Basal cortisol levels and the relationship with clinical symptoms in multiple sclerosis: a systematic review

ABSTRACT Multiple sclerosis (MS) is a demyelinating, progressive and neurodegenerative disease. A disturbance on the hypothalamic-pituitary-adrenal axis can be observed in patients with MS, showing altered cortisol levels. We aimed to identify basal cortisol levels and verify the relationship with c...

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Published in:	Arquivos de neuro-psiquiatria Vol. 76; no. 9; pp. 622 - 634
Main Authors:	Pereira, Gabriela Magalhães, Soares, Nayron Medeiros, Souza, Andreo Rysdyk de, Becker, Jefferson, Finkelsztejn, Alessandro, Almeida, Rosa Maria Martins de
Format:	Journal Article
Language:	English
Published:	Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil Thieme Revinter Publicações Ltda 01-09-2018 Arquivos de Neuro-Psiquiatria Academia Brasileira de Neurologia - ABNEURO Academia Brasileira de Neurologia (ABNEURO)
Subjects:	Adrenal glands Anxiety Cortisol Demyelination Disease Progression Fatigue general symptoms Hair - chemistry Hormones Humans hydrocortisone Hydrocortisone - analysis Hydrocortisone - blood Hydrocortisone - urine Hypothalamic-pituitary-adrenal axis Hypothalamus Mental depression Multiple sclerosis Multiple Sclerosis - diagnosis Multiple Sclerosis - psychology neurologic manifestations NEUROSCIENCES Pituitary pituitary-adrenal system PSYCHIATRY Saliva - chemistry Stress, Psychological Symptom Assessment View and Review hidrocortisona Multiple sclerosis sistema hipófise-suprarrenal general symptoms hydrocortisone Esclerose múltipla neurologic manifestations manifestações neurológicas sintomas gerais pituitary-adrenal system
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Summary:	ABSTRACT Multiple sclerosis (MS) is a demyelinating, progressive and neurodegenerative disease. A disturbance on the hypothalamic-pituitary-adrenal axis can be observed in patients with MS, showing altered cortisol levels. We aimed to identify basal cortisol levels and verify the relationship with clinical symptoms in patients with MS. A systematic search was conducted in the databases: Pubmed, Web of Science and SCOPUS. Both higher and lower cortisol levels were associated with MS. Higher cortisol levels were associated with depression and anxiety, while lower levels were associated with depression, fatigue and urinary dysfunction. Higher cortisol levels may be associated with the progression and severity of MS.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	0004-282X 1678-4227 1678-4227
DOI:	10.1590/0004-282X20180091