Search Results - "Souza, Flávio"

Rathke's cleft-like cysts arise from Isl1 deletion in murine pituitary progenitors by Brinkmeier, Michelle L, Bando, Hironori, Camarano, Adriana C, Fujio, Shingo, Yoshimoto, Koji, de Souza, Flávio Sj, Camper, Sally A

“…The transcription factor ISL1 is expressed in pituitary gland stem cells and the thyrotrope and gonadotrope lineages. Pituitary-specific Isl1 deletion causes…”
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Obesity-programmed mice are rescued by early genetic intervention by Bumaschny, Viviana F, Yamashita, Miho, Casas-Cordero, Rodrigo, Otero-Corchón, Verónica, de Souza, Flávio S J, Rubinstein, Marcelo, Low, Malcolm J

“…Obesity is a chronic metabolic disorder affecting half a billion people worldwide. Major difficulties in managing obesity are the cessation of continued weight…”
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Evolution of transcriptional enhancers and animal diversity by Rubinstein, Marcelo, de Souza, Flávio S. J.

“…Deciphering the genetic bases that drive animal diversity is one of the major challenges of modern biology. Although four decades ago it was proposed that…”
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Exaptation of transposable elements into novel cis-regulatory elements: is the evidence always strong? by de Souza, Flávio S J, Franchini, Lucía F, Rubinstein, Marcelo

“…Transposable elements (TEs) are mobile genetic sequences that can jump around the genome from one location to another, behaving as genomic parasites. TEs have…”
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The estrogen receptor α colocalizes with proopiomelanocortin in hypothalamic neurons and binds to a conserved motif present in the neuron-specific enhancer nPE2 by de Souza, Flávio S.J., Nasif, Sofia, López-Leal, Rodrigo, Levi, Diego H., Low, Malcolm J., Rubinsten, Marcelo

“…The gene encoding the prohormone proopiomelanocortin (POMC) is mainly expressed in two regions in vertebrates, namely corticotrophs and melanotrophs in the…”
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A mammalian tripartite enhancer cluster controls hypothalamic Pomc expression, food intake, and body weight by Rojo, Daniela, Hael, Clara E, Soria, Agustina, de Souza, Flávio S J, Low, Malcolm J, Franchini, Lucía F, Rubinstein, Marcelo

“…Food intake and energy balance are tightly regulated by a group of hypothalamic arcuate neurons expressing the proopiomelanocortin ( gene. In mammals,…”
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Convergent evolution of two mammalian neuronal enhancers by sequential exaptation of unrelated retroposons by Franchini, Lucía F, López-Leal, Rodrigo, Nasif, Sofía, Beati, Paula, Gelman, Diego M, Low, Malcolm J, de Souza, Flávio J. S, Rubinstein, Marcelo

“…The proopiomelanocortin gene (POMC) is expressed in a group of neurons present in the arcuate nucleus of the hypothalamus. Neuron-specific POMC expression in…”
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Essential function of the transcription factor Rax in the early patterning of the mammalian hypothalamus by Orquera, Daniela P., Nasif, Sofia, Low, Malcolm J., Rubinstein, Marcelo, de Souza, Flávio S.J.

“…The hypothalamus is a region of the anterior forebrain that controls basic aspects of vertebrate physiology, but the genes involved in its development are…”
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Sequencing of small RNAs of the fern Pleopeltis minima (Polypodiaceae) offers insight into the evolution of the microrna repertoire in land plants by Berruezo, Florencia, de Souza, Flávio S J, Picca, Pablo I, Nemirovsky, Sergio I, Martínez Tosar, Leandro, Rivero, Mercedes, Mentaberry, Alejandro N, Zelada, Alicia M

“…MicroRNAs (miRNAs) are short, single stranded RNA molecules that regulate the stability and translation of messenger RNAs in diverse eukaryotic groups. Several…”
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Conserved roles of Rax/rx3 genes in hypothalamus and pituitary development by De Souza, Flávio S J, Placzek, Marysia

“…( ) genes encode paired-type homeodomain-containing transcription factors present in virtually all metazoan groups. In vertebrates, studies in fish, amphibian,…”
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Enhancer turnover and conserved regulatory function in vertebrate evolution by Domené, Sabina, Bumaschny, Viviana F., de Souza, Flávio S. J., Franchini, Lucía F., Nasif, Sofía, Low, Malcolm J., Rubinstein, Marcelo

“…Mutations in regulatory regions including enhancers are an important source of variation and innovation during evolution. Enhancers can evolve by changes in…”
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Spray-drying wall materials: relationship with bioactive compounds by Coimbra, Pedro Paulo Saldanha, Cardoso, Flávio de Souza Neves, Gonçalves, Édira Castello Branco de Andrade

“…The encapsulation by spray drying is a common method of encapsulation on the food industry. Many biopolymers are described on the literature as wall materials…”
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Structure‐guided design combined with evolutionary diversity led to the discovery of the xylose‐releasing exo‐xylanase activity in the glycoside hydrolase family 43 by Zanphorlin, Letícia Maria, Morais, Mariana Abrahão Bueno, Diogo, José Alberto, Domingues, Mariane Noronha, Souza, Flávio Henrique Moreira, Ruller, Roberto, Murakami, Mario Tyago

“…Rational design is an important tool for sculpting functional and stability properties of proteins and its potential can be much magnified when combined with…”
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Brazilian varieties of acerola (Malpighia emarginata DC.) produced under tropical semi‐arid conditions: Bioactive phenolic compounds, sugars, organic acids, and antioxidant capacity by Carneiro Ferreira, Ianca, Pereira da Silva, Vagner, Vilvert, João Claudio, França Souza, Flávio, Freitas, Sérgio Tonetto, dos Santos Lima, Marcos

“…Acerola fruit has gained prominence for its high nutraceutical value, associated with high levels of ascorbic acid and phenolic compounds. The objectives of…”
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Sucralose causes non‐selective CD4 and CD8 lymphotoxicity via probable regulation of the MAPK8/APTX/EID1 genes: An in vitro/in silico study by Pasqualli, Thaís, Chaves, Pamella Eduardha, Pereira, Lavínia, Serpa, Élvio, Oliveira, Luís Flávio Souza, Machado, Michel Mansur

“…One of the most widely used sweeteners in the world is sucralose. With sweetening power 600 times greater than sucrose, its use grows among those who seek to…”
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A command to estimate and interpret models of dynamic compositional dependent variables: New features for dynsimpie by Jung, Yoo Sun, Souza, Flávio D. S., Philips, Andrew Q., Rutherford, Amanda, Whitten, Guy D.

“…Philips, Rutherford, and Whitten (2016, Stata Journal 16: 662–677) introduced dynsimpie, a command to examine dynamic compositional dependent variables. In…”
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Ancient exaptation of a CORE-SINE retroposon into a highly conserved mammalian neuronal enhancer of the proopiomelanocortin gene by Santangelo, Andrea M, de Souza, Flávio S J, Franchini, Lucía F, Bumaschny, Viviana F, Low, Malcolm J, Rubinstein, Marcelo

“…The proopiomelanocortin gene (POMC) is expressed in the pituitary gland and the ventral hypothalamus of all jawed vertebrates, producing several bioactive…”
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Musculoskeletal Disease in MDA5‐Related Type I Interferonopathy: A Mendelian Mimic of Jaccoud's Arthropathy by de Carvalho, Luciana Martins, Ngoumou, Gonza, Park, Ji Woo, Ehmke, Nadja, Deigendesch, Nikolaus, Kitabayashi, Naoki, Melki, Isabelle, Souza, Flávio Falcäo L., Tzschach, Andreas, Nogueira‐Barbosa, Marcello H., Ferriani, Virgínia, Louzada‐Junior, Paulo, Marques, Wilson, Lourenço, Charles M., Horn, Denise, Kallinich, Tilmann, Stenzel, Werner, Hur, Sun, Rice, Gillian I., Crow, Yanick J.

“…Objective To define the molecular basis of a multisystem phenotype with progressive musculoskeletal disease of the hands and feet, including camptodactyly,…”
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Neutrophil extracellular traps mediate joint hyperalgesia induced by immune inflammation by Schneider, Ayda Henriques, Machado, Caio Cavalcante, Veras, Flávio Protásio, Maganin, Alexandre Gomes de Macedo, de Souza, Flávio Falcão Lima, Barroso, Lívia Corrêa, de Oliveira, Renê Donizeti Ribeiro, Alves-Filho, José Carlos, Cunha, Thiago Mattar, Fukada, Sandra Yasuyo, Louzada-Júnior, Paulo, da Silva, Tarcília Aparecida, Cunha, Fernando Queiroz

“…Abstract Objective To evaluate the role of neutrophil extracellular traps (NETs) in the genesis of joint hyperalgesia using an experimental model of arthritis…”
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Are Media at Work in Your Neighborhood? The Effects of Media Freedom, Internet Access, and Information Spillover on Workers’ Rights by McKallagat, Christopher, Souza, Flávio D. S., Whitten-Woodring, Jenifer, Wimpy, Cameron

“…Objectives. In this study, we focus on how access to information empowers workers and pressures government and firms to improve labor conditions. Methods. We…”
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