Arruda Campos Brasil de Souza, Tatiana, Barbosa, João Alexandre Ribeiro Gonçalvez, Leme, Adriana Franco Paes, Perez, Carlos Alberto, Whittaker, Sara Britt-Marie, Murakami, Mario Tyago, de Matos Zeri, Ana Carolina, Benedetti, Celso Eduardo

“…The citrus (Citrus sinensis) cyclophilin CsCyp is a target of the Xanthomonas citri transcription activator-like effector PthA, required to elicit cankers on…”
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Protein kinases on carbon metabolism: potential targets for alternative chemotherapies against toxoplasmosis by Dos Santos, Denis Amilton, Souza, Higo Fernando Santos, Silber, Ariel M, de Souza, Tatiana de Arruda Campos Brasil, Ávila, Andréa Rodrigues

“…The apicomplexan parasite is the causative agent of toxoplasmosis, a global disease that significantly impacts human health. The clinical manifestations are…”
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Circumventing the side effects of L-asparaginase by Fonseca, Marcela Helena Gambim, Fiúza, Tayná da Silva, Morais, Stephanie Bath de, Souza, Tatiana de Arruda Campos Brasil de, Trevizani, Raphael

“…L-asparaginase is an enzyme that catalyzes the degradation of asparagine and successfully used in the treatment of acute lymphoblastic leukemia. L-asparaginase…”
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Human L‑asparaginase: Acquiring knowledge of its activation (Review) by de Morais, Stephanie Bath, de Souza, Tatiana de Arruda Campos Brasil

“…L-asparaginase enzymes have been a vital component of acute lymphoblastic leukemia therapy for >40 years. L-asparaginase acts by depleting plasma L-asparagine,…”
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Dissecting dual specificity: Identifying key residues in L-asparaginase for enhanced acute lymphoid leukemia therapy and reduced adverse effects by de Lima, Jhenifer Yonara, de Castro Andreassa, Emanuella, Venturi Biembengut, Ísis, de Arruda Campos Brasil de Souza, Tatiana

“…L-asparaginase from Escherichia coli (EcA) has been used for the treatment of acute lymphoid leukemia (ALL) since the 1970s. Nevertheless, the enzyme has a…”
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PatternLab V Handles Multiplex Spectra in Shotgun Proteomic Searches and Increases Identification by Clasen, Milan A., Santos, Marlon D. M., Kurt, Louise Ulrich, Fischer, Juliana, Camillo-Andrade, Amanda C., Sales, Lucas Albuquerque, de Arruda Campos Brasil de Souza, Tatiana, Lima, Diogo Borges, Gozzo, Fabio C., Valente, Richard Hemmi, Duran, Rosario, Barbosa, Valmir C., Carvalho, Paulo C.

“…Complex protein mixtures typically generate many tandem mass spectra produced by different peptides coisolated in the gas phase. Widely adopted proteomic data…”
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Coagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID-19 treatment: an in silico approach by Biembengut, Ísis Venturi, de Souza, Tatiana de Arruda Campos Brasil

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection depends on viral polyprotein processing, catalysed by the main proteinase (Mpro). The…”
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Targeting HDACs of apicomplexans: structural insights for a better treatment by de Siqueira, Caroline de Moraes, Fragoso, Mariana Sayuri Ishikawa, Severo, Vanessa Rossini, Biembengut, Isis Venturi, Nardelli, Sheila Cristina, de Souza, Tatiana de Arruda Campos Brasil

“…Aetiologic agents of diseases such as malaria and toxoplasmosis are found in representatives of the phylum Apicomplexa. Therefore, apicomplexan parasites are…”
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Biophysical Characterization of Alanine Aminotransferase from Trypanosoma cruzi by de Morais, Stephanie B, de Arruda Campos Brasil de Souza, Tatiana, Weiler, Ana V P, Murakami, Mario T

“…Aminotransferases are an important group of enzymes that catalyze the transfer of an amino group of an amino acid into a keto acid. Alanine aminotransferase…”
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Procaspase-activating compound-1 induces apoptosis in Trypanosoma cruzi by de Castro, Emanuella, Reus, Thamile Luciane, de Aguiar, Alessandra Melo, Ávila, Andrea Rodrigues, de Arruda Campos Brasil de Souza, Tatiana

“…Some therapeutics for parasitic, cardiac and neurological diseases activate apoptosis. Therefore, the study of apoptotic proteins in pathogenic organisms is…”
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Cross-linking mass spectrometry reveals structural insights of the glutamine synthetase from Leishmania braziliensis by de Lima, Jhenifer Yonara, Santos, Marlon Dias Mariano, Murakami, Mario Tyago, Carvalho, Paulo Costa, de Souza, Tatiana de Arruda Campos Brasil

“…Leishmaniasis is a neglected tropical disease caused by the parasite Leishmania braziliensis, commonly found in Brazil and associated with cutaneous and…”
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Should COVID-19 be branded to viral thrombotic fever? by Costa-Filho, Rubens Carmo, Castro-Faria Neto, Hugo Caire, Mengel, José, Pelajo-Machado, Marcelo, Martins, Marco Aurélio, Leite, Érica Távora, Mendonça-Filho, Hugo Tannus, de Souza, Tatiana de Arruda Campos Brasil, Bello, Gonzalo Bentacor, Leite, José Paulo Gagliardi

“…Coronaviruses can cause a diverse array of clinical manifestations, from fever with symptoms of the common cold to highly lethal severe acute respiratory…”
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l-Asparaginase from Erwinia carotovora: insights about its stability and activity by Faret, Marcele, de Morais, Stephanie Bath, Zanchin, Nilson Ivo Tonin, de Souza, Tatiana de Arruda Campos Brasil

“…Enzymatic prospection indicated that l -asparaginase from Erwinia carotovora (ECAR-LANS) posses low glutaminase activity and much effort has been made to…”
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Identification, Molecular and Functional Characterization of Calmodulin Gene of Phytomonas serpens 15T that Shares High Similarity with its Pathogenic Counterparts Trypanosoma cruzi by de Arruda Campos Brasil de Souza, Tatiana, Graça-de Souza, Viviane Krominski, Lancheros, César Armando Contreras, Monteiro-Góes, Viviane, Krieger, Marco Aurélio, Goldenberg, Samuel, Yamauchi, Lucy Megumi, Yamada-Ogatta, Sueli Fumie

“…In trypanosomatids, Ca 2+ -binding proteins can affect parasite growth, differentiation and invasion. Due to their importance for parasite maintenance, they…”
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Refolding of metacaspase 5 from Trypanosoma cruzi, structural characterization and the influence of c-terminal in protein recombinant production by De Lima, Jhenifer Yonara, Santos, Marlon Dias Mariano dos, Andreassa, Emanuella de Castro, Kurt, Louise Ulrich, Carvalho, Paulo Costa, De Souza, Tatiana de Arruda Campos Brasil

“…Metacaspases are known to have a fundamental role in apoptosis-like, a programmed cellular death (PCD) in plants, fungi, and protozoans. The last includes…”
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In-solution behavior and protective potential of asparagine synthetase A from Trypanosoma cruzi by Souza Morini, Flávia, de Castro, Emanuella, de Morais, Stephanie Bath, Lancheros Contreras, Cesar, Pereira Weiler, Ana Valéria, Murakami, Mario Tyago, Pinge-Filho, Phileno, Yamada-Ogatta, Sueli Fumie, de Arruda Campos Brasil de Souza, Tatiana

“…•Recombinant Tc-AS-A is dimeric and stable in acidic environments.•Our structural inspection showed that Tc-AS-A has the same fold and quaternary arrangement…”
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Dissecting biochemical peculiarities of the ATPase activity of TcSub2, a component of the mRNA export pathway in Trypanosoma cruzi by Bittencourt, Ize de Aguiar, Serpeloni, Mariana, Hiraiwa, Priscila Mazzochi, de Arruda Campos Brasil de Souza, Tatiana, Ávila, Andréa Rodrigues

“…The RNA helicase DEAD-box protein Sub2 (yeast)/UAP56 (mammals) is conserved across eukaryotes and is essential for mRNA export in trypanosomes. Despite the…”
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Structure and Mechanism of Dimer–Monomer Transition of a Plant Poly(A)-Binding Protein upon RNA Interaction: Insights into Its Poly(A) Tail Assembly by Domingues, Mariane Noronha, Sforça, Mauricio Luis, Soprano, Adriana Santos, Lee, Jack, de Souza, Tatiana de Arruda Campos Brasil, Cassago, Alexandre, Portugal, Rodrigo Villares, de Mattos Zeri, Ana Carolina, Murakami, Mario Tyago, Sadanandom, Ari, de Oliveira, Paulo Sergio Lopes, Benedetti, Celso Eduardo

“…Poly(A)-binding proteins (PABPs) play crucial roles in mRNA biogenesis, stability, transport and translational control in most eukaryotic cells. Although…”
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Identification of potential targets for an anticoagulant pectin by Santana, Aline Guimarães, Gracher, Ana Helena Pereira, Rüdiger, André Luis, Zanchin, Nilson Ivo Tonin, Carvalho, Paulo Costa, Cipriani, Thales Ricardo, de Arruda Campos Brasil de Souza, Tatiana

“…Heparin is a sulfated polysaccharide of animal origin showing excellent anticoagulant properties. Although it strongly inhibits the coagulation cascade, its…”
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