Search Results - "Souza, Flavio S. J. de"

Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood by Nasif, Sofia, de Souza, Flavio S. J., González, Laura E., Yamashita, Miho, Orquera, Daniela P., Low, Malcolm J., Rubinstein, Marcelo

“…Food intake and body weight regulation depend on proper expression of the proopiomelanocortin gene (Pomc) in a group of neurons located in the mediobasal…”
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A Transgenic Marker for Newly Born Granule Cells in Dentate Gyrus by Overstreet, Linda S, Hentges, Shane T, Bumaschny, Viviana F, de Souza, Flavio S. J, Smart, James L, Santangelo, Andrea M, Low, Malcolm J, Westbrook, Gary L, Rubinstein, Marcelo

“…Neurogenesis in the dentate gyrus continues into adulthood, yet little is known about the function of newly born neurons or how they integrate into an existing…”
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Evolution of transcriptional enhancers and animal diversity by Rubinstein, Marcelo, de Souza, Flávio S. J.

“…Deciphering the genetic bases that drive animal diversity is one of the major challenges of modern biology. Although four decades ago it was proposed that…”
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Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold by Lam, Daniel D, de Souza, Flavio S J, Nasif, Sofia, Yamashita, Miho, López-Leal, Rodrigo, Otero-Corchon, Veronica, Meece, Kana, Sampath, Harini, Mercer, Aaron J, Wardlaw, Sharon L, Rubinstein, Marcelo, Low, Malcolm J

“…Cell-specific expression of many genes is conveyed by multiple enhancers, with each individual enhancer controlling a particular expression domain. In…”
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Convergent evolution of two mammalian neuronal enhancers by sequential exaptation of unrelated retroposons by Franchini, Lucía F, López-Leal, Rodrigo, Nasif, Sofía, Beati, Paula, Gelman, Diego M, Low, Malcolm J, de Souza, Flávio J. S, Rubinstein, Marcelo

“…The proopiomelanocortin gene (POMC) is expressed in a group of neurons present in the arcuate nucleus of the hypothalamus. Neuron-specific POMC expression in…”
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The Homeodomain Transcription Factor NKX2.1 Is Essential for the Early Specification of Melanocortin Neuron Identity and Activates Pomc Expression in the Developing Hypothalamus by Orquera, Daniela P, Tavella, M Belén, de Souza, Flavio S J, Nasif, Sofía, Low, Malcolm J, Rubinstein, Marcelo

“…Food intake is tightly regulated by a group of neurons present in the arcuate nucleus of the hypothalamus, which release -encoded melanocortins, the absence of…”
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Sequencing of small RNAs of the fern Pleopeltis minima (Polypodiaceae) offers insight into the evolution of the microrna repertoire in land plants by Berruezo, Florencia, de Souza, Flávio S J, Picca, Pablo I, Nemirovsky, Sergio I, Martínez Tosar, Leandro, Rivero, Mercedes, Mentaberry, Alejandro N, Zelada, Alicia M

“…MicroRNAs (miRNAs) are short, single stranded RNA molecules that regulate the stability and translation of messenger RNAs in diverse eukaryotic groups. Several…”
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Editorial: Transcription Regulation-Brain Development and Homeostasis-A Finely Tuned and Orchestrated Scenario in Physiology and Pathology by Muñoz, Estela M, de Souza, Flavio S J, Rath, Martin F, Martínez Cerdeño, Verónica

“…Editorial on the Research Topic Transcription Regulation—Brain Development and Homeostasis—A Finely Tuned and Orchestrated Scenario in Physiology and Pathology…”
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The estrogen receptor α colocalizes with proopiomelanocortin in hypothalamic neurons and binds to a conserved motif present in the neuron-specific enhancer nPE2 by de Souza, Flávio S.J., Nasif, Sofia, López-Leal, Rodrigo, Levi, Diego H., Low, Malcolm J., Rubinsten, Marcelo

“…The gene encoding the prohormone proopiomelanocortin (POMC) is mainly expressed in two regions in vertebrates, namely corticotrophs and melanotrophs in the…”
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Transcriptional Regulation of Pituitary POMC Is Conserved at the Vertebrate Extremes Despite Great Promoter Sequence Divergence by Bumaschny, Viviana F, de Souza, Flávio S. J, López Leal, Rodrigo A, Santangelo, Andrea M, Baetscher, Manfred, Levi, Diego H, Low, Malcolm J, Rubinstein, Marcelo

“…The stress response involves complex physiological mechanisms that maximize behavioral efficacy during attack or defense and is highly conserved in all…”
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Enhancer turnover and conserved regulatory function in vertebrate evolution by Domené, Sabina, Bumaschny, Viviana F., de Souza, Flávio S. J., Franchini, Lucía F., Nasif, Sofía, Low, Malcolm J., Rubinstein, Marcelo

“…Mutations in regulatory regions including enhancers are an important source of variation and innovation during evolution. Enhancers can evolve by changes in…”
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Ancient exaptation of a CORE-SINE retroposon into a highly conserved mammalian neuronal enhancer of the proopiomelanocortin gene by Santangelo, Andrea M, de Souza, Flávio S J, Franchini, Lucía F, Bumaschny, Viviana F, Low, Malcolm J, Rubinstein, Marcelo

“…The proopiomelanocortin gene (POMC) is expressed in the pituitary gland and the ventral hypothalamus of all jawed vertebrates, producing several bioactive…”
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A mammalian tripartite enhancer cluster controls hypothalamic Pomc expression, food intake, and body weight by Rojo, Daniela, Hael, Clara E, Soria, Agustina, de Souza, Flávio S J, Low, Malcolm J, Franchini, Lucía F, Rubinstein, Marcelo

“…Food intake and energy balance are tightly regulated by a group of hypothalamic arcuate neurons expressing the proopiomelanocortin ( gene. In mammals,…”
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Exaptation of transposable elements into novel cis-regulatory elements: is the evidence always strong? by de Souza, Flávio S J, Franchini, Lucía F, Rubinstein, Marcelo

“…Transposable elements (TEs) are mobile genetic sequences that can jump around the genome from one location to another, behaving as genomic parasites. TEs have…”
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Rathke's cleft-like cysts arise from Isl1 deletion in murine pituitary progenitors by Brinkmeier, Michelle L, Bando, Hironori, Camarano, Adriana C, Fujio, Shingo, Yoshimoto, Koji, de Souza, Flávio Sj, Camper, Sally A

“…The transcription factor ISL1 is expressed in pituitary gland stem cells and the thyrotrope and gonadotrope lineages. Pituitary-specific Isl1 deletion causes…”
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Conserved roles of Rax/rx3 genes in hypothalamus and pituitary development by De Souza, Flávio S J, Placzek, Marysia

“…( ) genes encode paired-type homeodomain-containing transcription factors present in virtually all metazoan groups. In vertebrates, studies in fish, amphibian,…”
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Obesity-programmed mice are rescued by early genetic intervention by Bumaschny, Viviana F, Yamashita, Miho, Casas-Cordero, Rodrigo, Otero-Corchón, Verónica, de Souza, Flávio S J, Rubinstein, Marcelo, Low, Malcolm J

“…Obesity is a chronic metabolic disorder affecting half a billion people worldwide. Major difficulties in managing obesity are the cessation of continued weight…”
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Essential function of the transcription factor Rax in the early patterning of the mammalian hypothalamus by Orquera, Daniela P., Nasif, Sofia, Low, Malcolm J., Rubinstein, Marcelo, de Souza, Flávio S.J.

“…The hypothalamus is a region of the anterior forebrain that controls basic aspects of vertebrate physiology, but the genes involved in its development are…”
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Identification of Neuronal Enhancers of the Proopiomelanocortin Gene by Transgenic Mouse Analysis and Phylogenetic Footprinting by de Souza, Flávio S. J., Santangelo, Andrea M., Bumaschny, Viviana, Avale, María Elena, Smart, James L., Low, Malcolm J., Rubinstein, Marcelo

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Selective pressure against horizontally acquired prokaryotic genes as a driving force of plastid evolution by Llorente, Briardo, de Souza, Flavio S. J., Soto, Gabriela, Meyer, Cristian, Alonso, Guillermo D., Flawiá, Mirtha M., Bravo-Almonacid, Fernando, Ayub, Nicolás D., Rodríguez-Concepción, Manuel

“…The plastid organelle comprises a high proportion of nucleus-encoded proteins that were acquired from different prokaryotic donors via independent horizontal…”
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