Search Results - "Southey, Bruce"
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Characterization of the prohormone complement in Amphiprion and related fish species integrating genome and transcriptome assemblies
Published in PloS one (12-03-2020)“…The Amphiprion (anemonefish or clownfish) family of teleost fish, which is not a common model species, exhibits multiple unique characteristics, including…”
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Brain region-dependent gene networks associated with selective breeding for increased voluntary wheel-running behavior
Published in PloS one (02-08-2018)“…Mouse lines selectively bred for high voluntary wheel-running behavior are helpful models for uncovering gene networks associated with increased motivation for…”
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3
Bioinformatics for Prohormone and Neuropeptide Discovery
Published in Methods in molecular biology (Clifton, N.J.) (2024)“…Neuropeptides and peptide hormones are signaling molecules produced via complex posttranslational modifications of precursor proteins known as prohormones…”
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Microglia Transcriptome Changes in a Model of Depressive Behavior after Immune Challenge
Published in PloS one (09-03-2016)“…Depression symptoms following immune response to a challenge have been reported after the recovery from sickness. A RNA-Seq study of the dysregulation of the…”
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Seasonal adaptations of the hypothalamo-neurohypophyseal system of the dromedary camel
Published in PloS one (18-06-2019)“…The "ship" of the Arabian and North African deserts, the one-humped dromedary camel (Camelus dromedarius) has a remarkable capacity to survive in conditions of…”
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Honey bee aggression supports a link between gene regulation and behavioral evolution
Published in Proceedings of the National Academy of Sciences - PNAS (08-09-2009)“…A prominent theory states that animal phenotypes arise by evolutionary changes in gene regulation, but the extent to which this theory holds true for…”
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Cerebellum Transcriptome of Mice Bred for High Voluntary Activity Offers Insights into Locomotor Control and Reward-Dependent Behaviors
Published in PloS one (28-11-2016)“…The role of the cerebellum in motivation and addictive behaviors is less understood than that in control and coordination of movements. High running can be a…”
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Epigenetic disruptions in the offspring hypothalamus in response to maternal infection
Published in Gene (05-06-2024)“…•DNA methylation varies across developmental stages, inflammatory conditions, and sexes.•This study provides insights into the impact of viral infection during…”
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Opioid-Induced Hyperalgesia Is Associated with Dysregulation of Circadian Rhythm and Adaptive Immune Pathways in the Mouse Trigeminal Ganglia and Nucleus Accumbens
Published in Molecular neurobiology (01-12-2019)“…The benefits of opioid-based treatments to mitigate chronic pain can be hindered by the side effects of opioid-induced hyperalgesia (OIH) that can lead to…”
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10
Comparative Analysis of Neuropeptides in Homologous Interneurons and Prohormone Annotation in Nudipleuran Sea Slugs
Published in Frontiers in physiology (23-12-2021)“…Despite substantial research on neuronal circuits in nudipleuran gastropods, few peptides have been implicated in nudipleuran behavior. In this study, we…”
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Hippocampal Changes Elicited by Metabolic and Inflammatory Stressors following Prenatal Maternal Infection
Published in Genes (26-12-2022)“…The hippocampus participates in spatial navigation and behavioral processes, displays molecular plasticity in response to environmental challenges, and can…”
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Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival
Published in BMC medical genomics (07-06-2011)“…Glioblastoma is a complex multifactorial disorder that has swift and devastating consequences. Few genes have been consistently identified as prognostic…”
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Lasting and Sex-Dependent Impact of Maternal Immune Activation on Molecular Pathways of the Amygdala
Published in Frontiers in neuroscience (11-08-2020)“…The prolonged and sex-dependent impact of maternal immune activation (MIA) during gestation on the molecular pathways of the amygdala, a brain region that…”
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Peptide identifications and false discovery rates using different mass spectrometry platforms
Published in Talanta (Oxford) (15-05-2018)“…Characterization of endogenous neuropeptides produced from post-translational proteolytic processing of precursor proteins is a demanding task. A variety of…”
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Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms
Published in Psychoneuroendocrinology (01-11-2018)“…•IDO1 deficiency is associated with changes in the abundance of 14-3-3 (YWHA) proteins that belong to the tryptophan pathway.•Proteins associated with BCG…”
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Differential Transcriptome Networks between IDO1-Knockout and Wild-Type Mice in Brain Microglia and Macrophages
Published in PloS one (01-06-2016)“…Microglia in the brain and macrophages in peripheral organs are cell types responsible for immune response to challenges. Indoleamine 2,3-dioxygenase 1 (IDO1)…”
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Genes Participating in the Ensheathment of Neurons Are Affected by Postnatal Stress and Maternal Immune Activation in the Pituitary Gland
Published in Genes (28-04-2023)“…Immune challenges during gestation are associated with neurodevelopmental disorders and can interact with stress later in life. The pituitary gland…”
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Alternative Splicing of Neuropeptide Prohormone and Receptor Genes Associated with Pain Sensitivity Was Detected with Zero-Inflated Models
Published in Biomedicines (10-04-2022)“…Migraine is often accompanied by exacerbated sensitivity to stimuli and pain associated with alternative splicing of genes in signaling pathways. Complementary…”
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Characterization of Genomic Variants Associated with Scout and Recruit Behavioral Castes in Honey Bees Using Whole-Genome Sequencing
Published in PloS one (19-01-2016)“…Among forager honey bees, scouts seek new resources and return to the colony, enlisting recruits to collect these resources. Differentially expressed genes…”
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Ancient grains as novel dietary carbohydrate sources in canine diets
Published in Journal of animal science (01-06-2021)“…Abstract Ancient grains are becoming an increasingly abundant carbohydrate source in the pet food market as a result of their popularity and novelty in the…”
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