Antimicrobial metabolites produced by endophytic fungi associated with the leaves of Vochysia divergens

Investigation of the endophytic fungi Nigrospora sphaerica, Nigrospora oryzae, and Pseudofusicoccum stromaticum MeOH fractions isolated from the leaves of Vochysia divergens, a medicinal species from the Brazilian Pantanal, led to the identification of five compounds, namely a new compound (1E,8Z)-1...

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Published in:	Natural product research Vol. 38; no. 6; pp. 978 - 985
Main Authors:	Souza, Jéssica A. de M., Gubiani, Juliana R., de Siqueira, Kátia A., de Camargo, Maria J., Garcez, Walmir S., de Sousa, Paulo T., Soares, Marcos A., Araújo, Ângela R., Nunes, Emanuel V. dos S., Vieira, Lucas C. C., Sampaio, Olívia M., Goulart, Letícia S., Biasetto, Carolina R., de Menezes, Orivaldo T., de Oliveira, Camila M., Nogueira, Cláudio R., Pinto, Luciano da S., Teles, Helder L.
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 18-03-2024 Taylor & Francis Ltd
Subjects:	antibacterial activity Antibacterial agents Antiinfectives and antibacterials Antimicrobial activity Divergence Endophytes Endophytic fungi Fungi Mass spectrometry Mass spectroscopy Metabolites Microorganisms Opportunist infection Vochysia divergens antibacterial activity Endophytic fungi Vochysia divergens
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Summary:	Investigation of the endophytic fungi Nigrospora sphaerica, Nigrospora oryzae, and Pseudofusicoccum stromaticum MeOH fractions isolated from the leaves of Vochysia divergens, a medicinal species from the Brazilian Pantanal, led to the identification of five compounds, namely a new compound (1E,8Z)-10,11-dihydroxy-5,5,8-trimethyl-4-oxocycloundeca-1,8-diene-1-carbaldehyde (1) and four known compounds: 5-methylmellein (2), sclerone (3), daldinone A (4), and lasiodiplodin (5). All compounds were identified using spectroscopic methods, and 1 was corroborated with mass spectrometry, while the known compounds were compared with data in the literature. The relative configuration of compound 1 was determined based on theoretical conformational studies as well as the J experimental values between the hydroxymethyne hydrogens. The antimicrobial activity of the compounds was evaluated. Promising results were obtained for compounds 2, 4, and 5 since they inhibited the bacterium Pseudomonas aeruginosa, an opportunistic pathogen, suggesting the potential of these microorganisms as a source of new antibacterial agents.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1478-6419 1478-6427
DOI:	10.1080/14786419.2023.2208723