Search Results - "Soukup, O"

Antimicrobial susceptibility testing: currently used methods and devices and the near future in clinical practice by Benkova, M., Soukup, O., Marek, J.

“…Summary Rapid identification of pathogen and its resistance to antimicrobial drugs, and subsequent appropriate antimicrobial treatment are essential for…”
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The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease by Hepnarova, V., Korabecny, J., Matouskova, L., Jost, P., Muckova, L., Hrabinova, M., Vykoukalova, N., Kerhartova, M., Kucera, T., Dolezal, R., Nepovimova, E., Spilovska, K., Mezeiova, E., Pham, N.L., Jun, D., Staud, F., Kaping, D., Kuca, K., Soukup, O.

“…Novel tacrine-benzyl quinolone carboxylic acid (tacrine-BQCA) hybrids were designed based on multi-target directed ligands (MTLDs) paradigm, synthesized and…”
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UHPLC-Orbitrap study of the first phase tacrine in vitro metabolites and related Alzheimer's drug candidates using human liver microsomes by Novak, M., Svobodova, B., Konecny, J., Kuratkova, A., Nevosadova, L., Prchal, L., Korabecny, J., Lauschke, V.M., Soukup, O., Kučera, R.

“…Tacrine was the first drug used in the therapy of Alzheimer’s disease (AD) and is one of the leading structures frequently pursued in the drug discovery of…”
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The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors by Soukup, O., Jun, D., Tobin, G., Kuca, K.

“…Organophosphorus inhibitors (OP) of acetylcholinesterase (AChE) represent a group of highly toxic compounds. The treatment of OP intoxication is, however,…”
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Tetroxime: reactivation potency - in vitro and in silico study by Kuca, K, Korabecny, J, Dolezal, R, Nepovimova, E, Soukup, O, Gorecki, L, Musilek, K

“…Acetylcholinesterase (AChE) reactivators (oximes) are generally used as treatment in cases of nerve agent poisoning. There is no single oxime applicable in…”
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Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity by Janockova, J, Zilecka, E, Kasparkova, J, Brabec, V, Soukup, O, Kuca, K, Kozurkova, M

“…In this paper, we describe the biochemical properties and biological activity of a series of cholinesterase reactivators (symmetrical bisquaternary…”
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The Effect of Chemical Structure of OEG Ligand Shells with Quaternary Ammonium Moiety on the Colloidal Stabilization, Cellular Uptake and Photothermal Stability of Gold Nanorods by Salajkova, Sarka, Havel, Filip, Sramek, Michal, Novotny, Filip, Malinak, David, Dolezal, Rafael, Prchal, Lukas, Benkova, Marketa, Soukup, Ondrej, Musilek, Kamil, Kuca, Kamil, Bartek, Jiri, Proska, Jan, Zarska, Monika, Hodny, Zdenek

“…Plasmonic photothermal cancer therapy by gold nanorods (GNRs) emerges as a promising tool for cancer treatment. The goal of this study was to design cationic…”
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Interaction of nerve agent antidotes with cholinergic systems by Soukup, O, Tobin, G, Kumar, U K, Binder, J, Proska, J, Jun, D, Fusek, J, Kuca, K

“…The poisoning with organophosphorus compounds represents a life threatening danger especially in the time of terroristic menace. No universal antidote has been…”
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A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication by Nepovimova, E, Korabecny, J, Dolezal, R, Nguyen, T D, Jun, D, Soukup, O, Pasdiorova, M, Jost, P, Muckova, L, Malinak, D, Gorecki, L, Musilek, K, Kuca, Kamil

“…Chemical warfare agents constitute an increasing threat to both military and civilian populations. Therefore, effective prophylactic approaches are urgently…”
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The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers by Soukup, O., Kristofikova, Z., Jun, D., Tambor, V., Ripova, D., Kuca, K.

“…► We investigated non-reactivating properties of standard oxime reactivators. ► We report their effect on hemicholinium-3 sensitive carriers. ► We show…”
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The effect of oxime reactivators on muscarinic receptors: Functional and binding examinations by Soukup, O, Kumar, U.K, Proska, J, Bratova, L, Adem, A, Jun, D, Fusek, J, Kuca, K, Tobin, G

“…Abstract The antidotal treatment of organophosphorus poisoning is still a problematic issue since no versatile antidote has been developed yet. In our study,…”
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The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor by Sepsova, V, Krusek, J, Zdarova Karasova, J, Zemek, F, Musilek, K, Kuca, K, Soukup, O

“…Acetylcholinesterase inhibitors (AChEIs) are used in the treatment of myasthenia gravis (MG). We investigated the effects of AChEIs on peripheral nicotinic…”
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Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors by Soukup, O, Krůšek, J, Kaniaková, M, Kumar, U K, Oz, M, Jun, D, Fusek, J, Kuča, K, Tobin, G

“…Current treatment of organophosphorus poisoning, resulting in overstimulation and desensitization of muscarinic and nicotinic receptors by acetylcholine (ACh),…”
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Novel acetylcholinesterase reactivator K112 and its cholinergic properties by Soukup, O, Kristofikova, Z, Proska, J, Tobin, G, Patocka, J, Marek, J, Jun, D, Fusek, J, Ripova, D, Kuca, K

“…Abstract The oxime reactivator K112 is a member of the new group of xylene linker-containing AChE reactivators. Its cholinergic properties could be of…”
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Pralidoxime--the gold standard of acetylcholinesterase reactivators--reactivation in vitro efficacy by Kuca, K, Hrabinova, M, Soukup, O, Tobin, G, Karasova, J, Pohanka, M

“…In this work, we aim to summarize the universality of this compound, its reactivation potential when different cholinesterase inhibitors are used. Pralidoxime…”
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7-methoxyderivative of tacrine is a potent open channel blocker of NMDA receptors by Horak, M., Kaniakova, M., Soukup, O., Korabecny, J.

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Non-peptide orexin 2 receptor modulators as promising way to treatment of narcolepsy/insomnia by Janockova, J., Kobrlova, T., Mezeiova, E., Dolezal, R., Korabecny, J., Soukup, O.

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P.525 Tacrine derivatives as potent inhibitors of N-methyl-D-aspartate receptors with neuroprotective activity by Horak, M., Kaniakova, M., Soukup, O., Korabecny, J., Kleteckova, L., Vales, K.

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Tacrine First-Phase Biotransformation and Associated Hepatotoxicity: A Possible Way to Avoid Quinone Methide Formation by Novak, Martin, Vajrychova, Marie, Koutsilieri, Stefania, Sismanoglou, Despoina-Christina, Kobrlova, Tereza, Prchal, Lukas, Svobodova, Barbora, Korabecny, Jan, Zarybnicky, Tomas, Raisova-Stuchlikova, Lucie, Skalova, Lenka, Lauschke, Volker M., Kučera, Radim, Soukup, Ondrej

“…Tacrine was withdrawn from clinical use as a drug against Alzheimer’s disease in 2013, mainly due to drug-induced liver injury. The culprit of…”
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Tacrine - tryptophan derivatives – novel agents against the Alzheimer’s disease by Soukup, O., Korabecny, J., Nepovimova, E., Karasova-Zdarova, J., Vales, K., Ricny, J., Jun, D., Kuca, K.

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