Search Results - "Souza, Paul de"

The Effect of Drug Loading on Micelle Properties: Solid‐State NMR as a Tool to Gain Structural Insight by Callari, Manuela, De Souza, Paul L., Rawal, Aditya, Stenzel, Martina H.

“…The present study highlights the importance of understanding the structural changes of micelles induced by drug loading on their physico‐chemical properties. A…”
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Prognostic and Predictive Value of CCND1/Cyclin D1 Amplification in Breast Cancer With a Focus on Postmenopausal Patients: A Systematic Review and Meta-Analysis by Jeffreys, Sarah A., Becker, Therese M., Khan, Sarah, Soon, Patsy, Neubauer, Hans, de Souza, Paul, Powter, Branka

“…Background Up to 80% of breast cancers (BCa) are estrogen receptor positive and current treatments target the estrogen receptor (endocrine therapies) and/or…”
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Droplet Digital PCR Based Androgen Receptor Variant 7 (AR-V7) Detection from Prostate Cancer Patient Blood Biopsies by Ma, Yafeng, Luk, Alison, Young, Francis P, Lynch, David, Chua, Wei, Balakrishnar, Bavanthi, de Souza, Paul, Becker, Therese M

“…Androgen receptor splice variant V7 (AR-V7) was recently identified as a valuable predictive biomarker in metastatic castrate-resistant prostate cancer. Here,…”
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Detection of AR-V7 in Liquid Biopsies of Castrate Resistant Prostate Cancer Patients: A Comparison of AR-V7 Analysis in Circulating Tumor Cells, Circulating Tumor RNA and Exosomes by Nimir, Mohammed, Ma, Yafeng, Jeffreys, Sarah A, Opperman, Thomas, Young, Francis, Khan, Tanzila, Ding, Pei, Chua, Wei, Balakrishnar, Bavanthi, Cooper, Adam, De Souza, Paul, Becker, Therese M

“…Detection of androgen receptor (AR) variant 7 (AR-V7) is emerging as a clinically important biomarker in castrate resistant prostate cancer (CRPC). Detection…”
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Efficacy and Safety of Pazopanib in Patients With Metastatic Renal Cell Carcinoma by HUTSON, Thomas E, DAVIS, Ian D, PANDITE, Lini, FIGLIN, Robert A, MACHIELS, Jean-Pascal H, DE SOUZA, Paul L, ROTTEY, Sylvie, HONG, Bao-Fa, EPSTEIN, Richard J, BAKER, Katherine L, MCCANN, Lauren, CROFTS, Theresa

“…Inactivation of the von Hippel-Lindau gene in clear-cell renal cell carcinomas (RCC) leads to overexpression of hypoxia inducible factor, a transcription…”
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Folate Conjugation to Polymeric Micelles via Boronic Acid Ester to Deliver Platinum Drugs to Ovarian Cancer Cell Lines by Scarano, Wei, Duong, Hien T. T, Lu, Hongxu, De Souza, Paul L, Stenzel, Martina H

“…In this study, a novel technique was used for the reversible attachment of folic acid on the surface of polymeric micelles for a tumor-specific drug delivery…”
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Risk factors for erectile dysfunction in a cohort of 108 477 Australian men by Weber, Marianne F, Smith, David P, OˈConnell, Dianne L, Patel, Manish I, Souza, Paul L, Sitas, Freddy, Banks, Emily

“…Objectives: To quantify relationships between erectile dysfunction (ED), ageing and health and lifestyle factors for men aged 45 years and older. Design:…”
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Improved ovarian cancer EMT-CTC isolation by immunomagnetic targeting of epithelial EpCAM and mesenchymal N-cadherin by Po, Joseph W, Roohullah, Aflah, Lynch, David, DeFazio, Anna, Harrison, Michelle, Harnett, Paul R, Kennedy, Catherine, de Souza, Paul, Becker, Therese M

“…Epithelial cell adhesion molecule (EpCAM)-targeted capture remains the most common isolation strategy for circulating tumor cells (CTCs). However,…”
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717 A phase 1/2 study of AU-007, a monoclonal antibody (mAb) that binds to IL-2 and inhibits CD25 binding, in patients with advanced solid tumors: interim results from dose escalation by Frentzas, Sophia, Ahern, Elizabeth, Weickhardt, Andrew, Haydon, Andrew, Powderly, John, Rasco, Drew, McKean, Meredith, Souza, Paul de, Wyant, Timothy, Tang, Jenny, Richards, Lori, Knickerbocker, Aron, Amit, Inbar, Ofran, Yanay, Vasselli, James

“…BackgroundAU-007 is a computationally designed mAb that binds IL-2 on its CD25 binding epitope. AU-007 bound IL-2 (A/IL-2) cannot bind to trimeric (CD25,…”
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Endocrine Resistance in Breast Cancer: The Role of Estrogen Receptor Stability by Jeffreys, Sarah A, Powter, Branka, Balakrishnar, Bavanthi, Mok, Kelly, Soon, Patsy, Franken, André, Neubauer, Hans, de Souza, Paul, Becker, Therese M

“…Therapy of hormone receptor positive breast cancer (BCa) generally targets estrogen receptor (ER) function and signaling by reducing estrogen production or by…”
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Role of the Akt pathway in prostate cancer by de Souza, Paul L, Russell, Pamela J, Kearsley, John

“…The Akt pathway, or more accurately, network, has assumed increasing importance with the understanding that it represents a key role in cancer cell survival…”
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Ras Isoprenylation and pAkt Inhibition by Zoledronic Acid and Fluvastatin Enhances Paclitaxel Activity in T24 Bladder Cancer Cells by Li, Shaojuan, De Souza, Paul

“…Bisphosphonates interfere with the mevalonate pathway and inhibit the prenylation of small GTP-binding proteins such as ras and rap. We hypothesized that…”
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Cancer-Related Fatigue in Women With Breast Cancer: Outcomes of a 5-Year Prospective Cohort Study by GOLDSTEIN, David, BENNETT, Barbara K, MCCOURT, Junie, FRIEDLANDER, Michael, HICKIE, Ian B, LLOYD, Andrew R, WEBBER, Kate, BOYLE, Fran, DE SOUZA, Paul L, WILCKEN, Nicholas R. C, SCOTT, Elizabeth M, TOPPLER, Ruth, MURIE, Penelope, O'MALLEY, Linda

“…Prolonged and disabling fatigue is prevalent after cancer treatment, but the early natural history of cancer-related fatigue (CRF) has not been systematically…”
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Polymers with platinum drugs and other macromolecular metal complexes for cancer treatment by Callari, Manuela, Aldrich-Wright, Janice R., de Souza, Paul L., Stenzel, Martina H.

“…Metal-based anticancer drugs, in particular platinum-drugs, have been investigated for the treatment of cancer for the last 40 years. A small set of…”
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Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study by Ryan, Charles J, Prof, Smith, Matthew R, Prof, Fizazi, Karim, Prof, Saad, Fred, Prof, Mulders, Peter F A, Prof, Sternberg, Cora N, MD, Miller, Kurt, Prof, Logothetis, Christopher J, Prof, Shore, Neal D, MD, Small, Eric J, Prof, Carles, Joan, MD, Flaig, Thomas W, MD, Taplin, Mary-Ellen, MD, Higano, Celestia S, Prof, de Souza, Paul, Prof, de Bono, Johann S, Prof, Griffin, Thomas W, MD, De Porre, Peter, MD, Yu, Margaret K, MD, Park, Youn C, PhD, Li, Jinhui, PhD, Kheoh, Thian, PhD, Naini, Vahid, PharmD, Molina, Arturo, MD, Rathkopf, Dana E, MD

“…Summary Background Abiraterone acetate plus prednisone significantly improved radiographic progression-free survival compared with placebo plus prednisone in…”
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Molecular Biomarkers in Glioblastoma: A Systematic Review and Meta-Analysis by Sareen, Heena, Ma, Yafeng, Becker, Therese M, Roberts, Tara L, de Souza, Paul, Powter, Branka

“…Background: Glioblastoma (GBM) is a highly aggressive cancer with poor prognosis that needs better treatment modalities. Moreover, there is a lack of reliable…”
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Dual-drug delivery of curcumin and platinum drugs in polymeric micelles enhances the synergistic effects: a double act for the treatment of multidrug-resistant cancer by Scarano, Wei, de Souza, Paul, Stenzel, Martina H

“…Combinational chemotherapy is often used to prevent drug induced resistance in cancer. The aim of this work is to test whether the co-delivery of drugs within…”
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Pazopanib versus Sunitinib in Metastatic Renal-Cell Carcinoma by Motzer, Robert J, Hutson, Thomas E, Cella, David, Reeves, James, Hawkins, Robert, Guo, Jun, Nathan, Paul, Staehler, Michael, de Souza, Paul, Merchan, Jaime R, Boleti, Ekaterini, Fife, Kate, Jin, Jie, Jones, Robert, Uemura, Hirotsugu, De Giorgi, Ugo, Harmenberg, Ulrika, Wang, Jinwan, Sternberg, Cora N, Deen, Keith, McCann, Lauren, Hackshaw, Michelle D, Crescenzo, Rocco, Pandite, Lini N, Choueiri, Toni K

“…A number of agents are now approved for the treatment of renal cancer. A comparison of two agents, pazopanib and sunitinib, showed similar levels of antitumor…”
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Abiraterone in Metastatic Prostate Cancer without Previous Chemotherapy by Ryan, Charles J, Smith, Matthew R, de Bono, Johann S, Molina, Arturo, Logothetis, Christopher J, de Souza, Paul, Fizazi, Karim, Mainwaring, Paul, Piulats, Josep M, Ng, Siobhan, Carles, Joan, Mulders, Peter F.A, Basch, Ethan, Small, Eric J, Saad, Fred, Schrijvers, Dirk, Van Poppel, Hendrik, Mukherjee, Som D, Suttmann, Henrik, Gerritsen, Winald R, Flaig, Thomas W, George, Daniel J, Yu, Evan Y, Efstathiou, Eleni, Pantuck, Allan, Winquist, Eric, Higano, Celestia S, Taplin, Mary-Ellen, Park, Youn, Kheoh, Thian, Griffin, Thomas, Scher, Howard I, Rathkopf, Dana E

“…Abiraterone has been approved as second-line chemotherapy in patients with metastatic castration-resistant prostate cancer. This study shows significant…”
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Comparison of neutrophil to lymphocyte ratio and prognostic nutritional index with other clinical and molecular biomarkers for prediction of glioblastoma multiforme outcome by Garrett, Celine, Becker, Therese M, Lynch, David, Po, Joseph, Xuan, Wei, Scott, Kieran F, de Souza, Paul

“…Objective Pre- and post-operative neutrophil to lymphocyte ratio (NLR) and prognostic nutritional index (PNI) and other prognostic clinicopathological…”
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