Ovariectomy Modifies TH2, and TH17 Balance in BALB/C Allergic Mice

Ovariectomy Modifies TH2, and TH17 Balance in BALB/C Allergic Mice

Asthma is a chronic inflammation of the airways affecting over 300 million people worldwide. As in the autoimmune diseases, it is well described that women are the most affected by asthma. The higher number of women presenting this pathology suggests the involvement of female sex hormones in the con...

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Published in:Iranian journal of allergy, asthma, and immunology Vol. 16; no. 6; pp. 525 - 536
Main Authors: Souza, Marcos Paulo Almeida, Lima, Fernanda Macedo da Silva, Muniz, Igor Pereira, Pereira, Ítalo Sousa, Sousa, Larissa Rodrigues de Oliveira, Galantini, Maria Poliana Leite, Santos, Denisar Palmito Dos, Figueiredo, Tiana Baqueiro, Silva, Robson Amaro Augusto da
Format: Journal Article
Language:English
Published: Iran Tehran University of Medical Sciences 01-12-2017
Subjects:
Airway inflammation
Alveoli
Animals
Asthma
Autoimmune diseases
Body weight
Bronchus
Eosinophils
Females
Helper cells
Hypersensitivity
IL-17A
Immune response
Immunoglobulin G
Inflammation
Leukocytes (eosinophilic)
Lungs
Lymphocytes T
Mast cells
Mice
Ovariectomy
Rodents
Sex hormones
Uterus
Sex hormones
Airway inflammation
IL-17A
Ovariectomy
Asthma
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Summary:Asthma is a chronic inflammation of the airways affecting over 300 million people worldwide. As in the autoimmune diseases, it is well described that women are the most affected by asthma. The higher number of women presenting this pathology suggests the involvement of female sex hormones in the construction of the allergic immune response. Female Balb / c mice were used for the experiments. Thirty-eight animals were separated into four groups: OVX-Ova; Sham-Ova; OVX-Sal; Sham-Sal. Then animals underwent acute allergic induction protocol by Ovalbulmin (OVA). Ovariectomized animals showed greater number of leukocytes in bronchoalveolar lavage (BAL) and elevated white blood cells recruitment to the lung environment observed by histological analysis. There was a significant increase of eosinophils and mast cells in inflammatory sites at pulmonary tissue. The relative uterine and body weight were lower in ovariectomized animals and higher in Sham mice, respectively. Moreover, the lack of the sex hormones induced an increase in interleukin (IL)-4 and titers of immunoglobulin G1 (IgG1) antibodies. However, increased production of IL-17A was only observed in Sham animals. Altogether, data this study suggest that ovariectomy induces the formation of a stronger Th2 response in allergic animal. However, the immune processes involved in the allergic response in females currently remain unclear.
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ISSN:1735-1502
1735-5249