Search Results - "Sousa, Dave De"

The circadian clock of CD8 T cells modulates their early response to vaccination and the rhythmicity of related signaling pathways by Nobis, Chloé C., Laramée, Geneviève Dubeau, Kervezee, Laura, De Sousa, Dave Maurice, Labrecque, Nathalie, Cermakian, Nicolas

“…Circadian variations of various aspects of the immune system have been described. However, the circadian control of T cells has been relatively unexplored…”
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516 Caspase-8 regulated senescence as an immune checkpoint in T lymphocytes for adoptive cell therapy by Janelle, Valérie, Neault, Mathieu, Lebel, Marie-Eve, Sousa, Dave De, Boulet, Salix, Durrieu, Ludovic, Carli, Cedric, Lemieux, Sebastien, Labrecque, Nathalie, Melichar, Heather, Mallette, Frederick, Delisle, Jean-Sebastien

“…BackgroundThe development of immunotherapies holds great promise for the treatment of refractory infections and cancer. Current approaches, although effective…”
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Early programming of CD8⁺ T cell response by the orphan nuclear receptor NR4A3 by Odagiu, Livia, Boulet, Salix, De Sousa, Dave Maurice, Daudelin, Jean-François, Nicolas, Sandrine, Labrecque, Nathalie

“…Enhancing long-term persistence while simultaneously potentiating the effector response of CD8⁺ T cells has been a long-standing goal in immunology to produce…”
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GCNT1-Mediated O -Glycosylation of the Sialomucin CD43 Is a Sensitive Indicator of Notch Signaling in Activated T Cells by Perkey, Eric, Maurice De Sousa, Dave, Carrington, Léolène, Chung, Jooho, Dils, Alexander, Granadier, David, Koch, Ute, Radtke, Freddy, Ludewig, Burkhard, Blazar, Bruce R, Siebel, Christian W, Brennan, Todd V, Nolz, Jeffrey, Labrecque, Nathalie, Maillard, Ivan

“…Notch signaling is emerging as a critical regulator of T cell activation and function. However, there is no reliable cell surface indicator of Notch signaling…”
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The Notch signaling pathway controls CD8+ T cell differentiation independently of the classical effector HES1 by De Sousa, Dave Maurice, Duval, Frédéric, Daudelin, Jean-François, Boulet, Salix, Labrecque, Nathalie

“…During CD8+ T cell response, Notch signaling controls short-lived-effector-cell (SLEC) generation, but the exact mechanisms by which it does so remains…”
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p16INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells by Janelle, Valérie, Neault, Mathieu, Lebel, Marie-Ève, De Sousa, Dave Maurice, Boulet, Salix, Durrieu, Ludovic, Carli, Cédric, Muzac, Chloé, Lemieux, Sébastien, Labrecque, Nathalie, Melichar, Heather J., Mallette, Frédérick A., Delisle, Jean-Sébastien

“…T-cell dysfunction arising upon repeated antigen exposure prevents effective immunity and immunotherapy. Using various clinically and physiologically relevant…”
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Role of the Notch-TRIB2 axis in CD8+ T cell differentiation by Le Corre, Laure, Boulet, Salix, De Sousa, Dave Maurice, Labrecque, Nathalie

“…Following activation, naïve CD8+ T cells expand and differentiate into two effector subpopulations: short-lived effector cells (SLECs) and memory precursor…”
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The Notch signaling pathway controls CD8.sup.+ T cell differentiation independently of the classical effector HES1 by De Sousa, Dave Maurice, Duval, Frédéric, Daudelin, Jean-François, Boulet, Salix, Labrecque, Nathalie

“…During CD8.sup.+ T cell response, Notch signaling controls short-lived-effector-cell (SLEC) generation, but the exact mechanisms by which it does so remains…”
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p16 INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells by Janelle, Valérie, Neault, Mathieu, Lebel, Marie-Ève, De Sousa, Dave Maurice, Boulet, Salix, Durrieu, Ludovic, Carli, Cédric, Muzac, Chloé, Lemieux, Sébastien, Labrecque, Nathalie, Melichar, Heather J, Mallette, Frédérick A, Delisle, Jean-Sébastien

“…T-cell dysfunction arising upon repeated antigen exposure prevents effective immunity and immunotherapy. Using various clinically and physiologically relevant…”
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