The role of antibiotic prophylaxis on wound infection after mesh hernia repair under local anesthesia on an ambulatory basis

Mesh prosthesis, local anesthesia, and ambulatory care have been widely introduced in recent decades in the treatment of inguinal hernia. The use of antibiotic prophylaxis during open inguinal hernia repair has been controversial. No prospective trial has been conducted to assess the role of antibio...

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Bibliographic Details
Published in:	Hernia : the journal of hernias and abdominal wall surgery Vol. 8; no. 1; pp. 20 - 22
Main Authors:	Celdrán, Angel, Frieyro, Octavio, de la Pinta, Juan C, Souto, José L, Esteban, Jaime, Rubio, José M, Señarís, José F
Format:	Journal Article
Language:	English
Published:	France Springer Nature B.V 01-02-2004
Subjects:	Aged Ambulatory Surgical Procedures Anesthesia, Local Anti-Bacterial Agents - therapeutic use Antibiotic Prophylaxis Cefazolin - therapeutic use Double-Blind Method Female Hernia, Inguinal - surgery Humans Male Middle Aged Prospective Studies Prostheses and Implants Surgical Mesh Surgical Wound Infection - prevention & control
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Summary:	Mesh prosthesis, local anesthesia, and ambulatory care have been widely introduced in recent decades in the treatment of inguinal hernia. The use of antibiotic prophylaxis during open inguinal hernia repair has been controversial. No prospective trial has been conducted to assess the role of antibiotic prophylaxis in patients operated on for inguinal hernia under the above-mentioned conditions. A prospective, randomized, double-blinded trial was initiated to assess the efficacy of antibiotic prophylaxis in the prevention of wound infection during open mesh inguinal hernia repair under local anesthesia on an ambulatory basis. Ninety-nine consecutive hernia repairs were randomized to receive 1 g of parenteral Cefazolin preoperatively or a placebo. No wound infections existed in the therapeutic group (0/50). Four infections appeared in the control group (4/49), and the study was suspended for ethical reasons when differences reached values close to statistical significance ( P=0.059). We conclude that a single dose of intravenous Cefazolin decreases the risk of wound infection during open mesh inguinal hernia repair under local anesthesia on an ambulatory basis.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23
ISSN:	1265-4906 1248-9204
DOI:	10.1007/s10029-003-0164-7