Evaluation of follicular flushing with double lumen needle in patients undergoing assisted reproductive technology treatments

Evaluation of follicular flushing with double lumen needle in patients undergoing assisted reproductive technology treatments

The purpose of this study was to investigate the possible impact of follicular flushing on the number of oocytes retrieved and oocytes in metaphase II in patients with poor ovarian response (POR) compared to direct aspiration. This prospective, comparative, randomized single center study included 20...

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Published in:JBRA assisted reproduction Vol. 25; no. 2; pp. 272 - 275
Main Authors: Souza, Marcelo Marinho de, Mancebo, Ana Cristina Allemand, Souza, Maria do Carmo Borges de, Antunes, Roberto de Azevedo, Barbeitas, Ana Luiza, Raupp, Verônica de Almeida, Silva, Layna Almeida Barbosa da, Siqueira, Flávia, Souza, Ana Luisa Bruno Marinho de
Format: Journal Article
Language:English
Published: Brazil Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction) 2021
Brazilian Society of Assisted Reproduction
Subjects:
Female
Fertilization in Vitro
Humans
In vitro fertilization
Needles
Oocyte Retrieval
Oocytes
Original
Ovaries
Patients
Performance evaluation
Pregnancy
Pregnancy Rate
Prospective Studies
Reproductive Techniques, Assisted
Reproductive technologies
Statistical analysis
Ultrasonic imaging
Vagina
Switzerland
in vitro fertilization
ovarian follicle
instrumentation
oocyte retrieval
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Summary:The purpose of this study was to investigate the possible impact of follicular flushing on the number of oocytes retrieved and oocytes in metaphase II in patients with poor ovarian response (POR) compared to direct aspiration. This prospective, comparative, randomized single center study included 208 punctures of patients with POR, submitted to assisted reproduction technology (ART) treatments. Two groups were compared; one in which double lumen needles were used (Wallace DNS1733) for follicular flushing (n=105), and one in which single lumen needles were used (Wallace ONS1733) for direct aspiration (n=103), upon the observation of ≤ 5 follicles between 15-17 mm, ≤ 4 follicles with sizes greater than 18 mm on hCG day, and ≤ 7 recovered oocytes. There were no differences in age (39.07±3.88 vs. 38.11±3.43); weight (61.73±17.53 vs. 65.96±15.44); AMH (0.63±0.59 vs. 0.94±0.97); stimulation days (9.57±1.87 vs. 10.29±2.82); estradiol levels (788.94±670.82 vs. 940.16±694.69); progesterone (617.29±319.76 vs. 561.18±486.78); or number of follicles with sizes ≥18 mm (1.84±0.95 vs. 2.07±1.09). Although gonadotropin totals (1678.28±798.52 vs. 2080.45±852.36; p=0.0008), number of aspirated oocytes (3.00±2.11 vs. 3.69±2.20; p=0.02), and number of metaphase II oocytes (2.20±1.64 vs. 2.99±1.88; p=0.02) were significantly different, oocyte / follicle ratio ≥15 mm (0.93 vs. 0.98) and metaphase II oocytes / follicles ≥15 mm (0.68 vs. 0.79) were similar in both groups. The failure to capture was 16% vs. 9.8%. Considering that there was no difference in the oocyte per follicle ratio, follicular flushing did not increase the number of oocytes recovered from poor responders.
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ISSN:1518-0557
1517-5693
1518-0557
DOI:10.5935/1518-0557.20210009