Distinct plasma chemokines and cytokines signatures in Leishmania guyanensis-infected patients with cutaneous leishmaniasis

The immunopathology associated with Leishmaniasis is a consequence of inflammation. Upon infection with Leishmania , the type of host-immune response is determinant for the clinical manifestations that can lead to either self-healing or chronic disease. Multiple pathways may determine disease severi...

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Published in:	Frontiers in immunology Vol. 13; p. 974051
Main Authors:	Mesquita, Tirza Gabrielle Ramos de, Junior, José do Espírito Santo, Silva, Luan Diego Oliveira da, Silva, George Allan Villarouco, Araújo, Felipe Jules de, Pinheiro, Suzana Kanawati, Kerr, Herllon Karllos Athaydes, Silva, Lener Santos da, Souza, Luciane Macedo de, Almeida, Samir Assad de, Queiroz, Krys Layane Guimarães Duarte, Souza, Josué Lacerda de, Silva, Cilana Chagas da, Sequera, Héctor David Graterol, Souza, Mara Lúcia Gomes de, Barbosa, Anderson Nogueira, Pontes, Gemilson Soares, Guerra, Marcus Vinitius de Farias, Ramasawmy, Rajendranath
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 25-08-2022
Subjects:	chemokines cutaneous leishmaniasis cytokines growth factors Immunology Leishmania guyanensis
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Summary:	The immunopathology associated with Leishmaniasis is a consequence of inflammation. Upon infection with Leishmania , the type of host-immune response is determinant for the clinical manifestations that can lead to either self-healing or chronic disease. Multiple pathways may determine disease severity. A comparison of systemic immune profiles in patients with cutaneous leishmaniasis caused by L. guyanensis and healthy individuals with the same socio-epidemiological characteristics coming from the same endemic areas as the patients is performed to identify particular immune profile and pathways associated with the progression of disease development. Twenty-seven plasma soluble circulating factors were evaluated between the groups by univariate and multivariate analysis. The following biomarkers pairs IL-17/IL-9 (ρ=0,829), IL-17/IL-12 (ρ=0,786), IL-6/IL-1ra (ρ=0,785), IL-6/IL-12 (ρ=0,780), IL-1β/G-CSF (ρ=0,758) and IL-17/MIP-1β (ρ=0,754) showed the highest correlation mean among the patient while only INF-γ/IL-4 (ρ=0.740), 17/MIP-1β (ρ=0,712) and IL-17/IL-9 (ρ=0,707) exhibited positive correlation among the control group. The cytokine IL-17 and IL1β presented the greater number of positive pair correlation among the patients. The linear combinations of biomarkers displayed IP-10, IL-2 and RANTES as the variables with the higher discriminatory activity in the patient group compared to PDGF, IL-1ra and eotaxin among the control subjects. IP-10, IL-2, IL-1β, RANTES and IL-17 seem to be predictive value of progression to the development of disease among the Lg -infected individuals.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Mohd Adnan, University of Hail, Saudi Arabia Reviewed by: Tatjana Keesen, Federal University of Paraíba, Brazil; Ahmad Khosravi, Kerman University of Medical Sciences, Iran This article was submitted to Parasite Immunology, a section of the journal Frontiers in Immunology
ISSN:	1664-3224 1664-3224
DOI:	10.3389/fimmu.2022.974051