Search Results - "Sousa, Pedro M"

Recent increasing frequency of compound summer drought and heatwaves in Southeast Brazil by Geirinhas, João L, Russo, Ana, Libonati, Renata, Sousa, Pedro M, Miralles, Diego G, Trigo, Ricardo M

“…Abstract An increase in the frequency of extremely hot and dry events has been experienced over the past few decades in South America, and particularly in…”
Get full text

The 'Day Zero' Cape Town drought and the poleward migration of moisture corridors by Sousa, Pedro M, Blamey, Ross C, Reason, Chris J C, Ramos, Alexandre M, Trigo, Ricardo M

“…Since 2015 the greater Cape Town area (∼3.7 million people) has been experiencing the worst drought of the last century. The combined effect of this prolonged…”
Get full text

Heat-related mortality amplified during the COVID-19 pandemic by Sousa, Pedro M., Trigo, Ricardo M., Russo, Ana, Geirinhas, João L., Rodrigues, Ana, Silva, Susana, Torres, Ana

“…Excess mortality not directly related to the virus has been shown to have increased during the COVID-19 pandemic. However, changes in heat-related mortality…”
Get full text

Climate change vulnerability assessment of the main marine commercial fish and invertebrates of Portugal by Bueno-Pardo, Juan, Nobre, Daniela, Monteiro, João N., Sousa, Pedro M., Costa, Eudriano F. S., Baptista, Vânia, Ovelheiro, Andreia, Vieira, Vasco M. N. C. S., Chícharo, Luís, Gaspar, Miguel, Erzini, Karim, Kay, Susan, Queiroga, Henrique, Teodósio, Maria A., Leitão, Francisco

“…This is the first attempt to apply an expert-based ecological vulnerability assessment of the effects of climate change on the main marine resources of…”
Get full text

Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases by Moujir, Laila, Callies, Oliver, Sousa, Pedro M.C, Sharopov, Farukh, Seca, Ana M.L

“…Sesquiterpene lactones, a vast range of terpenoids isolated from Asteraceae species, exhibit a broad spectrum of biological effects and several of them are…”
Get full text

Adductomic Screening of Hemoglobin Adducts and Monitoring of Micronuclei in School-Age Children by Carlsson, Henrik, Aasa, Jenny, Kotova, Natalia, Vare, Daniel, Sousa, Pedro F. M, Rydberg, Per, Abramsson-Zetterberg, Lilianne, Törnqvist, Margareta

“…Electrophilic compounds/metabolites present in humans, originating from endogenous processes or exogenous exposure, pose a risk to health effects through their…”
Get full text

Association between Prevailing Circulation Patterns and Coarse Particles in Portugal by Cavaleiro, Rui, Russo, Ana, Sousa, Pedro M., Durão, Rita

“…Air pollution is one of the major environmental concerns today, with high socio-economic and public health impacts, which are expected to worsen in the future…”
Get full text

Screening Pyridine Derivatives against Human Hydrogen Sulfide-synthesizing Enzymes by Orthogonal Methods by Zuhra, Karim, Sousa, Pedro M. F., Paulini, Giulia, Lemos, Ana Rita, Kalme, Zenta, Bisenieks, Imants, Bisenieks, Egils, Vigante, Brigita, Duburs, Gunars, Bandeiras, Tiago M., Saso, Luciano, Giuffrè, Alessandro, Vicente, João B.

“…Biosynthesis of hydrogen sulfide (H 2 S), a key signalling molecule in human (patho)physiology, is mostly accomplished by the human enzymes cystathionine…”
Get full text

Novel scFv against Notch Ligand JAG1 Suitable for Development of Cell Therapies toward JAG1-Positive Tumors by Silva, Gabriela, Rodrigues, Ana F, Ferreira, Susana, Matos, Carolina, Eleutério, Rute P, Marques, Gonçalo, Kucheryava, Khrystyna, Lemos, Ana R, Sousa, Pedro M F, Castro, Rute, Barbas, Ana, Simão, Daniel, Alves, Paula M

“…The Notch signaling ligand JAG1 is overexpressed in various aggressive tumors and is associated with poor clinical prognosis. Hence, therapies targeting…”
Get full text

Extract2Chip—Bypassing Protein Purification in Drug Discovery Using Surface Plasmon Resonance by Paiva, Ana C. F., Lemos, Ana R., Busse, Philipp, Martins, Madalena T., Silva, Diana O., Freitas, Micael C., Santos, Sandra P., Freire, Filipe, Barrey, Evelyne J., Manival, Xavier, Koetzner, Lisa, Heinrich, Timo, Wegener, Ansgar, Grädler, Ulrich, Bandeiras, Tiago M., Schwarz, Daniel, Sousa, Pedro M. F.

“…Modern drug discovery relies on combinatorial screening campaigns to find drug molecules targeting specific disease-associated proteins. The success of such…”
Get full text

Simultaneous RNA and DNA Adductomics Using Single Data-Independent Acquisition Mass Spectrometry Analysis by Martella, Giulia, Motwani, Nisha H., Khan, Zareen, Sousa, Pedro F. M., Gorokhova, Elena, Motwani, Hitesh V.

“…Adductomics studies are used for the detection and characterization of various chemical modifications (adducts) of nucleic acids and proteins. The advancements…”
Get full text

Research Advances on Health Effects of Edible Artemisia Species and Some Sesquiterpene Lactones Constituents by Trendafilova, Antoaneta, Moujir, Laila M., Sousa, Pedro M. C., Seca, Ana

“…The genus Artemisia, often known collectively as “wormwood”, has aroused great interest in the scientific community, pharmaceutical and food industries,…”
Get full text

Selective iteratively reweighted quantile regression for baseline correction by Liu, Xinbo, Zhang, Zhimin, Sousa, Pedro F. M., Chen, Chen, Ouyang, Meilan, Wei, Yangchao, Liang, Yizeng, Chen, Yong, Zhang, Chaoping

“…Extraction of qualitative and quantitative information from large numbers of analytical signals is difficult with drifted baselines, particularly in…”
Get full text

The aerobic respiratory chain of Escherichia coli: from genes to supercomplexes by SOUSA, Pedro M. F, VIDEIRA, Marco A. M, BOHN, Andreas, HOOD, Brian L, CONRADS, Thomas P, GOULAO, Luis F, MELO, Ana M. P

“…In spite of the large number of reports on the aerobic respiratory chain of Escherichia coli, from gene transcription regulation to enzyme kinetics and…”
Get full text

DNA Adductomics for the Biological Effect Assessment of Contaminant Exposure in Marine Sediments by Martella, Giulia, Gorokhova, Elena, Sousa, Pedro F. M., Tretyakova, Natalia Y., Sundelin, Brita, Motwani, Hitesh V.

“…Exposure to chemical pollution can induce genetic and epigenetic alterations, developmental changes, and reproductive disorders, leading to population declines…”
Get full text

High-throughput Screening of Human Tumor Antigen-specific CD4 T Cells, Including Neoantigen-reactive T Cells by Costa-Nunes, Carla, Cachot, Amélie, Bobisse, Sara, Arnaud, Marion, Genolet, Raphael, Baumgaertner, Petra, Speiser, Daniel E, Sousa Alves, Pedro M, Sandoval, Federico, Adotévi, Olivier, Reith, Walter, Protti, Maria Pia, Coukos, George, Harari, Alexandre, Romero, Pedro, Jandus, Camilla

“…Characterization of tumor antigen-specific CD4 T-cell responses in healthy donors and malignant melanoma patients using an amplified T-cell library screening…”
Get full text

Deciphering cellular and molecular determinants of human DPCD protein in complex with RUVBL1/RUVBL2 AAA-ATPases by Dos Santos Morais, Raphael, Santo, Paulo E., Ley, Marie, Schelcher, Cédric, Abel, Yoann, Plassart, Laura, Deslignière, Evolène, Chagot, Marie-Eve, Quinternet, Marc, Paiva, Ana C.F., Hessmann, Steve, Morellet, Nelly, M. F. Sousa, Pedro, Vandermoere, Franck, Bertrand, Edouard, Charpentier, Bruno, Bandeiras, Tiago M., Plisson-Chastang, Célia, Verheggen, Céline, Cianférani, Sarah, Manival, Xavier

“…[Display omitted] •DPCD is a new RUVBL1/RUVBL2 cofactor.•3 DPCD interact with 1 RUVBL1/RUVBL2 heterohexamer with sub-micromolar affinity.•DPCD regulates the…”
Get full text

European temperature responses to blocking and ridge regional patterns by Sousa, Pedro M., Trigo, Ricardo M., Barriopedro, David, Soares, Pedro M. M., Santos, João A.

“…Blocking occurrence and its impacts on European temperature have been studied in the last decade. However, most previous studies on blocking impacts have…”
Get full text

Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors by Seixas, João D., Sousa, Bárbara B., C. Marques, Marta, dos Santos Guerreiro, Ana Maria, Traquete, Rui, Rodrigues, Tiago, S. Albuquerque, Inês, Sousa, Marcos F. Q., Lemos, Ana R., Sousa, Pedro M. F., Bandeiras, Tiago M., Wu, Di, Doyle, Shelby K., Robinson, Carol V., Koehler, Angela N., Corzana, Francisco, Matias, Pedro M., Bernardes, Gonçalo

“…This journal is © The Royal Society of Chemistry 2020. The bone marrow tyrosine kinase in chromosome X (BMX) is pursued as a drug target because of its role in…”
Get full text

The formate:oxygen oxidoreductase supercomplex of Escherichia coli aerobic respiratory chain by Sousa, Pedro M.F., Videira, Marco A.M., Melo, Ana M.P.

“…•Escherichia coli FdOx supercomplex has KCN-sensitive formate:oxygen oxidoreductase activity.•Cytochromes bo3 and bdI associate with FDH-O in FdOx…”
Get full text