Search Results - "Sottini, Andrea"
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Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexes
Published in Nature communications (12-11-2020)“…Highly charged intrinsically disordered proteins can form complexes with very high affinity in which both binding partners fully retain their disorder and…”
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2
Binding without folding – the biomolecular function of disordered polyelectrolyte complexes
Published in Current opinion in structural biology (01-02-2020)“…[Display omitted] •Highly charged intrinsically disordered proteins can form high-affinity complexes without gain of structure or site-specific…”
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Author Correction: Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexes
Published in Nature communications (21-09-2023)Get full text
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4
Cavitand-Grafted Silicon Microcantilevers as a Universal Probe for Illicit and Designer Drugs in Water
Published in Angewandte Chemie International Edition (25-08-2014)“…The direct, clean, and unbiased transduction of molecular recognition into a readable and reproducible response is the biggest challenge associated to the use…”
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Social entrepreneurship and social innovation: A bibliometric review and research agenda
Published in European management journal (01-04-2024)“…Despite the increasing focus on scientific maturity in social entrepreneurship (SE) and social innovation (SI), scholars still place a greater focus on…”
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Extreme dynamics in a biomolecular condensate
Published in Nature (London) (27-07-2023)“…Proteins and nucleic acids can phase-separate in the cell to form concentrated biomolecular condensates 1 – 4 . The functions of condensates span many length…”
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Extreme disorder in an ultrahigh-affinity protein complex
Published in Nature (London) (01-03-2018)“…Molecular communication in biology is mediated by protein interactions. According to the current paradigm, the specificity and affinity required for these…”
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8
Engaging symbiotic ecosystems to build community centred business models for the BoP: Evidence from small social enterprises in East Africa
Published in International small business journal (01-12-2022)“…This article examines how small social enterprises (SSEs) in East Africa build business models for base of the pyramid (BoP) markets, through engaging…”
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9
Rapid droplet-based mixing for single-molecule spectroscopy
Published in Nature methods (01-10-2023)“…Probing non-equilibrium dynamics with single-molecule spectroscopy is important for dissecting biomolecular mechanisms. However, existing microfluidic…”
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10
Single molecule reaction-diffusion with single photon FCS-FRET
Published in Biophysical journal (11-02-2022)Get full text
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11
Entrepreneurship and misconducting behaviors: A conceptual model of institutional divergence
Published in International journal of entrepreneurship and innovation (01-11-2023)“…Over the last decades, scholars considered entrepreneurship as synonymous with thinking “outside of the box” and breaking the status quo. In this view,…”
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Polyelectrolyte complexation of charged IDPs driven by the entropy of counterion release
Published in Biophysical journal (11-02-2022)Get full text
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13
Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein
Published in Nature chemistry (01-02-2022)“…Highly charged intrinsically disordered proteins are essential regulators of chromatin structure and transcriptional activity. Here we identify a surprising…”
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Elucidating the dynamics of individual IDPs in a biomolecular condensate using single-molecule FRET and molecular simulation
Published in Biophysical journal (10-02-2023)Get full text
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15
Thermodynamics of the Interaction between Biological Polyelectrolyte-Like Disordered Proteins: From Binary Complexes to Oligomers
Published in Biophysical journal (07-02-2020)Get full text
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Molecular Origins of Free Energies Associated with Complex Interactions of Biological Polyelectrolyte-Like Disordered Proteins
Published in Biophysical journal (12-02-2021)Get full text
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Driving forces of the complex formation between highly charged disordered proteins
Published in Proceedings of the National Academy of Sciences - PNAS (10-10-2023)“…Highly disordered complexes between oppositely charged intrinsically disordered proteins present a new paradigm of biomolecular interactions. Here, we…”
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Complete description of rapid single-molecule dynamics beyond instrument acquisition rate
Published in Biophysical journal (11-02-2022)Get full text
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Complexes of charged disordered polyelectrolyte-like proteins: From thermodynamics to stuctural plasticity
Published in Biophysical journal (10-02-2023)Get full text
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20
Extreme disorder in an ultra-high-affinity protein complex
Published in Nature (London) (21-02-2018)“…Molecular communication in biology is mediated by protein interactions. According to the current paradigm, the specificity and affinity required for these…”
Get full text
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