Search Results - "Souza, Bárbara Kunzler"
-
1
Epidermal Growth Factor Receptor Regulation of Ewing Sarcoma Cell Function
Published in Oncology (01-01-2018)“…Ewing sarcoma (ES) is a type of childhood cancer probably arising from stem mesenchymal or neural crest cells. The epidermal growth factor receptor (EGFR) acts…”
Get more information
Journal Article -
2
Genomic analyses and transcriptional profiles of the glycoside hydrolase family 18 genes of the entomopathogenic fungus Metarhizium anisopliae
Published in PloS one (18-09-2014)“…Fungal chitin metabolism involves diverse processes such as metabolically active cell wall maintenance, basic nutrition, and different aspects of virulence…”
Get full text
Journal Article -
3
Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma
Published in Frontiers in pharmacology (26-06-2019)“…Neurotrophins are critically involved in regulating normal neural development and plasticity. Brain-derived neurotrophic factor (BDNF), a neurotrophin that…”
Get full text
Journal Article -
4
Trk inhibition reduces cell proliferation and potentiates the effects of chemotherapeutic agents in Ewing sarcoma
Published in Oncotarget (07-06-2016)“…Ewing sarcoma (ES) is a highly aggressive pediatric cancer that may arise from neuronal precursors. Neurotrophins stimulate neuronal devlopment and plasticity…”
Get full text
Journal Article -
5
Targeting Histone Deacetylase Activity to Arrest Cell Growth and Promote Neural Differentiation in Ewing Sarcoma
Published in Molecular neurobiology (01-09-2018)“…There is an urgent need for advances in the treatment of Ewing sarcoma (EWS), an aggressive childhood tumor with possible neuroectodermal origin. Inhibition of…”
Get full text
Journal Article -
6
Expression and pharmacological inhibition of TrkB and EGFR in glioblastoma
Published in Molecular biology reports (01-09-2020)“…A member of the Trk family of neurotrophin receptors, tropomyosin receptor kinase B (TrkB, encoded by the NTRK2 gene) is an increasingly important target in…”
Get full text
Journal Article -
7
Receptor Tyrosine Kinases as Candidate Prognostic Biomarkers and Therapeutic Targets in Meningioma
Published in International journal of molecular sciences (21-10-2021)“…Meningioma (MGM) is the most common type of intracranial tumor in adults. The validation of novel prognostic biomarkers to better inform tumor stratification…”
Get full text
Journal Article -
8
EHMT2/G9a as an Epigenetic Target in Pediatric and Adult Brain Tumors
Published in International journal of molecular sciences (19-10-2021)“…Epigenetic mechanisms, including post-translational modifications of DNA and histones that influence chromatin structure, regulate gene expression during…”
Get full text
Journal Article -
9
Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma
Published in International journal of molecular sciences (17-10-2023)“…Changes in epigenetic programming have been proposed as being key events in the initiation and progression of childhood cancers. HMT euchromatic histone lysine…”
Get full text
Journal Article -
10
Gastrin-Releasing Peptide Receptor Knockdown Induces Senescence in Glioblastoma Cells
Published in Molecular neurobiology (01-03-2017)“…Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor, characterized by excessive cell proliferation, resistance to apoptosis, and…”
Get full text
Journal Article -
11
Toll-like Receptors 2, 3, and 4 in Childhood Acute Lymphocytic Leukemia
Published in Revista Brasileira de Cancerologia (06-07-2023)“…Introduction: Acute lymphocytic leukemia (ALL) is the most common cancer type in children and accounts for 80% of pediatric leukemias. Novel targets are…”
Get full text
Journal Article -
12
Targeting histone deacetylase activity to arrest cell growth, reduce pluripotency, and promote differentiation in Ewing sarcoma
Published in Molecular neurobiology (03-02-2018)“…There is an urgent need for advances in the treatment of Ewing sarcoma (EWS), an aggressive childhood tumor with possible neuroectodermal or mesenchymal…”
Get full text
Journal Article -
13
Targeting the epigenome of cancer stem cells in pediatric nervous system tumors
Published in Molecular and cellular biochemistry (01-10-2023)“…Medulloblastoma, neuroblastoma, and pediatric glioma account for almost 30% of all cases of pediatric cancers. Recent evidence indicates that pediatric nervous…”
Get full text
Journal Article -
14
Histone Methyltransferases G9a/IEhmt2/I and GLP/IEhmt1/I Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma
Published in International journal of molecular sciences (01-10-2023)“…Changes in epigenetic programming have been proposed as being key events in the initiation and progression of childhood cancers. HMT euchromatic histone lysine…”
Get full text
Journal Article -
15
G9a/EHMT2 is a Potential Prognostic Biomarker and Molecular Target in SHH Medulloblastoma
Published in Neuromolecular medicine (01-12-2022)“…Changes in epigenetic programming are associated with cancer development during childhood. Components of the epigenetic machinery involved in normal embryonic…”
Get full text
Journal Article -
16
Genomic Analyses and Transcriptional Profiles of the Glycoside Hydrolase Family 18 Genes of the Entomopathogenic Fungus Metarhizium anisopliae: e107864
Published in PloS one (01-09-2014)“…Fungal chitin metabolism involves diverse processes such as metabolically active cell wall maintenance, basic nutrition, and different aspects of virulence…”
Get full text
Journal Article