Influence of exogenous opioids on the acute inflammatory response in the perioperative period of oncological surgery: a clinical study

Influence of exogenous opioids on the acute inflammatory response in the perioperative period of oncological surgery: a clinical study

Recently, opioids have been related to trigger changes in cytokine release and tumor angiogenesis processes, influencing tumor growth, metastasis, and recurrence. This is a prospective randomized clinical study to test whether if exogenous opioids used in the anesthesia during cancer surgery can aff...

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Bibliographic Details
Published in:Brazilian journal of anesthesiology (Elsevier) Vol. 74; no. 1; p. 744290
Main Authors: Titon, Odirlei Jo.·o, Titon, Joana Perotta, Silva, Jana.ína Carla da, Ferreira, Mariane Okamoto, Garbim, Matheus Ricrado, Rech, Daniel, Souza, Jano..rio Athanazio de, Panis, Carolina
Format: Journal Article
Language:English
Published: Brazil Elsevier España S.L.U 01-01-2024
Elsevier
Subjects:
Analgesics, Opioid
Anesthesia
Cancer
Cytokines
Female
Humans
Interleukin-12
Male
Neoplasms
Opioids
Original Investigation
Perioperative Period
Prospective Studies
Anesthesia
Cytokines
Opioids
Cancer
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Summary:Recently, opioids have been related to trigger changes in cytokine release and tumor angiogenesis processes, influencing tumor growth, metastasis, and recurrence. This is a prospective randomized clinical study to test whether if exogenous opioids used in the anesthesia during cancer surgery can affect the systemic inflammatory and immunological patterns. Patients were randomly allocated to the OP (opioid...inclusive) or OF (opioid-free) anesthesia group. A total of 45 patients were selected, being carriers of prostate, stomach, pancreas, bile ducts, breast, colon, lung, uterus, kidneys, or retroperitoneum tumors. Plasma levels of IL-4, IL-12, IL-17A, and TNF-.., and their oxidative stress profile before and after surgery were evaluated in both groups. In vitro tests were performed by using healthy donor blood incubated with each isolated drug used in patients... anesthesia for 1...hour, the same cytokines were measured in plasma. There was a significant reduction in lipid peroxidation in both groups. Patients from OF group had a significant consumption of IL-12 in the perioperative period. The other cytokines evaluated did not vary. It was also observed a significant correlation between IL-12 and TNF-.. levels in the OF-post group. Except for atracurium, all tested drugs led to a reduction in IL-12 levels. This study demonstrated that there is a reduction of IL-12 in the OF-post patients, suggesting acute consumption and that this seems to be a general mechanism of anesthetic drugs, as demonstrated in vitro. Also, these findings bring us to reflect if IL-12 changes may influence the disease progression and recurrence.
ISSN:0104-0014
0104-0014
2352-2291
DOI:10.1016/j.bjane.2021.09.011