Search Results - "Souroujon, M C"

Peptide modulators of protein-protein interactions in intracellular signaling by Souroujon, Miriam C, Mochly-Rosen, Daria

“…Signal transduction cascades involve multiple enzymes and are orchestrated by selective protein-protein interactions that are essential for the progression of…”
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Overexpression of amyloid precursor protein reduces epsilon protein kinase C levels by Liron, T, Seraya, C. Bareket, Ish-Shalom, M, Souroujon, M.C, Neumann, D

“…Abstract Alzheimer’s disease (AD) is characterized by extracellular deposits of amyloid beta peptide (Aβ), a peptide that is generated upon proteolytic…”
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Development of novel therapies for MG: Studies in animal models by Souroujon, M. C., Brenner, T., Fuchs, S.

“…Experimental myasthenia gravis (MG) in animals, and in particular experimental autoimmune MG in rodents, serves as excellent models to study possible novel…”
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Antigen-Specific Modulation of Experimental Myasthenia Gravis: Nasal Tolerization with Recombinant Fragments of the Human Acetylcholine Receptor α -Subunit by Barchan, Dora, Souroujon, Miriam C., Im, Sin-Hyeog, Antozzi, Carlo, Fuchs, Sara

“…Myasthenia gravis (MG) and experimental autoimmune myasthenia gravis (EAMG) are antibody-mediated autoimmune diseases in which the nicotinic acetylcholine…”
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Role of Tolerogen Conformation in Induction of Oral Tolerance in Experimental Autoimmune Myasthenia Gravis by Im, Sin-Hyeog, Barchan, Dora, Souroujon, Miriam C, Fuchs, Sara

“…We recently demonstrated that oral or nasal administration of recombinant fragments of the acetylcholine receptor (AChR) prevents the induction of experimental…”
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Sustained in vivo Cardiac Protection by a Rationally Designed Peptide That Causes ε Protein Kinase C Translocation by Dorn, Gerald W., Souroujon, Miriam C., Liron, Tamar, Chen, Che-Hong, Gray, Mary O., Zhou, Hui Zhong, Csukai, Michael, Wu, Guangyu, Lorenz, John N., Mochly-Rosen, Daria

“…Brief periods of cardiac ischemia trigger protection from subsequent prolonged ischemia (preconditioning). ε Protein kinase C (ε PKC) has been suggested to…”
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Increased gene expression of acetylcholine receptor and myogenic factors in passively transferred experimental autoimmune myasthenia gravis by Asher, O, Kues, WA, Witzemann, V, Tzartos, SJ, Fuchs, S, Souroujon, MC

“…The passive transfer of myasthenia gravis by injection of mAb against muscle acetylcholine receptor (AChR) alpha-subunit, results in increased expression of…”
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Blockade of CD40 Ligand Suppresses Chronic Experimental Myasthenia Gravis by Down-Regulation of Th1 Differentiation and Up-Regulation of CTLA-4 by Im, Sin-Hyeog, Barchan, Dora, Maiti, Prasanta Kumar, Fuchs, Sara, Souroujon, Miriam C

“…Myasthenia gravis (MG) and experimental autoimmune MG (EAMG) are T cell-dependent Ab-mediated autoimmune disorders, in which the nicotinic acetylcholine…”
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Acetylcholine receptor and myogenic factor gene expression in Torpedo embryonic development by Asher, O, Fuchs, S, Souroujon, M C

“…The mRNA levels of acetylcholine receptor (AChR) and myogenic factors were followed during embryonic development of Torpedo skeletal muscle and its homologue,…”
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Immunosuppression of rat myasthenia gravis by oral administration of a syngeneic acetylcholine receptor fragment by Maiti, Prasanta K, Feferman, Tali, Im, Sin-Hyeog, Souroujon, Miriam C, Fuchs, Sara

“…A syngeneic rat recombinant fragment of the extracellular domain of the acetylcholine receptor (AChR) α-subunit (Rα1–205), administered orally, suppresses…”
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Suppression of ongoing experimental myasthenia by oral treatment with an acetylcholine receptor recombinant fragment by Im, S H, Barchan, D, Fuchs, S, Souroujon, M C

“…Myasthenia gravis (MG) is an autoimmune disorder in which the nicotinic acetylcholine receptor (AChR) is the major autoantigen. In an attempt to develop an…”
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Mapping of the cAMP‐dependent phosphorylation sites on the acetylcholine receptor by Souroujon, M.C., Neumann, D., Pizzighella, S., Fridkin, M., Fuchs, S.

“…We have synthesized a tetradecapeptide corresponding to residues 354‐367 of the delta‐subunit of Torpedo acetylcholine receptor. This peptide contains the…”
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Suppression of experimental myasthenia gravis, a B cell‐mediated autoimmune disease, by blockade of IL‐18 by Im, Sin‐Hyeog, Barchan, Dora, Maiti, Prasanta Kumar, Raveh, Lily, Souroujon, Miriam C., Fuchs, Sara

“…Interleukin‐18 (IL‐18) is a pleiotropic proinflammatory cytokine that plays an important role in interferon gamma (IFN‐γ) production and IL‐12‐driven Th1…”
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Breakage of tolerance to hidden cytoplasmic epitopes of the acetylcholine receptor in experimental autoimmune myasthenia gravis by Feferman, Tali, Im, Sin-Hyeog, Fuchs, Sara, Souroujon, Miriam C

“…The acetylcholine receptor (AChR) is the major autoantigen in the antibody-mediated disease myasthenia gravis (MG) and its animal model experimental autoimmune…”
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Differences between embryonic and adult Torpedo acetylcholine receptor γ subunit by Souroujon, Miriam C., Carmon, Sara, Safran, Anat, Fuchs, Sara

“…Antibodies to a synthetic peptide corresponding to residues 346–359 of the Torpedo acetylcholine receptor (AChR) γ subunit, were employed to compare the adult…”
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Mechanism of nasal tolerance induced by a recombinant fragment of acetylcholine receptor for treatment of experimental myasthenia gravis by Im, Sin-Hyeog, Barchan, Dora, Fuchs, Sara, Souroujon, Miriam C

“…Acetylcholine receptor (AChR) is the major autoantigen in myasthenia gravis (MG) and experimental autoimmune MG (EAMG). Here we analyze the mechanisms involved…”
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Protective molecular mimicry in experimental myasthenia gravis by Im, Sin-Hyeog, Barchan, Dora, Feferman, Tali, Raveh, Lily, Souroujon, Miriam C, Fuchs, Sara

“…Protein databases were searched for microbial sequences that bear amino acid similarities with identified T- or B-cell epitopes within the human α-subunit of…”
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Interaction of monoclonal antibodies to Torpedo acetylcholine receptor with the receptor of skeletal muscle by Souroujon, M C, Mochly-Rosen, D, Gordon, A S, Fuchs, S

“…Several monoclonal antibodies (mcAbs) elicited against the nicotinic acetylcholine receptor (AChR) from Torpedo react also with skeletal muscle AChR. Such…”
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Modulation of the anti‐acetylcholine receptor response and experimental autoimmune myasthenia gravis by recombinant fragments of the acetylcholine receptor by Barchan, Dora, Asher, Orna, Tzartos, Socrates J., Fuchs, Sara, Souroujon, Miriam C.

“…Myasthenia gravis (MG) is a neuromuscular disorder of man caused by a humoral response to the acetylcholine receptor (AChR). Most of the antibodies in MG and…”
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Analysis and modulation of the immune response of mice to acetylcholine receptor by anti-idiotypes by Souroujon, M C, Barchan, D, Fuchs, S

“…Anti-idiotypes were raised in mice against three well-characterized anti-acetylcholine receptor (AChR) monoclonal antibodies (mcAbs), as well as against…”
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