Search Results - "Souza, Maria Cecilia B. V. de"

Synthesis and anti- Trypanosoma cruzi activity of derivatives from nor-lapachones and lapachones by da Silva Júnior, Eufrânio N., de Souza, Maria Cecília B.V., Fernandes, Michelle C., Menna-Barreto, Rubem F.S., Pinto, Maria do Carmo F.R., de Assis Lopes, Francisco, de Simone, Carlos Alberto, Andrade, Carlos Kleber Z., Pinto, Antônio V., Ferreira, Vitor F., de Castro, Solange L.

“…New naphthoquinone derivatives were synthesized and assayed against bloodstream trypomastigote forms of Trypanosoma cruzi, the etiological agent of Chagas’…”
Get full text

Synthesis, HIV-RT inhibitory activity and SAR of 1 -benzyl-1H-1,2,3 -triazole derivatives of carbohydrates by DA SILVA, Fernando De C, DE SOUZA, Maria Cecilia B. V, RODRIGUES, Carlos R, FERREIRA, Vitor F, FRUGULHETTI, Izabel I. P, CASTRO, Helena C, SOUZA, Silmara L. De O, DE SOUZA, Thiago Moreno L, RODRIGUES, Diego Q, SOUZA, Alessandra M. T, ABREU, Paula A, PASSAMANI, Fabiana

“…This paper describes the synthesis of several 1-benzyl-1H-1,2,3-triazoles attached to different carbohydrate templates and their in vitro inhibitory profile…”
Get full text

Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi by da Silva, Eufrânio N., Menna-Barreto, Rubem F.S., Pinto, Maria do Carmo F.R., Silva, Raphael S.F., Teixeira, Daniel V., de Souza, Maria Cecília B.V., De Simone, Carlos Alberto, De Castro, Solange L., Ferreira, Vitor F., Pinto, Antônio V.

“…[1,2,3]-Triazole derivatives of nor-β-lapachone were synthesized and assayed against the infective bloodstream trypomastigote form of Trypanosoma cruzi, the…”
Get full text

Antivenom Effects of 1,2,3-Triazoles against Bothrops jararaca and Lachesis muta Snakes by Fuly, André Lopes, Sanchez, Eladio F., Ferreira, Vitor F., Cunha, Anna C., Jordão, Alessandro K., Campos, Vinícius R., Carvalho, Carla, Moura, Laura A., Domingos, Thaisa F. S., de Souza, Maria Cecília B. V.

“…Snake venoms are complex mixtures of proteins of both enzymes and nonenzymes, which are responsible for producing several biological effects. Human…”
Get full text

Synthesis and potent antitumor activity of new arylamino derivatives of nor-β-lapachone and nor-α-lapachone by da Silva Júnior, Eufrânio N., de Souza, Maria Cecília B.V., Pinto, Antônio V., Pinto, Maria do Carmo F.R., Goulart, Marilia O.F., Barros, Francisco W.A., Pessoa, Claudia, Costa-Lotufo, Letícia V., Montenegro, Raquel C., de Moraes, Manoel O., Ferreira, Vitor F.

“…Several arylamino derivatives of nor-β-lapachone and one derivative of nor-α-lapachone were synthesized in moderate to high yields and found to show very…”
Get full text

Synthesis and anticancer activities of some novel 2-(benzo[d]thiazol-2-yl)-8-substituted-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones by REIS, Raisa Da R, AZEVEDO, Elisa C, DE SOUZA, Alessandra M. T, DE CARVALHO, Natasha C, CASTRO, Helena C, RODRIGUES, Carlos R, VASCONCELOS, Thatyana R. A, DE SOUZA, Maria Cecilia B. V, FERREIRA, Vitor Francisco, MONTENEGRO, Raquel C, JERSIA ARAUJO, Ana, PESSOA, Cláudia, COSTA-LOTUFO, Leticia V, DE MORAES, Manoel O, FILHO, José D. B. M

“…A series of 2-(benzo[d]thiazol-2-yl)-8-substituted-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones (3a-g) have been synthesized and evaluated for their in vitro…”
Get full text

Study on the regioselectivity of the N-ethylation reaction of N -benzyl-4-oxo-1,4-dihydroquinoline-3-carboxamide by Batalha, Pedro N, Forezi, Luana da S M, Freitas, Maria Clara R, Tolentino, Nathalia M de C, Orestes, Ednilsom, Carneiro, José Walkimar de M, Boechat, Fernanda da C S, de Souza, Maria Cecília B V

“…4-Oxoquinolines are a class of organic substances of great importance in medicinal chemistry, due to their biological and synthetic versatility…”
Get full text

Oxoquinoline acyclonucleoside phosphonate analogues as a new class of specific inhibitors of human immunodeficiency virus type 1 by Faro, Letícia V., de Almeida, Jéssica M., Cirne-Santos, Cláudio C., Giongo, Viveca A., Castello-Branco, Luís R., Oliveira, Ingrid de B., Barbosa, Juliana E.F., Cunha, Anna C., Ferreira, Vítor F., de Souza, Marcos C., Paixão, Izabel C.N.P., de Souza, Maria Cecília B.V.

“…In this work we report the synthesis and in vitro anti-HIV-1 evaluation of a new class of oxoquinoline acyclonucleoside phosphonate analogues ethyl…”
Get full text

Bioactive 1,2,3‐Triazoles: An Account on their Synthesis, Structural Diversity and Biological Applications by S. M. Forezi, Luana, Lima, Carolina G. S., Amaral, Adriane A. P., Ferreira, Patricia G., Souza, Maria Cecília B. V., Cunha, Anna C., C. da Silva, Fernando, Ferreira, Vitor F.

“…The triazole heterocycle is a privileged scaffold in medicinal chemistry, since its structure is present in a large number of biologically active molecules,…”
Get full text

Exploring N-Acylhydrazone Derivatives Against Clinical Resistant Bacterial Strains by Lannes, Andressa C., Leal, Bruno, Novais, Juliana S., Lione, Viviane, Monteiro, Georgia C. T. S., Lourenço, André L., Sathler, Plínio C., Jordão, Alessandro K., Rodrigues, Carlos R., Cabral, Lúcio M., Cunha, Anna Claudia, Campos, Vinicius, Ferreira, Vítor F., de Souza, Maria Cecília B. V., Santos, Dilvani O., Castro, Helena C.

“…Bacterial multiresistance is a health problem worldwide that demands new antimicrobials for treating bacterial-related infections. In this study, we evaluated…”
Get full text

Synthesis and anti-HSV-1 activity of quinolonic acyclovir analogues by Lucero, Bianca d’A., Gomes, Claudia Regina B., Frugulhetti, Izabel Christina de P.P., Faro, Letícia V., Alvarenga, Lise, de Souza, Maria Cecília B.V., de Souza, Thiago M.L., Ferreira, Vitor F.

“…Several new acyclonucleosides, 1-[(2-hydroxy-ethoxy)methyl]-3-carbethoxy-4(1 H)quinolones ( 2a– l) and 1-[(2-hydroxy-ethoxy)methyl]-4(1…”
Get full text

A New Insight into the Catalytic Decomposition of Ethyl Diazoacetate in the Presence of meso-Tetraarylporphyrin (=5,10,15,20-Tetraaryl-21H,23H-porphine) Complexes by Gomes, Ana T. P. C., Leão, Raquel A. C., Alonso, Cristina M. A., Neves, Maria G. P. M. S., Faustino, Maria A. F., Tomé, Augusto C., Silva, Artur M. S., Pinheiro, Sergio, de Souza, Maria Cecília B. V., Ferreira, Vítor F., Cavaleiro, José A. S.

“…The decomposition of ethyl diazoacetate by several catalysts in the presence of meso‐tetraarylporphyrin complexes with different electronic features was…”
Get full text

Catalytic carbene insertion into an aminoporphyrin and formation of a new chiral supramolecular porphyrin system by Gomes, Ana T.P.C., Almeida Paz, Filipe A., Neves, Maria G.P.M.S., Tomé, Augusto C., Silva, Artur M.S., de Souza, Maria Cecília B.V., Ferreira, Vítor F., Cavaleiro, José A.S.

“…The catalytic insertion of ethyl diazoacetate into a porphyrin derivative bearing an NH 2 substituent, in the presence of a Rh-based catalyst, was…”
Get full text

Design, Synthesis and Antileishmanial Activity of Naphthotriazolyl-4- Oxoquinolines by Oliveira, Vanessa G, Dos Santos Faiões, Viviane, Gonçalves, Gabrieli B R, Lima, Miriam F O, Boechat, Fernanda C S, Cunha, Anna C, de Andrade-Neto, Valter V, de C da Silva, Fernando, Torres-Santos, Eduardo C, de Souza, Maria Cecília B V

“…Leishmaniasis is a neglected public health problem caused by several protozoanspecies of the genus Leishmania. The therapeutic arsenal for treating…”
Get more information

Supramolecular assembly of (Z)-ethyl 2-cyano-3-((4-fluorophenyl)amino) acrylate, crystal structure, Hirshfeld surface analysis and DFT studies by Matos, Catiúcia R.M.O., Vitorino, Letícia S., de Oliveira, Pedro H.R., de Souza, Maria Cecília B.V., Cunha, Anna C., Boechat, Fernanda da C.S., Resende, Jackson A.L.C., Carneiro, José Walkimar de M., Ronconi, Célia M.

“…A mixture of the E and Z isomers of ethyl 2-cyano-3-((4-fluorophenyl)amino) acrylate was synthesized and characterized by elemental analysis, attenuated total…”
Get full text

Synthesis, cytotoxicity and mechanistic evaluation of 4-oxoquinoline-3-carboxamide derivatives: finding new potential anticancer drugs by Forezi, Luana da S M, Tolentino, Nathalia M C, de Souza, Alessandra M T, Castro, Helena C, Montenegro, Raquel C, Dantas, Rafael F, Oliveira, Maria E I M, Silva, Jr, Floriano P, Barreto, Leilane H, Burbano, Rommel M R, Abrahim-Vieira, Bárbara, de Oliveira, Riethe, Ferreira, Vitor F, Cunha, Anna C, Boechat, Fernanda da C S, de Souza, Maria Cecília B V

“…As part of a continuing search for new potential anticancer candidates, we describe the synthesis, cytotoxicity and mechanistic evaluation of a series of…”
Get full text

Antiplatelet properties of novel N-substituted-phenyl-1,2,3-triazole-4-acylhydrazone derivatives by Cunha, Anna C., Figueiredo, Juliana M., Tributino, Jorge L.M., Miranda, Ana L.P., Castro, Helena C., Zingali, Russolina B., Fraga, Carlos A.M., de Souza, Maria Cecı́lia B.V., Ferreira, Vitor F., Barreiro, Eliezer J.

“…This paper describes the design, synthesis and pharmacological evaluation of new N-acylhydrazone (NAH) compounds, belonging to the…”
Get full text

Drug repurposing for the treatment of COVID-19: Pharmacological aspects and synthetic approaches by Batalha, Pedro N., Forezi, Luana S.M., Lima, Carolina G.S., Pauli, Fernanda P., Boechat, Fernanda C.S., de Souza, Maria Cecília B.V., Cunha, Anna C., Ferreira, Vitor F., da Silva, Fernando de C.

“…[Display omitted] •The repositioning of approved drugs is a promising approach for treating COVID-19.•Several approved drugs have shown anti-SARS-CoV-2…”
Get full text

Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines by Cardoso, Mariana F.C., Rodrigues, Patrícia C., Oliveira, Maria Eduarda I.M., Gama, Ivson L., da Silva, Illana M.C.B., Santos, Isabela O., Rocha, David R., Pinho, Rosa T., Ferreira, Vitor F., de Souza, Maria Cecília B.V., da Silva, Fernando de C., Silva-Jr, Floriano Paes

“…Leukemia is the most common blood cancer, and its development starts at diverse points, leading to distinct subtypes that respond differently to therapy. This…”
Get full text

( E )-1-Ethyl-4-oxo- N ′-(4-pyridylmethylene)-1,4-dihydroquinoline-3-carbohydrazide by Santos, Fernanda da C., Batalha, Pedro Netto, Cunha, Anna Claudia, Alão, Rafael A., Ferreira, Vitor Francisco, Souza, Maria Cecilia B. V. de, Santos, Sauli

Get full text