Search Results - "Soussi, T."

p53 alterations in human cancer: more questions than answers by Soussi, T

“…The strongest and undisputed fact about p53 is the high frequency of p53 alterations in human cancer and that mutant p53 proteins constitute a complex family…”
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TP53: an oncogene in disguise by Soussi, T, Wiman, K G

“…The standard classification used to define the various cancer genes confines tumor protein p53 (TP53) to the role of a tumor suppressor gene. However, it is…”
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p53 mutation heterogeneity in cancer by Soussi, T., Lozano, G.

“…The p53 gene is inactivated in about 50% of human cancers and the p53 protein is an essential component of the cell response induced by genotoxic stresses such…”
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ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—update on methodological approaches and results interpretation by Malcikova, J., Tausch, E., Rossi, D., Sutton, L. A., Soussi, T., Zenz, T., Kater, A. P., Niemann, C. U., Gonzalez, D., Davi, F., Gonzalez Diaz, M., Moreno, C., Gaidano, G., Stamatopoulos, K., Rosenquist, R., Stilgenbauer, S., Ghia, P., Pospisilova, S.

“…In chronic lymphocytic leukemia (CLL), TP53 gene defects, due to deletion of the 17p13 locus and/or mutation(s) within the TP53 gene, are associated with…”
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The p53 pathway and human cancer by Soussi, T.

“…What we have learned since 1989…”
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MDM2-TP53 Crossregulation: An Underestimated Target to Promote Loss of TP53 Function and Cell Survival by Soussi, T, Kroemer, G

“…Half of human cancers bear inactivating mutations of the tumor suppressor gene TP53, but the other half do not. In a recent issue of Cancer Cell, Dhar et al…”
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TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations by Zenz, T, Vollmer, D, Trbusek, M, Smardova, J, Benner, A, Soussi, T, Helfrich, H, Heuberger, M, Hoth, P, Fuge, M, Denzel, T, Häbe, S, Malcikova, J, Kuglik, P, Truong, S, Patten, N, Wu, L, Oscier, D, Ibbotson, R, Gardiner, A, Tracy, I, Lin, K, Pettitt, A, Pospisilova, S, Mayer, J, Hallek, M, Döhner, H, Stilgenbauer, S

“…The TP53 mutation profile in chronic lymphocytic leukemia (CLL) and the correlation of TP53 mutations with allele status or associated molecular genetics are…”
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Mutations in TP53 are exclusively associated with del(17p) in multiple myeloma by LODE, Laurence, EVEILLARD, Marion, GUILHOT, François, CAILLOT, Denis, MARIT, Gérald, MATHIOT, Claire, FACON, Thierry, ATTAL, Michel, HAROUSSEAU, Jean-Luc, MOREAU, Philippe, MINVIELLE, Stéphane, AVET-LOISEAU, Hervé, TRICHET, Valérie, SOUSSI, Thierry, WUILLEME, Soraya, RICHEBOURG, Steven, MAGRANGEAS, Florence, IFRAH, Norbert, CAMPION, Loic, TRAULLE, Catherine

“…Deletion of the 17p13 chromosomal region [del(17p)] is associated with a poor outcome in multiple myeloma. Most of the studies have targeted the TP53 gene for…”
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Genetic profiling of CLL: a ‘TP53 addict’ perspective by Lodé, L, Cymbalista, F, Soussi, T

“…Chronic lymphocytic leukaemia (CLL) is a B-cell malignancy with a highly variable clinical course. Whereas some patients require treatment relatively soon…”
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Locus-specific mutation databases: pitfalls and good practice based on the p53 experience by Soussi, Thierry, Ishioka, Chikashi, Claustres, Mireille, Béroud, Christophe

“…Between 50,000 and 60,000 mutations have been described in various genes that are associated with a wide variety of diseases. Reporting, storing and analysing…”
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The UMD TP53 database and website: update and revisions by Hamroun, Dalil, Kato, Shunsuke, Ishioka, Chikashi, Claustres, Mireille, Béroud, Christophe, Soussi, Thierry

“…Mutation of the p53 gene is the most frequent genetic alteration found in human cancer, but it is also the most frequently reported with more than 22,000…”
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Structural Aspects of the p53 Protein in Relation to Gene Evolution: A Second Look by Soussi, Thierry, May, Pierre

“…Several years ago, a comparison of the amino acid sequences of p53 proteins from a variety of species enabled us to reveal structural features of this protein,…”
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Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects by Hainaut, P., Soussi, T., Shomer, B., Hollstein, M., Greenblatt, M., Hovig, E., Harris, C. C., Montesano, R.

“…In recent years, there has been an exponential increase in the number of p53 mutations identified in human cancers. The p53 mutation database consists of a…”
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Meta-analysis of the p53 Mutation Database for Mutant p53 Biological Activity Reveals a Methodologic Bias in Mutation Detection by SOUSSI, Thierry, ASSELAIN, Bernard, HAMROUN, Dalil, KATO, Shunsuke, ISHIOKA, Chikashi, CLAUSTRES, Mireille, BEROUD, Christophe

“…Purpose: Analyses of the pattern of p53 mutations have been essential for epidemiologic studies linking carcinogen exposure and cancer. We were concerned by…”
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Somatic Point Mutations in the p53 Gene of Human Tumors and Cell Lines: Updated Compilation by Hollstein, M., Shomer, B., Greenblatt, M., Soussi, T., Hovig, E., Montesano, R., Harris, C.C.

“…In 1994 we described a list of ∼2500 point mutations in the p53 gene of human tumors and cell lines which we had compiled from the published literature and…”
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Multifactorial analysis of p53 alteration in human cancer: a review by Soussi, T, Legros, Y, Lubin, R, Ory, K, Schlichtholz, B

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Database of p53 gene somatic mutations in human tumors and cell lines by Hollstein, M, Rice, K, Greenblatt, M S, Soussi, T, Fuchs, R, Sørlie, T, Hovig, E, Smith-Sørensen, B, Montesano, R, Harris, C C

“…A data base is described in which over 2,500 mutations in the p53 gene of human tumors and tumor cell lines are compiled from a systematic search of reports…”
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Splice mutations in the p53 gene: case report and review of the literature by Holmila, R., Fouquet, C., Cadranel, J., Zalcman, G., Soussi, T.

“…Splice mutations in the p53 gene (TP53) are described as rare events that occur at a frequency of less than 1%. Using a functional assay based on the…”
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Analysis of the most representative tumour‐derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation by Ory, K., Legros, Y., Auguin, C., Soussi, T.

“…In an effort to correlate the biological activity of the p53 protein with its conformation, we analysed 14 p53 mutants representative of the most frequently…”
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Prognostic significance of circulating P53 antibodies in patients undergoing surgery for locoregional breast cancer by Peyrat, J P, Bonneterre, J, Lubin, R, Vanlemmens, L, Fournier, J, Soussi, T

“…P53 mutations can lead to the production of P53 antibodies in serum of cancer patients. Here we studied the prognostic value of P53 antibodies in 353 primary…”
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