Search Results - "Sousa, Kyle M"

Vertical sleeve gastrectomy activates GPBAR‐1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice by Ding, Lili, Sousa, Kyle M., Jin, Lihua, Dong, Bingning, Kim, Byung‐Wook, Ramirez, Ricardo, Xiao, Zhenzhou, Gu, Ying, Yang, Qiaoling, Wang, Jie, Yu, Donna, Pigazzi, Alessio, Schones, Dustin, Yang, Li, Moore, David, Wang, Zhengtao, Huang, Wendong

“…Vertical sleeve gastrectomy (VSG) is one of the most commonly performed clinical bariatric surgeries used for the remission of obesity and diabetes. However,…”
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Roles for miRNA-378/378 in adipocyte gene expression and lipogenesis by Gerin, Isabelle, Bommer, Guido T, McCoin, Colin S, Sousa, Kyle M, Krishnan, Venkatesh, MacDougald, Ormond A

“…In this study, we explored the roles of microRNAs in adipocyte differentiation and metabolism. We first knocked down Argonaute2 (Ago2), a key enzyme in the…”
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Wnt10b Increases Postnatal Bone Formation by Enhancing Osteoblast Differentiation by Bennett, Christina N, Ouyang, Hongjiao, Ma, Yanfei L, Zeng, Qingqiang, Gerin, Isabelle, Sousa, Kyle M, Lane, Timothy F, Krishnan, Venkatesh, Hankenson, Kurt D, MacDougald, Ormond A

“…Overexpression of Wnt10b from the osteocalcin promoter in transgenic mice increases postnatal bone mass. Increases in osteoblast perimeter, mineralizing…”
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Endocannabinoids Regulate Interneuron Migration and Morphogenesis by Transactivating the TrkB Receptor by Paul Berghuis, Marton B. Dobszay, Xinyu Wang, Sabrina Spano, Fernanda Ledda, Kyle M. Sousa, Gunnar Schulte, Ernfors, Patrik, Mackie, Ken, Gustavo Paratcha, Yasmin L. Hurd, Tibor Harkany

“…In utero exposure to$\Delta^9-tetrahydrocannabinol$($\Delta^9-THC$, the active component from marijuana, induces cognitive deficits enduring into adulthood…”
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Wnt2 Regulates Progenitor Proliferation in the Developing Ventral Midbrain by Sousa, Kyle M., Villaescusa, J. Carlos, Cajanek, Lukas, Ondr, Jennifer K., Castelo-Branco, Goncalo, Hofstra, Wytske, Bryja, Vitezslav, Palmberg, Carina, Bergman, Tomas, Wainwright, Brandon, Lang, Richard A., Arenas, Ernest

“…Wnts are secreted, lipidated proteins that regulate multiple aspects of brain development, including dopaminergic neuron development. In this study, we perform…”
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Bariatric surgery attenuates colitis in an obese murine model by Li, Shiri, M.D., Ph.D, Vinci, Alessio, M.D, Behnsen, Judith, Ph.D, Cheng, Chunmei, M.D., Ph.D, Jellbauer, Stefan, Ph.D, Raffatellu, Manuela, M.D, Sousa, Kyle M., Ph.D, Edwards, Robert, M.D., Ph.D, Nguyen, Ninh T., M.D, Stamos, Michael J., M.D, Pigazzi, Alessio, M.D., Ph.D

“…Abstract Background Obesity and inflammatory bowel disease (IBD) represent chronic inflammatory conditions. Bariatric surgery improves some obesity-related…”
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Brain-derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively isolated fast-spiking GABAergic interneurons by Berghuis, Paul, Dobszay, Marton B., Sousa, Kyle M., Schulte, Gunnar, Mager, Peter P., Härtig, Wolfgang, Görcs, Tamás J., Zilberter, Yuri, Ernfors, Patrik, Harkany, Tibor

“…GABAergic interneurons with high‐frequency firing, fast‐spiking (FS) cells, form synapses on perisomatic regions of principal cells in the neocortex and…”
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Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice by Ding, Lili, Zhang, Eryun, Yang, Qiaoling, Jin, Lihua, Sousa, Kyle M., Dong, Bingning, Wang, Yangmeng, Tu, Jui, Ma, Xiaoxiao, Tian, Jingyan, Zhang, Hongli, Fang, Zhipeng, Guan, Ana, Zhang, Yixin, Wang, Zhengtao, Moore, David D., Yang, Li, Huang, Wendong

“…Vertical sleeve gastrectomy (VSG) is one of the most effective and durable therapies for morbid obesity and its related complications. Although bile acids…”
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Targeted lipidomic analysis of oxysterols in the embryonic central nervous system by Wang, Yuqin, Sousa, Kyle M, Bodin, Karl, Theofilopoulos, Spyridon, Sacchetti, Paola, Hornshaw, Martin, Woffendin, Gary, Karu, Kersti, Sjövall, Jan, Arenas, Ernest, Griffiths, William J

“…In this study two regions of embryonic (E11) mouse central nervous system (CNS) have been profiled for their unesterified sterol content. Using…”
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Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis by Theofilopoulos, Spyridon, Wang, Yuqin, Kitambi, Satish Srinivas, Sacchetti, Paola, Sousa, Kyle M, Bodin, Karl, Kirk, Jayne, Saltó, Carmen, Gustafsson, Magnus, Toledo, Enrique M, Karu, Kersti, Gustafsson, Jan-Åke, Steffensen, Knut R, Ernfors, Patrik, Sjövall, Jan, Griffiths, William J, Arenas, Ernest

“…Cholic acid and 24( S ),25-epoxycholesterol are endogenous midbrain LXR ligands that are neurogenic for red nucleus or dopaminergic neurons, respectively…”
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Stereoselective synthesis, biological evaluation, and modeling of novel bile acid-derived G-protein coupled Bile acid receptor 1 (GP-BAR1, TGR5) agonists by Yu, Donna D., Sousa, Kyle M., Mattern, Daniell L., Wagner, Jeffrey, Fu, Xianghui, Vaidehi, Nagarajan, Forman, Barry M., Huang, Wendong

“…[Display omitted] GP-BAR1 (also known as TGR5), a novel G-protein coupled receptor regulating various non-genomic functions via bile acid signaling, has…”
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Continuous-Flow Enzyme Assay on a Microfluidic Chip for Monitoring Glycerol Secretion from Cultured Adipocytes by Clark, Anna M, Sousa, Kyle M, Jennings, Colin, MacDougald, Ormond A, Kennedy, Robert T

“…A dual-chip microfluidic platform that coupled perfusion of cultured adipocytes with on-line fluorescence-based enzyme assay was developed to monitor glycerol…”
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Liver X Receptors and Oxysterols Promote Ventral Midbrain Neurogenesis In Vivo and in Human Embryonic Stem Cells by Sacchetti, Paola, Sousa, Kyle M., Hall, Anita C., Liste, Isabel, Steffensen, Knut R., Theofilopoulos, Spyridon, Parish, Clare L., Hazenberg, Carin, Richter, Lars Ährlund, Hovatta, Outti, Gustafsson, Jan-Åke, Arenas, Ernest

“…Control over progenitor proliferation and neurogenesis remains a key challenge for stem cell neurobiology and a prerequisite for successful stem cell…”
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Report of the 2018-2019 Student Affairs Standing Committee by Schoelles-Williams, Jennifer, English, Dale E., Godwin, Donald A, Hammond, Lauren, Mason, Holly L., Petrelli, Heather M.W., Roni, Monzurul, Sousa, Kyle M., Van Amburgh, Jenny A., Ross, Libby J.

“…The 2018-2019 Student Affairs Standing Committee addressed charges related to examining the institutional leadership models and professional development needs…”
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Purified Wnt‐5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation by Schulte, Gunnar, Bryja, Vítězslav, Rawal, Nina, Castelo‐Branco, Goncalo, Sousa, Kyle M., Arenas, Ernest

“…The Wnt family of lipoproteins regulates several aspects of the development of the nervous system. Recently, we reported that Wnt‐3a enhances the proliferation…”
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Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion by Castelo-Branco, Gonçalo, Sousa, Kyle M., Bryja, Vitezslav, Pinto, Luisa, Wagner, Joseph, Arenas, Ernest

“…Glial cells have been classically described as supporting cells for neurons. Recently, additional roles during neural development have begun to emerge. Here,…”
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Reversibly sealed multilayer microfluidic device for integrated cell perfusion and on-line chemical analysis of cultured adipocyte secretions by Clark, Anna M, Sousa, Kyle M, Chisolm, Claire N, MacDougald, Ormond A, Kennedy, Robert T

“…A three-layer microfluidic device was developed that combined perfusion of cultured cells with on-line chemical analysis for near real-time monitoring of…”
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Delayed dopaminergic neuron differentiation in Lrp6 mutant mice by Castelo‐Branco, Gonçalo, Andersson, Emma R., Minina, Eleonora, Sousa, Kyle M., Ribeiro, Diogo, Kokubu, Chikara, Imai, Kenji, Prakash, Nilima, Wurst, Wolfgang, Arenas, Ernest

“…Wnts are known to bind and activate multiple membrane receptors/coreceptors and to regulate dopaminergic (DA) neuron development and ventral midbrain (VM)…”
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Non-fibrillar β-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors by Shemer, Isaac, Holmgren, Carl, Min, Rogier, Fülöp, Livia, Zilberter, Misha, Sousa, Kyle M., Farkas, Tamás, Härtig, Wolfgang, Penke, Botond, Burnashev, Nail, Tanila, Heikki, Zilberter, Yuri, Harkany, Tibor

“…Cognitive decline in Alzheimer's disease (AD) stems from the progressive dysfunction of synaptic connections within cortical neuronal microcircuits. Recently,…”
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Dynamic temporal and cell type-specific expression of Wnt signaling components in the developing midbrain by Rawal, Nina, Castelo-Branco, Gonçalo, Sousa, Kyle M., Kele, Julianna, Kobayashi, Kazuto, Okano, Hideyuki, Arenas, Ernest

“…Wnt1 and -5a have been shown to modulate the proliferation and differentiation of midbrain dopaminergic (DA) neurons. However, it is not known whether other…”
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