Pseudoboehmite as a drug delivery system for acyclovir

Pseudoboehmite as a drug delivery system for acyclovir

Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and it is indicated for the treatment and management of recurrent cold sores on the lips and face, genital herpes, among other diseases. The problem of the o...

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Published in:Scientific reports Vol. 11; no. 1; p. 15448
Main Authors: Peres, Renato Meneghetti, Sousa, Jéssica Maiara Leme, de Oliveira, Mariana Oliva, Rossi, Maura Vincenza, de Oliveira, Rene Ramos, de Lima, Nelson Batista, Bernussi, Ayrton, Warzywoda, Juliusz, Sarmento, Bruno, Munhoz, Antonio Hortencio
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 29-07-2021
Nature Publishing Group
Nature Portfolio
Subjects:
639/301/357
639/301/54
Acyclovir
Aluminum
Ammonium
Antiviral drugs
Bioavailability
Drug delivery
Drug delivery systems
Herpes labialis
Herpes simplex
Humanities and Social Sciences
Infrared spectroscopy
Membrane permeability
multidisciplinary
Nanoparticles
Permeability
Rodents
Science
Science (multidisciplinary)
Sexually transmitted diseases
STD
Toxicity
Transmission electron microscopy
X-ray diffraction
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Summary:Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and it is indicated for the treatment and management of recurrent cold sores on the lips and face, genital herpes, among other diseases. The problem of the oral bioavailability of acyclovir is limited because of the low permeability across the gastrointestinal membrane. The use of nanoparticles of pseudoboehmite as a drug delivery system in vitro assays is a promising approach to further the permeability of acyclovir release. Here we report the synthesis of high purity pseudoboehmite from aluminium nitrate and ammonium hydroxide containing nanoparticles, using the sol–gel method, as a drug delivery system to improve the systemic bioavailability of acyclovir. The presence of pseudoboehmite nanoparticles were verified by infrared spectroscopy, transmission electron microscopy, and X-ray diffraction techniques. In vivo tests were performed with Wistar rats to compare the release of acyclovir, with and without the addition of pseudoboehmite. The administration of acyclovir with the addition of pseudoboehmite increased the drug content by 4.6 times in the plasma of Wistar rats after 4 h administration. We determined that the toxicity of pseudoboehmite is low up to 10 mg/mL, in gel and the dried pseudoboehmite nanoparticles.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-94325-y