Search Results - "Sousa, Susana de"

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis by Takasato, Minoru, Er, Pei X., Chiu, Han S., Maier, Barbara, Baillie, Gregory J., Ferguson, Charles, Parton, Robert G., Wolvetang, Ernst J., Roost, Matthias S., Chuva de Sousa Lopes, Susana M., Little, Melissa H.

“…The kidney arises from two types of progenitors; here, the signalling conditions that induce the production of collecting ducts and functional nephrons from…”
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Rethinking organoid technology through bioengineering by Garreta, Elena, Kamm, Roger D., Chuva de Sousa Lopes, Susana M., Lancaster, Madeline A., Weiss, Ron, Trepat, Xavier, Hyun, Insoo, Montserrat, Nuria

“…In recent years considerable progress has been made in the development of faithful procedures for the differentiation of human pluripotent stem cells (hPSCs)…”
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Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development by Hochane, Mazène, van den Berg, Patrick R, Fan, Xueying, Bérenger-Currias, Noémie, Adegeest, Esmée, Bialecka, Monika, Nieveen, Maaike, Menschaart, Maarten, Chuva de Sousa Lopes, Susana M, Semrau, Stefan

“…The current understanding of mammalian kidney development is largely based on mouse models. Recent landmark studies revealed pervasive differences in renal…”
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Changes in genotoxic stress response, ribogenesis and PAP (3′‐phosphoadenosine 5′‐phosphate) levels are associated with loss of desiccation tolerance in overprimed Medicago truncatula seeds by Pagano, Andrea, Zannino, Lorena, Pagano, Paola, Doria, Enrico, Dondi, Daniele, Macovei, Anca, Biggiogera, Marco, Araújo, Susana de Sousa, Balestrazzi, Alma

“…Re‐establishment of desiccation tolerance is essential for the survival of germinated seeds facing water deficit in the soil. The molecular and ultrastructural…”
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Piwi Proteins and piRNAs in Mammalian Oocytes and Early Embryos by Roovers, Elke F., Rosenkranz, David, Mahdipour, Mahdi, Han, Chung-Ting, He, Nannan, Chuva de Sousa Lopes, Susana M., van der Westerlaken, Lucette A.J., Zischler, Hans, Butter, Falk, Roelen, Bernard A.J., Ketting, René F.

“…Germ cells of most animals critically depend on piRNAs and Piwi proteins. Surprisingly, piRNAs in mouse oocytes are relatively rare and dispensable. We present…”
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Derivation of pluripotent epiblast stem cells from mammalian embryos by Trotter, Matthew W. B, Howlett, Sarah K, Sun, Bowen, Clarkson, Amanda, Smithers, Lucy E, Pedersen, Roger A, Brons, I. Gabrielle M, Ahrlund-Richter, Lars, Rugg-Gunn, Peter, Chuva de Sousa Lopes, Susana M, Vallier, Ludovic

“…Although the first mouse embryonic stem (ES) cell lines were derived 25 years ago using feeder-layer-based blastocyst cultures, subsequent efforts to extend…”
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Physical Methods for Seed Invigoration: Advantages and Challenges in Seed Technology by Araújo, Susana de Sousa, Paparella, Stefania, Dondi, Daniele, Bentivoglio, Antonio, Carbonera, Daniela, Balestrazzi, Alma

“…In the context of seed technology, the use of physical methods for increasing plant production offers advantages over conventional treatments based on chemical…”
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Computational Stem Cell Biology: Open Questions and Guiding Principles by Cahan, Patrick, Cacchiarelli, Davide, Dunn, Sara-Jane, Hemberg, Martin, de Sousa Lopes, Susana M. Chuva, Morris, Samantha A., Rackham, Owen J.L., del Sol, Antonio, Wells, Christine A.

“…Computational biology is enabling an explosive growth in our understanding of stem cells and our ability to use them for disease modeling, regenerative…”
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Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids by Hu, Huili, Gehart, Helmuth, Artegiani, Benedetta, LÖpez-Iglesias, Carmen, Dekkers, Florijn, Basak, Onur, van Es, Johan, Chuva de Sousa Lopes, Susana M., Begthel, Harry, Korving, Jeroen, van den Born, Maaike, Zou, Chenhui, Quirk, Corrine, Chiriboga, Luis, Rice, Charles M., Ma, Stephanie, Rios, Anne, Peters, Peter J., de Jong, Ype P., Clevers, Hans

“…The mammalian liver possesses a remarkable regenerative ability. Two modes of damage response have been described: (1) The “oval cell” response emanates from…”
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Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states by Hayashi, Katsuhiko, de Sousa Lopes, Susana M Chuva, Tang, Fuchou, Lao, Kaiqin, Surani, M Azim

“…Embryonic stem cells (ESCs) are apparently homogeneous self-renewing cells, but we observed heterogeneous expression of Stella in ESCs, which is a marker of…”
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Germ Cell Specification in Mice by Hayashi, Katsuhiko, de Sousa Lopes, Susana M. Chuva, Surani, M. Azim

“…Specification of germ cells in mice occurs relatively late in embryonic development. It is initiated by signals that induce expression of Blimp1, a key…”
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Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis by Hasaart, Karlijn A. L., Manders, Freek, van der Hoorn, Marie-Louise, Verheul, Mark, Poplonski, Tomasz, Kuijk, Ewart, de Sousa Lopes, Susana M. Chuva, van Boxtel, Ruben

“…Children show a higher incidence of leukemia compared to young adolescents, yet their cells have less age-related (oncogenic) somatic mutations. Newborns with…”
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The Seed Repair Response during Germination: Disclosing Correlations between DNA Repair, Antioxidant Response, and Chromatin Remodeling in Medicago truncatula by Pagano, Andrea, Araújo, Susana de Sousa, Macovei, Anca, Leonetti, Paola, Balestrazzi, Alma

“…This work provides novel insights into the effects caused by the histone deacetylase inhibitor trichostatin A (TSA) during seed germination, with emphasis on…”
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Transcriptional progression during meiotic prophase I reveals sex-specific features and X chromosome dynamics in human fetal female germline by Fan, Xueying, Moustakas, Ioannis, Torrens-Juaneda, Vanessa, Lei, Qijing, Hamer, Geert, Louwe, Leoni A, Pilgram, Gonneke S K, Szuhai, Karoly, Matorras, Roberto, Eguizabal, Cristina, Westerlaken, Lucette van der, Mei, Hailiang, Chuva de Sousa Lopes, Susana M

“…During gametogenesis in mammals, meiosis ensures the production of haploid gametes. The timing and length of meiosis to produce female and male gametes differ…”
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Memory CD4+ T cells are generated in the human fetal intestine by Li, Na, van Unen, Vincent, Abdelaal, Tamim, Guo, Nannan, Kasatskaya, Sofya A., Ladell, Kristin, McLaren, James E., Egorov, Evgeny S., Izraelson, Mark, Chuva de Sousa Lopes, Susana M., Höllt, Thomas, Britanova, Olga V, Eggermont, Jeroen, de Miranda, Noel F. C. C., Chudakov, Dmitriy M., Price, David A., Lelieveldt, Boudewijn P. F., Koning, Frits

“…The fetus is thought to be protected from exposure to foreign antigens, yet CD45RO + T cells reside in the fetal intestine. Here we combined functional assays…”
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Fusarium Wilt Management in Legume Crops by Sampaio, Ana Margarida, Araújo, Susana de Sousa, Rubiales, Diego, Vaz Patto, Maria Carlota

“…Legumes are among the most important crops worldwide for human and animal consumption. However, yield inconsistency due to susceptibility to pests and diseases…”
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Strand-specific single-cell methylomics reveals distinct modes of DNA demethylation dynamics during early mammalian development by Sen, Maya, Mooijman, Dylan, Chialastri, Alex, Boisset, Jean-Charles, Popovic, Mina, Heindryckx, Björn, Chuva de Sousa Lopes, Susana M., Dey, Siddharth S., van Oudenaarden, Alexander

“…DNA methylation (5mC) is central to cellular identity. The global erasure of 5mC from the parental genomes during preimplantation mammalian development is…”
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DNA Methylation Landscapes of Human Fetal Development by Slieker, Roderick C, Roost, Matthias S, van Iperen, Liesbeth, Suchiman, H Eka D, Tobi, Elmar W, Carlotti, Françoise, de Koning, Eelco J P, Slagboom, P Eline, Heijmans, Bastiaan T, Chuva de Sousa Lopes, Susana M

“…Remodelling the methylome is a hallmark of mammalian development and cell differentiation. However, current knowledge of DNA methylation dynamics in human…”
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Metabolic and gene expression hallmarks of seed germination uncovered by sodium butyrate in Medicago truncatula by Pagano, Andrea, Sousa Araújo, Susana, Macovei, Anca, Dondi, Daniele, Lazzaroni, Simone, Balestrazzi, Alma

“…Because high‐quality seeds are essential for successful crop production in challenging environments, understanding the molecular bases of seed vigour will lead…”
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Tracking the progression of the human inner cell mass during embryonic stem cell derivation by O'Leary, Thomas, Heindryckx, Björn, Lierman, Sylvie, van Bruggen, David, Goeman, Jelle J, Vandewoestyne, Mado, Deforce, Dieter, de Sousa Lopes, Susana M Chuva, De Sutter, Petra

“…The events that lead from plated human blastocysts to embryonic stem cells are poorly understood. Close analysis reveals a transient intermediate state with a…”
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