Search Results - "Souza, Bruno Solano Freitas"

Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil by Nonaka, Carolina K V, Franco, Marília Miranda, Gräf, Tiago, de Lorenzo Barcia, Camila Araújo, de Ávila Mendonça, Renata Naves, de Sousa, Karoline Almeida Felix, Neiva, Leila M C, Fosenca, Vagner, Mendes, Ana V A, de Aguiar, Renato Santana, Giovanetti, Marta, de Freitas Souza, Bruno Solano

“…Uncertainty remains about how long the protective immune responses against severe acute respiratory syndrome coronavirus 2 persists, and suspected reinfection…”
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Early Transplantation of Bone Marrow Mononuclear Cells Promotes Neuroprotection and Modulation of Inflammation After Status Epilepticus in Mice by Paracrine Mechanisms by Leal, Marcos Maurício Tosta, Costa-Ferro, Zaquer Suzana Munhoz, Souza, Bruno Solano de Freitas, Azevedo, Carine Machado, Carvalho, Thiago Meneses, Kaneto, Carla Martins, Carvalho, Rejane Hughes, dos Santos, Ricardo Ribeiro, Soares, Milena Botelho Pereira

“…Status epilepticus (SE) is a severe clinical manifestation of epilepsy associated with intense neuronal loss and inflammation, two key factors involved in the…”
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Exercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesity by Improta Caria, Alex Cleber, Nonaka, Carolina Kymie Vasques, Pereira, Ciro Silveira, Soares, Milena Botelho Pereira, Macambira, Simone Garcia, Souza, Bruno Solano de Freitas

“…MicroRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally. They are involved in the regulation of physiological processes, such…”
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Exercise-Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes by Sousa, Ricardo Augusto Leoni De, Improta-Caria, Alex Cleber, Souza, Bruno Solano de Freitas

“…Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with insulin resistance and hyperglycemia. Chronic exposure to a T2DM microenvironment with…”
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Therapy with bone marrow cells reduces liver alterations in mice chronically infected by Schistosoma mansoni by Oliveira, Sheilla Andrade, Souza, Bruno-Solano-Freitas, Guimaraes-Ferreira, Carla-Adriana, Barreto, Elton-Sa, Souza, Siane-Campos, Freitas, Luiz-Antonio-Rodrigues, Ribeiro-Dos-Santos, Ricardo, Soares, Milena-Botelho-Pereira

“…AIM： To investigate the potential of bone marrow mononuclear cells （BM-MCs） in the regeneration of hepatic lesions induced by Schistosoma mansoni （S.mansoni）…”
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Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease by Improta-Caria, Alex Cleber, Nonaka, Carolina Kymie Vasques, Cavalcante, Bruno Raphael Ribeiro, De Sousa, Ricardo Augusto Leoni, Aras Júnior, Roque, Souza, Bruno Solano de Freitas

“…Alzheimer disease (AD) is one of the most common neurodegenerative diseases, affecting middle-aged and elderly individuals worldwide. AD pathophysiology…”
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SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, Northeast Brazil, February 2021 by Nonaka, Carolina Kymie Vasques, Gräf, Tiago, Barcia, Camila Araújo de Lorenzo, Costa, Vanessa Ferreira, de Oliveira, Janderson Lopes, Passos, Rogério da Hora, Bastos, Iasmin Nogueira, de Santana, Maria Clara Brito, Santos, Ian Marinho, de Sousa, Karoline Almeida Felix, Weber, Thamires Gomes Lopes, Siqueira, Isadora Cristina de, Rocha, Clarissa Araújo Gurgel, Mendes, Ana Verena Almeida, Souza, Bruno Solano de Freitas

“…•A second COVID-19 wave accelerated after the emergence of the P.1 lineage (Gamma).•An increased percentage of younger patients needed intensive care during…”
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Generation of an induced pluripotent stem cell line from a patient with epileptic encephalopathy caused by the CYFIP2 R87C variant by Silva, Isabelle Leticia Zaboroski, Gomes-Júnior, Rubens, da Silva, Evelin Brandão, Vaz, Isadora May, Jamur, Valderez Ravaglio, de Freitas Souza, Bruno Solano, Shigunov, Patrícia

“…Induced pluripotent stem cells (iPSCs) opened the possibility to use patient cells as a model for several diseases. iPSCs can be reprogrammed from somatic…”
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Circulating miRNAs as Potential Biomarkers Associated with Cardiac Remodeling and Fibrosis in Chagas Disease Cardiomyopathy by Nonaka, Carolina Kymie Vasques, Macêdo, Carolina Thé, Cavalcante, Bruno Raphael Ribeiro, Alcântara, Adriano Costa de, Silva, Daniela Nascimento, Bezerra, Milena da Rocha, Caria, Alex Cleber Improta, Tavora, Fábio Rocha Fernandes, Neto, João David de Souza, Noya-Rabelo, Márcia Maria, Rogatto, Silvia Regina, Ribeiro Dos Santos, Ricardo, Souza, Bruno Solano de Freitas, Soares, Milena Botelho Pereira

“…Chagas disease (CD) affects approximately 6-7 million people worldwide, from which 30% develop chronic Chagas cardiomyopathy (CCC), usually after being…”
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Effects of IGF-1 on Proliferation, Angiogenesis, Tumor Stem Cell Populations and Activation of AKT and Hedgehog Pathways in Oral Squamous Cell Carcinoma by Ferreira Mendes, Jéssica Mariane, de Faro Valverde, Ludmila, Torres Andion Vidal, Manuela, Paredes, Bruno Diaz, Coelho, Paulo, Allahdadi, Kyan James, Coletta, Ricardo Della, Souza, Bruno Solano de Freitas, Rocha, Clarissa Araújo Gurgel

“…(1) Background: Activation of the PI3K-AKT pathway controls most hallmarks of cancer, and the hedgehog (HH) pathway has been associated with oral squamous cell…”
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Therapeutic miR-21 Silencing Reduces Cardiac Fibrosis and Modulates Inflammatory Response in Chronic Chagas Disease by Nonaka, Carolina Kymie Vasques, Sampaio, Gabriela Louise, Silva, Katia Nunes, Khouri, Ricardo, Macedo, Carolina Thé, Chagas Translational Research Consortium, Rogatto, Silvia Regina, Ribeiro Dos Santos, Ricardo, Souza, Bruno Solano de Freitas, Soares, Milena Botelho Pereira

“…Chagas disease, caused by the parasite ( ), remains a serious public health problem for which there is no effective treatment in the chronic stage. Intense…”
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Association of Cardiac Galectin-3 Expression, Myocarditis, and Fibrosis in Chronic Chagas Disease Cardiomyopathy by de Freitas Souza, Bruno Solano, Silva, Daniela Nascimento, Carvalho, Rejane Hughes, de Almeida Sampaio, Gabriela Louise, Paredes, Bruno Diaz, Aragão França, Luciana, Azevedo, Carine Machado, Vasconcelos, Juliana Fraga, Meira, Cassio Santana, Neto, Paulo Chenaud, Macambira, Simone Garcia, da Silva, Kátia Nunes, Allahdadi, Kyan James, Tavora, Fabio, de Souza Neto, João David, dos Santos, Ricardo Ribeiro, Soares, Milena Botelho Pereira

“…Chronic Chagas disease cardiomyopathy, caused by Trypanosoma cruzi infection, is a major cause of heart failure in Latin America. Galectin-3 (Gal-3) has been…”
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IGF-1 overexpression improves mesenchymal stem cell survival and promotes neurological recovery after spinal cord injury by Allahdadi, Kyan James, de Santana, Thaís Alves, Santos, Girlaine Café, Azevedo, Carine Machado, Mota, Roberta Alves, Nonaka, Carolina Kymie, Silva, Daniela Nascimento, Valim, Clarissa Xavier Resende, Figueira, Cláudio Pereira, Dos Santos, Washington Luis Conrado, do Espirito Santo, Renan Fernandes, Evangelista, Afrânio Ferreira, Villarreal, Cristiane Flora, Dos Santos, Ricardo Ribeiro, de Souza, Bruno Solano Freitas, Soares, Milena Botelho Pereira

“…Survival and therapeutic actions of bone marrow-derived mesenchymal stem cells (BMMSCs) can be limited by the hostile microenvironment present during acute…”
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Advances in Hepatic Tissue Bioengineering with Decellularized Liver Bioscaffold by Souza, Bruno Solano de Freitas, Nonaka, Carolina Kymie, Quintanilha, Luiz Fernando, Rossi, Erik Aranha

“…The burden of liver diseases continues to grow worldwide, and liver transplantation is the only option for patients with end-stage liver disease. This…”
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MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise by Improta-Caria, Alex Cleber, De Sousa, Ricardo Augusto Leoni, Roever, Leonardo, Fernandes, Tiago, Oliveira, Edilamar Menezes de, Aras Júnior, Roque, Souza, Bruno Solano de Freitas

“…Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disease, and its prevalence has grown worldwide. Several pathophysiological processes contribute…”
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Early detection of P.1 variant of SARS-CoV-2 in a cluster of cases in Salvador, Brazil by de Siqueira, Isadora Cristina, Camelier, Aquiles Assunção, Maciel, Elves A.P., Nonaka, Carolina Kymie Vasques, Neves, Margarida Celia L.C., Macêdo, Yasmin Santos Freitas, de Sousa, Karoline Almeida Félix, Araujo, Victor Costa, Paste, Aurea Angelica, Souza, Bruno Solano de Freitas, Gräf, Tiago

“…•There is a cryptic transmission of the SARS-CoV-2 P.1 lineage across Brazil.•Genomic surveillance is important to track the emergence of SARS-CoV-2…”
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GANT61 Reduces Hedgehog Molecule (GLI1) Expression and Promotes Apoptosis in Metastatic Oral Squamous Cell Carcinoma Cells by Bacelar Sacramento de Araújo, Taís, de Oliveira Siquara da Rocha, Leonardo, Torres Andion Vidal, Manuela, Cerqueira Coelho, Paulo Lucas, Galvão Dos Reis, Mitermayer, Solano de Freitas Souza, Bruno, Botelho Pereira Soares, Milena, Almeida Pereira, Thiago, Della Coletta, Ricardo, Pereira Bezerra, Daniel, Borges Dias, Rosane, Araújo Gurgel Rocha, Clarissa

“…Due to its importance in the pathogenesis of oral squamous cell carcinoma (OSCC), the Hedgehog (HH) pathway is considered a potential therapeutic target. We…”
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Assessing the Clinical Impact of the SARS-CoV-2 Gamma Variant on Intensive Care Unit Admissions: Insights from a Reference Hospital in Northeastern Brazil by Nonaka, Carolina Kymie Vasques, de Jesus Ribeiro, Adlas Michel, Rocha, Gisele Vieira, da Hora, Helena Souza, Junior, Antônio Augusto Fonseca, Lima, Fernanda de Macêdo, Bastos, Iasmin Nogueira, Teles, Samara Alves Sa, Weber, Thamires Gomes Lopes, Costa, Vanessa Ferreira, Costa-Ferro, Zaquer Suzana, Rocha, Clarissa Araújo Gurgel, Sardi, Silvia Inês, Soares, Gúbio, Mendes, Ana Verena Almeida, Souza, Bruno Solano de Freitas

“…The global challenge posed by the prolonged COVID-19 pandemic underscores the critical need for ongoing genomic surveillance to identify emerging variants and…”
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Rapid Detection of SARS-CoV-2 Based on the LAMP Assay Associated with the CRISPRCas12a System by de Sousa, Karoline Almeida Felix, Nonaka, Carolina Kymie Vasques, Khouri, Ricardo, Gurgel Rocha, Clarissa Araújo, Regis-Silva, Carlos Gustavo, de Freitas Souza, Bruno Solano

“…The global public health system has been severely tested by the COVID-19 pandemic. Mass testing was essential in controlling the transmission of the…”
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The Presence and Extension of Myocardial Fibrosis in the Undetermined Form of Chagas' Disease: A Study Using Magnetic Resonance by Noya-Rabelo, Marcia Maria, Macedo, Carolina The, Larocca, Ticiana, Machado, Admilson, Pacheco, Thais, Torreão, Jorge, Souza, Bruno Solano de Freitas, Soares, Milena B P, Ribeiro-Dos-Santos, Ricardo, Correia, Luis Claudio Lemos

“…Previous data has shown that patients in the indeterminate form of Chagas disease may present myocardial fibrosis as shown on through magnetic resonance…”
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