Search Results - "Souza, Marcus"

Quinoxaline Nucleus: A Promising Scaffold in Anti-cancer Drug Discovery by Pinheiro, Alessandra C, Mendonça Nogueira, Thais C, de Souza, Marcus V N

“…Heterocyclic compounds are a class of substances, which play a critical role in modern drug discovery being incorporated in the structure of a large variety of…”
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Application of nitriles on the synthesis of 1,3-oxazoles, 2-oxazolines, and oxadiazoles: An update from 2014 to 2021 by Facchinetti, Victor, Gomes, Claudia R.B., de Souza, Marcus V.N.

“…The importance of 5-membered azaheterocycles is well established, especially in the medicinal chemistry field, as these nuclei are present in many marketed…”
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Synthesis and evaluation of copper(II) complexes with isoniazid-derived hydrazones as anticancer and antitubercular agents by Firmino, Gisele S. S., de Souza, Marcus V. N., Pessoa, Claudia, Lourenco, Maria C. S., Resende, Jackson A. L. C., Lessa, Josane A.

“…In this study, the N , N , O metal chelator 2-pyridinecarboxaldehydeisonicotinoyl hydrazone (HPCIH, 1 ) and its derivatives 2-acetylpyridine-(HAPIH 2 ),…”
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Current leishmaniasis drug discovery by Pinheiro, Alessandra Campbell, de Souza, Marcus Vinícius Nora

“…Leishmaniasis is a complex protozoan infectious disease and, associated with malnutrition, poor health services and unavailability of prophylactic control…”
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Synthesis, biological activity, and mechanism of action of new 2-pyrimidinyl hydrazone and N-acylhydrazone derivatives, a potent and new classes of antileishmanial agents by Coimbra, Elaine Soares, Nora de Souza, Marcus Vinícius, Terror, Mariana Sequetto, Pinheiro, Alessandra Campbell, da Trindade Granato, Juliana

“…In this work, we report the antileishmanial activity of 15 compounds based on 2-pyrimidinyl hydrazone and N-acylhydrazone derivatives, being 13 new compounds…”
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New FDA oncology small molecule drugs approvals in 2020: Mechanism of action and clinical applications by Cristina Mendonça Nogueira, Thais, Vinicius Nora de Souza, Marcus

“…[Display omitted] In 2020, fifty-three new drugs, including forty small-molecules (thirty-six new chemical entities and four new diagnostic agents) and…”
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Analysis of the Leap Motion Controller’s Performance in Measuring Wrist Rehabilitation Tasks Using an Industrial Robot Arm Reference by Gonçalves, Rogério S., Souza, Marcus R. S. B. de, Carbone, Giuseppe

“…The Leap Motion Controller (LMC) is a low-cost markerless optical sensor that performs measurements of various parameters of the hands that has been…”
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Design, Synthesis, and Molecular Docking Studies of New Quinoline-Thiazole Hybrids, Potential Leads in the Development of Novel Antileukemic Agents by Facchinetti, Victor, Gomes, Claudia Regina, Aboud, Karoline, Fiorot, Rodolfo, de Carvalho, Guilherme, Paier, Carlos Roberto, do Ó Pessoa, Caudia, Gomes, Anne Caroline, de Souza, Marcus Vinícius, Vasconcelos, Thatyana

“…This work describes the multigram-scale synthesis of the building-block N1 -(7-chloroquinolin4-yl)ethane-1,2-diamine via sonochemistry and its use in the…”
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Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives by Carvalho, Samir A., da Silva, Edson F., de Souza, Marcus V.N., Lourenço, Maria C.S., Vicente, Felipe R.

“…The present article describes a series of ten new trans-cinnamic acid hydrazide derivatives, which were synthesized and evaluated for their in vitro…”
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Design, synthesis and biological evaluation of (E)-2-(2-arylhydrazinyl)quinoxalines, a promising and potent new class of anticancer agents by Rodrigues, Felipe A.R., Bomfim, Igor da S., Cavalcanti, Bruno C., Pessoa, Claudia do Ó., Wardell, James L., Wardell, Solange M.S.V., Pinheiro, Alessandra C., Kaiser, Carlos Roland, Nogueira, Thais C.M., Low, John N., Gomes, Ligia R., de Souza, Marcus V.N.

“…A series of forty-seven quinoxaline derivatives, 2-(XYZC6H2CHN–NH)-quinoxalines, 1, have been synthesized and evaluated for their activity against four cancer…”
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2,8-bis(trifluoromethyl)quinoline analogs show improved anti-Zika virus activity, compared to mefloquine by Barbosa-Lima, Giselle, Moraes, Adriana M., Araújo, Adriele da S., da Silva, Emerson T., de Freitas, Caroline S., Vieira, Yasmine R., Marttorelli, Andressa, Neto, José Cerbino, Bozza, Patrícia T., de Souza, Marcus V.N., Souza, Thiago Moreno. L.

“…Zika virus (ZIKV), an arthropod-born Flavivirus, has been associated with a wide range of neurological diseases in adults, foetuses and neonates. Since no…”
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Synthesis, biological evaluation and mechanism of action of benzothiazole derivatives with aromatic hydrazone moiety, a new class of antileishmanial compounds by Coimbra, Elaine Soares, Antinarelli, Luciana M. R., Oliveira Lemos, Ari Sérgio, Silva Neto, Adolfo Firmino, Pinheiro, Alessandra Campbell, Souza, Marcus Vinícius Nora

“…Leishmaniasis is a disease caused by protozoa Leishmania spp., considered as a significant and urgent public health problem mainly in developing countries. In…”
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Mefloquine-Oxazolidine Derivatives: A New Class of Anticancer Agents by Rodrigues, Felipe A. R., Bomfim, Igor da S., Cavalcanti, Bruno C., Pessoa, Claudia, Goncalves, Raoni S. B., Wardell, James L., Wardell, Solange M. S. V., de Souza, Marcus V. N.

“…A series of 23 racemic mefloquine–oxazolidine derivatives, 4‐[3‐(aryl)hexahydro[1,3]oxazolo[3,4‐a]pyridin‐1‐yl]‐2,8‐bis(trifluoromethyl)quinolines, derived…”
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Mefloquine–oxazolidine derivatives, derived from mefloquine and arenecarbaldehydes: In vitro activity including against the multidrug-resistant tuberculosis strain T113 by Gonçalves, Raoni S.B., Kaiser, Carlos R., Lourenço, Maria C.S., Bezerra, Flavio A.F.M., de Souza, Marcus V.N., Wardell, James L., Wardell, Solange M.S.V., Henriques, Maria das Graças M.de O., Costa, Thadeu

“…Ten new mefloquine–oxazolidine derivatives, 4-[(1S,8aR)-3-(aryl)hexahydro[1,3]oxazolo[3,4-a]pyridin-1-yl]-2,8-bis(trifluoromethyl)quinoline (1:…”
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Synthesis, Antimalarial Activity, and Intracellular Targets of MEFAS, a New Hybrid Compound Derived from Mefloquine and Artesunate by DE PILLA VAROTTI, Fernando, BOTELHO, Ana Cristina C, URSINE KRETTII, Antoniana, ASSUNCAO ANDRADE, Anderson, DE PAULA, Renata C, FAGUNDES, Elaine M. S, VALVERDE, Alessandra, MAYER, Lucia M. U, SOUZA MENDONCA, Jorge, DE SOUZA, Marcus V. N, BOECHAT, Nubia

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Novel Organic Salts Based on Mefloquine: Synthesis, Solubility, Permeability, and In Vitro Activity against Mycobacterium tuberculosis by Silva, Dário, Lopes, Márcio V C, Petrovski, Željko, Santos, Miguel M, Santos, Jussevania P, Yamada-Ogatta, Sueli F, Bispo, Marcelle L F, de Souza, Marcus V N, Duarte, Ana Rita C, Lourenço, Maria C S, Gonçalves, Raoni Schroeder B, Branco, Luis C

“…The development of novel pharmaceutical tools to efficiently tackle tuberculosis is the order of the day due to the rapid development of resistant strains of …”
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Crystal structure of N‐(1,3‐benzothiazol‐2‐yl)‐4‐iodobenzene‐1‐sulfonohydrazide: the unexpected importance of l N‐H⋅⋅⋅π and I⋅⋅⋅π interactions on the supramolecular arrangement by Gomes, Lígia R., Früchtl, Herbert, Low, John N., Mourik, Tanja, Pinheiro, Alessandra C., Souza, Marcus V. N., Wardell, James L.

“…The 2‐hydrazinyl‐1,3‐benzothiazole derivatives are precursors for synthesis of several compounds of technological interest, including the Bt−NH−N=CHR1…”
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Three new platinum complexes containing fluoroquinolones and DMSO: Cytotoxicity and evaluation against drug-resistant tuberculosis by de Oliveira, Leticia P., Carneiro, Zumira A., Ribeiro, Camila M., Lima, Maurício F., Paixão, Drielly A., Pivatto, Marcos, de Souza, Marcus V.N., Teixeira, Letícia R., Lopes, Carla D., de Albuquerque, Sérgio, Pavan, Fernando R., Guerra, Wendell

“…This work describes the synthesis, characterization and biological evaluation of three platinum complexes of the type [Pt(DMSO)(L)Cl]Cl, in which L represents…”
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Synthesis and Biological Evaluation of Novel 1,3-Benzoxathiol-2-one Sulfonamides against Toxic Activities of the Venom of Bothrops jararaca and Bothrops jararacussu Snakes by Chazin, Eliza, Martins, Leonardo, de Souza, Marcus Vinícius, Gomes, Claudia Regina, da Silva, Ana Cláudia, Branco, Marcelly, Sanchez, Eladio, Fuly, André, Vasconcelos, Thatyana

“…This work describes the synthesis of new 1,3-benzoxathiol-2-one sulfonamides and evaluation of their ability to inhibit some in vitro (coagulant, proteolytic…”
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4H-1,3-Benzothiazin-4-one a Promising Class Against MDR/XDR-TB by de Souza, Marcus Vinicius Nora, Nogueira, Thais Cristina Mendonça

“…Nowadays, tuberculosis (TB) is an important global public health problem, being responsible for millions of TB-related deaths worldwide. Due to the increased…”
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