Effects of Caffeine on Behavioural and Cognitive Deficits in Rats

There are many studies that have sought to find drug therapies to prevent harm arising from sepsis. Such studies have represented a progress in the support to septic patients and also in the development of new pharmacological alternatives. Our interest was to investigate the caffeine effect on sepsi...

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Published in:	Basic & clinical pharmacology & toxicology Vol. 123; no. 4; pp. 435 - 442
Main Authors:	Assis, Melissa S., Soares, Aluízio C., Sousa, Dircilei N., Eudes‐Filho, João, Faro, Lilian Rosana F., Carneiro, Fabiana P., Silva, Mônica V., Motoyama, Andrea B., Souza, Greice Maria R., Marchiori, Stéphanie, Lima, Nadyelle T., Boëchat‐Barros, Raphael, Ferreira, Vania M.
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01-10-2018
Subjects:	Adenosine receptors Animals Avoidance Behavior, Animal - drug effects Caffeine Caffeine - pharmacology Cognition Cognition - drug effects Cognition Disorders - microbiology Cognition Disorders - prevention & control Cognition Disorders - psychology Cognitive ability Disease Models, Animal Latency Male Maze Learning - drug effects Memory Memory - drug effects Motor Activity - drug effects Perforation Peritoneum Purinergic P1 Receptor Antagonists - pharmacology Rats, Wistar Reaction Time - drug effects Receptors Sepsis Sepsis - complications Sepsis - drug therapy Sepsis - microbiology Sepsis - psychology Surgery Time Factors
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Summary:	There are many studies that have sought to find drug therapies to prevent harm arising from sepsis. Such studies have represented a progress in the support to septic patients and also in the development of new pharmacological alternatives. Our interest was to investigate the caffeine effect on sepsis behavioural and memory impairments. Male rats were anaesthetized and the surgery was made to allow exposure of the caecum, which was then squeezed to extrude a small amount of faeces from the perforation site, which was later placed back into the peritoneal cavity. This procedure, which served to generate experimental sepsis, is herein referred to as ceccum ligation and perforation (CLP). The caffeine (10 mg/kg) was administered by gavage route, once daily, during 7 or 14 consecutive days to investigate the effects of acute or subchronic caffeine treatment on long‐term behavioural and cognitive deficits induced by CLP. On the last day, 1 hr after caffeine administration, the animals were submitted to open‐field, elevated plus maze (EPM), forced swimming and step‐down inhibitory avoidance tests. The results showed that caffeine increased the percentage of open arm entries and open arm time in the EPM test, and reduced the immobility time when compared to the sham‐operated group. The caffeine also increased the latency in the inhibitory avoidance test platform. Our results demonstrated that the caffeine improved behavioural changes and improved the neurocognitive deficits of sepsis‐surviving animals. It is possible that blockage of the adenosine receptors may be responsible for the results here observed.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1742-7835 1742-7843
DOI:	10.1111/bcpt.13036