Search Results - "Sousuke KANAYA"

Wnt5a signaling is a substantial constituent in bone morphogenetic protein-2-mediated osteoblastogenesis by Nemoto, Eiji, Ebe, Yukari, Kanaya, Sousuke, Tsuchiya, Masahiro, Nakamura, Takashi, Tamura, Masato, Shimauchi, Hidetoshi

“…► Wnt5a is identified in osteoblasts in tibial growth plate and bone marrow. ► Osteoblastic differentiation is associated with increased expression of…”
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Elevated extracellular calcium increases expression of bone morphogenetic protein-2 gene via a calcium channel and ERK pathway in human dental pulp cells by Tada, Hiroyuki, Nemoto, Eiji, Kanaya, Sousuke, Hamaji, Nozomu, Sato, Hisae, Shimauchi, Hidetoshi

“…Dental pulp cells, which have been shown to share phenotypical features with osteoblasts, are capable of differentiating into odontoblast-like cells and…”
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Extracellular calcium increases fibroblast growth factor 2 gene expression via extracellular signal-regulated kinase 1/2 and protein kinase A signaling in mouse dental papilla cells by Kanaya, Sousuke, Xiao, Binlu, Sakisaka, Yukihiko, Suto, Mizuki, Maruyama, Kentaro, Saito, Masahiro, Nemoto, Eiji

“…We previously reported that elevated extracellular calcium (Ca2+) levels increase bone morphogenetic protein 2 expression in human dental pulp (hDP) cells…”
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Metabotropic glutamate receptor 1 promotes cementoblast proliferation via MAP kinase signaling pathways by Kanaya, Sousuke, Komatsu, Hidehiro, Shimauchi, Hidetoshi, Nemoto, Eiji

“…Glutamate is one of the signaling molecules responsible for transmission in the central nervous system. Periodontal ligament (PDL) cells were recently reported…”
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Nanohydroxyapatite increases BMP-2 expression via a p38 MAP kinase dependent pathway in periodontal ligament cells by Suto, Mizuki, Nemoto, Eiji, Kanaya, Sousuke, Suzuki, Risako, Tsuchiya, Masahiro, Shimauchi, Hidetoshi

“…Abstract Objective Bone morphogenetic protein (BMP)-2 promotes the osteoblastic differentiation of human periodontal ligament (PDL) cells, which play a pivotal…”
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Elevated extracellular calcium increases fibroblast growth factor-2 gene and protein expression levels via a cAMP/PKA dependent pathway in cementoblasts by Kanaya, Sousuke, Nemoto, Eiji, Ebe, Yukari, Somerman, Martha J, Shimauchi, Hidetoshi

“…Abstract Cementoblasts, tooth root lining cells, are responsible for laying down cementum on the root surface, a process that is indispensable for establishing…”
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Extracellular β-NAD(+) inhibits interleukin-1-induced matrix metalloproteinase-1 and -3 expression on human gingival fibroblasts by Gotoh, Kazuhiro, Nemoto, Eiji, Kanaya, Sousuke, Shimauchi, Hidetoshi

“…There is increasing evidence to show that extracellular β-nicotinamide adenine dinucleotide (β-NAD(+)) modulates various biological functions in…”
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Proliferation of Periodontal Ligament Cells on Biodegradable Honeycomb Film Scaffold with Unified Micropore Organization by Hiroshi ISHIHATA, Masaru TANAKA, Nagayoshi IWAMA, Masahiro ARA, Mitsuru SHIMONISHI, Masaru NAGAMINE, Noriaki MURAKAMI, Sousuke KANAYA, Eiji NEMOTO, Hidetoshi SHIMAUCHI, Masatsugu SHIMOMURA

“…Tissue-engineered grafts using a scaffold can be used in treating periodontal disease; however, previous scaffolds for the cultivations of the periodontal…”
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Retinoic acid is a potential negative regulator for differentiation of human periodontal ligament cells by Shibuya, Natsuko, Nemoto, Eiji, Kanaya, Sousuke, Kunii, Ryotaro, Shimauchi, Hidetoshi

“…Background and objectives:  Retinoic acid (RA) exerts a wide variety of effects on development, cellular differentiation and homeostasis in various tissues…”
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Calcium-mediated increased expression of fibroblast growth factor-2 acts through NF-κB and PGE2 /EP4 receptor signaling pathways in cementoblasts by Kanaya, Sousuke, Nemoto, Eiji, Sakisaka, Yukihiko, Shimauchi, Hidetoshi

“…Abstract We reported previously that cementoblasts are provided with sensing mechanisms for extracellular Ca 2 + and that elevated extracellular Ca 2 +…”
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Calcium Phosphate Particles Induce Interleukin‐8 Expression in a Human Gingival Epithelial Cell Line via the Nuclear Factor‐κB Signaling Pathway by Sakai, Yu, Nemoto, Eiji, Kanaya, Sousuke, Shimonishi, Mitsuru, Shimauchi, Hidetoshi

“…Background: Dental calculus is calcified plaque composed primarily of calcium phosphate mineral salts, and there is a clear association between the presence of…”
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Wnt signaling inhibits cementoblast differentiation and promotes proliferation by Nemoto, Eiji, Koshikawa, Yohei, Kanaya, Sousuke, Tsuchiya, Masahiro, Tamura, Masato, Somerman, Martha J, Shimauchi, Hidetoshi

“…Abstract Cementoblasts, tooth root lining cells, are responsible for laying down cementum on the root surface, a process that is indispensable for establishing…”
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p38 MAP kinase is required for Wnt3a-mediated osterix expression independently of Wnt-LRP5/6-GSK3β signaling axis in dental follicle cells by Sakisaka, Yukihiko, Kanaya, Sousuke, Nakamura, Takashi, Tamura, Masato, Shimauchi, Hidetoshi, Nemoto, Eiji

“…Wnt3a is a secreted glycoprotein that activates the glycogen synthase kinase-3β (GSK3β)/β-catenin signaling pathway through low-density-lipoprotein…”
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Porphyromonas gingivalis lipopolysaccharides induce maturation of dendritic cells with CD14+CD16+ phenotype by Kanaya, Sousuke, Nemoto, Eiji, Ogawa, Tomohiko, Shimauchi, Hidetoshi

“…Primary immune responses are initiated by dendritic cells (DC) that inform naive T helper cells about invading pathogens. DC undergo sequential events leading…”
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Porphyromonas gingivalis lipopolysaccharides induce maturation of dendritic cells with CD14 super(+)CD16 super(+) phenotype by Kanaya, Sousuke, Nemoto, Eiji, Ogawa, Tomohiko, Shimauchi, Hidetoshi

“…Primary immune responses are initiated by dendritic cells (DC) that inform naive T helper cells about invading pathogens. DC undergo sequential events leading…”
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Expression of CD13/aminopeptidase N on human gingival fibroblasts and up-regulation upon stimulation with interleukin-4 and interleukin-13 by Kunii, Ryotaro, Nemoto, Eiji, Kanaya, Sousuke, Tsubahara, Taisuke, Shimauchi, Hidetoshi

“…Background and objectives:  Aminopeptidase N (APN)/CD13 is a multifunctional ectoenzyme that is involved in anti‐inflammatory reactions, control of immune…”
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Retinoic acid is a potential negative regulator for differentiation of human periodontal ligament cells by Shibuya, Natsuko, Nemoto, Eiji, Kanaya, Sousuke, Kunii, Ryotaro, Shimauchi, Hidetoshi

“…Retinoic acid (RA) exerts a wide variety of effects on development, cellular differentiation and homeostasis in various tissues. However, little is known about…”
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