Search Results - "Souza, Scott"

Genetic mapping reveals Nfkbid as a central regulator of humoral immunity to Toxoplasma gondii by Souza, Scott P, Splitt, Samantha D, Sànchez-Arcila, Juan C, Alvarez, Julia A, Wilson, Jessica N, Wizzard, Safuwra, Luo, Zheng, Baumgarth, Nicole, Jensen, Kirk D C

“…Protective immunity to parasitic infections has been difficult to elicit by vaccines. Among parasites that evade vaccine-induced immunity is Toxoplasma gondii,…”
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Non-Classical Monocytes and Monocyte Chemoattractant Protein-1 (MCP-1) Correlate with Coronary Artery Calcium Progression in Chronically HIV-1 Infected Adults on Stable Antiretroviral Therapy by Zungsontiporn, Nath, Tello, Raquel R, Zhang, Guangxiang, Mitchell, Brooks I, Budoff, Matthew, Kallianpur, Kalpana J, Nakamoto, Beau K, Keating, Sheila M, Norris, Philip J, Ndhlovu, Lishomwa C, Souza, Scott A, Shikuma, Cecilia M, Chow, Dominic C

“…Persistent inflammation and immune activation has been hypothesized to contribute to increased prevalence of subclinical atherosclerosis and cardiovascular…”
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Impact of antiretroviral therapy intensification with C-C motif chemokine receptor 5 antagonist maraviroc on HIV-associated neurocognitive impairment by Shikuma, Cecilia M, Wojna, Valerie, De Gruttola, Victor, Siriwardhana, Chathura, Souza, Scott A, Rodriguez-Benitez, Rosa J, Turner, Emilee H, Kallianpur, Kalpana, Bolzenius, Jacob, Chow, Dominic, Matos, Miriam, Shiramizu, Bruce, Clements, Danielle M, Premeaux, Thomas A, Ndhlovu, Lishomwa C, Paul, Robert

“…Chemokine receptor CCR5 is the principal co-receptor for entry of M-tropic HIV virus into immune cells. It is expressed in the central nervous system and may…”
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The GPI sidechain of Toxoplasma gondii inhibits parasite pathogenesis by Alvarez, Julia A, Gas-Pascual, Elisabet, Malhi, Sahil, Sánchez-Arcila, Juan C, Njume, Ferdinand Ngale, van der Wel, Hanke, Zhao, Yanlin, García-López, Laura, Ceron, Gabriella, Posada, Jasmine, Souza, Scott P, Yap, George S, West, Christopher M, Jensen, Kirk D C

“…Glycosylphosphatidylinositols (GPIs) are highly conserved anchors for eukaryotic cell surface proteins. The apicomplexan parasite, , is a widespread…”
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Short Communication: Metformin Reduces CD4 T Cell Exhaustion in HIV-Infected Adults on Suppressive Antiretroviral Therapy by Shikuma, Cecilia M, Chew, Glen M, Kohorn, Lindsay, Souza, Scott A, Chow, Dominic, SahBandar, Ivo Novita, Park, Eun-Young, Hanks, Nancy, Gangcuangco, Louie Mar A, Gerschenson, Mariana, Ndhlovu, Lishomwa C

“…Increased negative immune checkpoint receptors (NCR) on T cells are linked to T cell exhaustion, dysfunctional effector responses, and HIV viral persistence…”
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Variation in CD8 T cell IFNγ differentiation to strains of Toxoplasma gondii is characterized by small effect QTLs with contribution from ROP16 by Kongsomboonvech, Angel K, García-López, Laura, Njume, Ferdinand, Rodriguez, Felipe, Souza, Scott P, Rosenberg, Alex, Jensen, Kirk D C

“…induces a strong CD8 T cell response characterized by the secretion of IFNγ that promotes host survival during infection. The initiation of CD8 T cell IFNγ…”
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Frailty Is Associated With Insulin Resistance in Chronic Human Immunodeficiency Virus Infection by Chow, Dominic C, Bernas, Monika Anna, Gangcuangco, Louie Mar, Huynh, Jason, Kohorn, Lindsay B, Kallianpur, Kalpana J, Souza, Scott A, Shiramizu, Bruce, Ndhlovu, Lishomwa C, Shikuma, Cecilia M

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PD-L1, TIM-3, and CTLA-4 Blockade Fails To Promote Resistance to Secondary Infection with Virulent Strains of Toxoplasma gondii by Splitt, Samantha D, Souza, Scott P, Valentine, Kristen M, Castellanos, Brayan E, Curd, Andrew B, Hoyer, Katrina K, Jensen, Kirk D C

“…T cell exhaustion is a state of hyporesponsiveness that develops during many chronic infections and cancer. Neutralization of inhibitory receptors, or…”
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Effects of Brief Adjunctive Metformin Therapy in Virologically Suppressed HIV-Infected Adults on Polyfunctional HIV-Specific CD8 T Cell Responses to PD-L1 Blockade by Chew, Glen M, Padua, Ana Joy P, Chow, Dominic C, Souza, Scott A, Clements, Danielle M, Corley, Michael J, Pang, Alina P S, Alejandria, Marissa M, Gerschenson, Mariana, Shikuma, Cecilia M, Ndhlovu, Lishomwa C

“…Targeting inhibitory immune checkpoint receptor pathways has shown remarkable success in improving anticancer T cell responses for the elimination of tumors…”
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S100B and its association with HIV-associated neurocognitive disorders by Limpruttidham, Nath, Mitchell, Brooks I., Kallianpur, Kalpana J., Nakamoto, Beau K., Souza, Scott A., Shiramizu, Bruce, Ndhlovu, Lishomwa C., Chow, Dominic C., Shikuma, Cecilia M.

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High 25-hydroxyvitamin D is associated with unexpectedly high plasma inflammatory markers in HIV patients on antiretroviral therapy by Gangcuangco, Louie Mar A., Kohorn, Lindsay B., Chow, Dominic C., Keating, Sheila M., Norris, Philip J., Nagamine, Lorna S., Ndhlovu, Lishomwa C., Souza, Scott A., Kallianpur, Kalpana J., Shikuma, Cecilia M.

“…Inflammation associated with low 25-hydroxyvitamin D (25(OH)D) is associated with increased morbidity and mortality among HIV-infected patients with vitamin D…”
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CD4/CD8 Ratio Predicts Peripheral Fat in HIV-Infected Population by Riangwiwat, Tanawan, Kohorn, Lindsay B, Chow, Dominic C, Souza, Scott A, Ndhlovu, Lishomwa C, Wong, Jennifer W H, Gangcuangco, Louie Mar, Shikuma, Cecilia M

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Role of the Veterans Aging Cohort Study Index in Assessing Total Atherosclerotic Burden by Chow, Dominic, Thomas, Benjamin S., Liang, Chin-yuan, Souza, Scott C., Nakamoto, Beau K., Parikh, Nisha I., Shikuma, Cecilia

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Effect of extended-release niacin on hormone-sensitive lipase and lipoprotein lipase in patients with HIV-associated lipodystrophy syndrome by Chow, Dominic C

“…Investigates the effect of extended-release niacin (ERN) on adipose hormone-sensitive lipase (HSL) and lipoprotein lipase (LPL) expression in patients with…”
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Red blood cell distribution width as an easily measurable biomarker of persistent inflammation and T cell dysregulation in antiretrovirally treated HIV-infected adults by Zhang, Zao, Chew, Glen M, Shikuma, Cecilia M, Gangcuangco, Louie Mar A, Souza, Scott A, Shiramizu, Bruce, Nakamoto, Beau K, Gong, Ting, Mannem, Santhosh R, Mitchell, Brooks I, Kallianpur, Kalpana J, Ndhlovu, Lishomwa C, Chow, Dominic C

“…Chronic inflammation and immune dysfunction occur in human immunodeficiency virus (HIV)-infection despite stable antiretroviral therapy (ART). Red blood cell…”
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Non-classical monocytes predict progression of carotid artery bifurcation intima-media thickness in HIV-infected individuals on stable antiretroviral therapy by Chow, Dominic C, Kagihara, Jamie M, Zhang, Guangxiang, Souza, Scott A, Hodis, Howard N, Li, Yanjie, Mitchell, Brooks I, Nakamoto, Beau K, Kallianpur, Kalpana J, Keating, Sheila M, Norris, Philip J, Kohorn, Lindsay B, Ndhlovu, Lishomwa C, Shikuma, Cecilia M

“…Inflammation may contribute to cardiovascular disease (CVD) among antiretrovirally suppressed HIV-infected individuals. We assessed relationships of monocyte,…”
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HIV-Associated Wasting in the Era of Highly Active Antiretroviral Therapy: A Syndrome of Residual HIV Infection in Monocytes and Macrophages? by Shikuma, Cecilia M., Valcour, Victor G., Ratto-Kim, Silvia, Williams, Andrew E., Souza, Scott, Gerschenson, Mariana, Day, Larry, Kim, Jerome H., Shiramizu, Bruce

“…Human immunodeficiency virus (HIV) infection in peripheral blood mononuclear cells (PBMCs) might be influencing the development of wasting in the era of potent…”
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Impact of ART intensification with CCR5 antagonist maraviroc on HIV-associated neurocognitive impairment by Shikuma, Cecilia M., Wojna, Valerie, De Gruttola, Victor, Siriwardhana, Chathura, Souza, Scott, Rodriguez-Benitez, Rosa J., Turner, Emilee H., Kallianpur, Kalpana, Bolzenius, Jacob, Chow, Dominic, Matos, Miriam, Shiramizu, Bruce, Clements, Danielle M., Premeaux, Thomas A., Ndhlovu, Lishomwa C., Paul, Robert

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Peripheral blood HIV DNA is associated with atrophy of cerebellar and subcortical gray matter by Kallianpur, Kalpana J, Shikuma, Cecilia, Kirk, Gregory R, Shiramizu, Bruce, Valcour, Victor, Chow, Dominic, Souza, Scott, Nakamoto, Beau, Sailasuta, Napapon

“…OBJECTIVE:We evaluated regional brain volumes and cerebral metabolite levels as correlates of HIV DNA in peripheral blood mononuclear cells (PBMCs). METHODS:In…”
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The replication-competent HIV reservoir is detectable in circulating monocytes and is increased in ART-suppressed chronic HIV-infected individuals with cognitive impairment by Mitchell, Brooks I., Laws, Elizabeth I., Souza, Scott A., Paul, Robert H., Milne, Cris I.P., Nakamoto, Beau K., Shikuma, Cecilia M., Ndhlovu, Lishomwa C.

“…Abstract Background Measuring replication-competent HIV (rcHIV) in monocytes (MO) in the setting of antiretroviral therapy (ART)-suppression, remains a topic…”
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