Search Results - "Sottile, Mayra L"

Heat shock proteins and DNA repair mechanisms: an updated overview by Sottile, Mayra L., Nadin, Silvina B.

“…Heat shock proteins (HSPs), also known as molecular chaperones, participate in important cellular processes, such as protein aggregation, disaggregation,…”
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Relevance of Comet Assay and Phosphorylated-Hsp90α in Cancer Patients’ Peripheral Blood Leukocytes as Tools to Assess Cisplatin-based Chemotherapy Clinical Response and Disease Outcome by Sottile, Mayra L., Gómez, Laura C., Redondo, Analía, Ibarra, Jorge, García, María B., Gonzalez, Lucía, Vargas-Roig, Laura M., Nadin, Silvina B.

“…Cisplatin (cPt) is a commonly used treatment for solid tumors. The main target of its cytotoxicity is the DNA molecule, which makes the DNA damage response…”
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Circulating heat shock protein 27 (HSPB1) levels in prediction of pre‐eclampsia: A pilot study by Martin, Raquel L., Sottile, Mayra L., Redondo, Analia L., Gomez, Laura C., Gauna, Gisel V., Flamini, Marina I., Grajeda, Carina, Anzalone, Alfonsa C., Rodriguez‐Echandia, Eduardo, Nadin, Silvina B., Vargas‐Roig, Laura M.

“…Objective To determine whether circulating heat shock proteins HSP27/HSPB1 and HSP90α/HSPC1 may be useful for early prediction of the occurrence of…”
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DNA Damage Repair Proteins, HSP27, and Phosphorylated-HSP90α as Predictive/Prognostic Biomarkers of Platinum-based Cancer Chemotherapy: An Exploratory Study by Sottile, Mayra L., Cuello-Carrión, Fernando D., Gómez, Laura C., Semino, Silvana, Ibarra, Jorge, García, María B., Gonzalez, Lucía, Vargas-Roig, Laura M., Nadin, Silvina B.

“…Platinum analogs are commonly used for cancer treatment. There is increasing interest in finding biomarkers which could predict and overcome resistance,…”
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Double heterozygous pathogenic variants in the BRCA1 and BRCA2 genes in a patient with bilateral metachronous breast cancer by Mampel, Alejandra, Sottile, Mayra L., Denita-Juárez, Silvina P., Vargas, Ana L., Vargas-Roig, Laura M.

“…Double heterozygosity pathogenic variants in BRCA1 and BRCA2 genes are a very rare finding, particularly in non-Ashkenazi individuals. We described the first…”
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TP73 DNA methylation and upregulation of ΔNp73 are associated with an adverse prognosis in breast cancer by Gomez, Laura C, Sottile, Mayra L, Guerrero-Gimenez, Martin E, Zoppino, Felipe C M, Redondo, Analia L, Gago, Francisco E, Orozco, Javier I, Tello, Olga M, Roqué, Maria, Nadin, Silvina B, Marzese, Diego M, Vargas-Roig, Laura M

“…Accumulated evidence suggests that aberrant methylation of the gene and increased levels of ΔNp73 in primary tumours correlate with poor prognosis. However,…”
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Hyperthermia effects on Hsp27 and Hsp72 associations with mismatch repair (MMR) proteins and cisplatin toxicity in MMR-deficient/proficient colon cancer cell lines by Sottile, Mayra L, Losinno, Antonella D, Fanelli, Mariel A, Cuello-Carrión, F Darío, Montt-Guevara, M Magdalena, Vargas-Roig, Laura M, Nadin, Silvina B

“…Hyperthermia is used in combination with conventional anticancer agents to potentiate their cytotoxicity. One of its key events is the synthesis of heat shock…”
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Prognostic implication of HSPA (HSP70) in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy by Nadin, Silvina B., Sottile, Mayra L., Montt-Guevara, Maria M., Gauna, Gisel V., Daguerre, Pedro, Leuzzi, Marcela, Gago, Francisco E., Ibarra, Jorge, Cuello-Carrión, F. Darío, Ciocca, Daniel R., Vargas-Roig, Laura M.

“…Neoadjuvant chemotherapy is used in patients with locally advanced breast cancer to reduce tumor size before surgery. Unfortunately, resistance to chemotherapy…”
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Effects of hyperthermia on Hsp27 (HSPB1), Hsp72 (HSPA1A) and DNA repair proteins hMLH1 and hMSH2 in human colorectal cancer hMLH1-deficient and hMLH1-proficient cell lines by Nadin, Silvina B, Cuello-Carrión, F Darío, Sottile, Mayra L, Ciocca, Daniel R, Vargas-Roig, Laura M

“…The objective of the present study was to examine the consequences of a mild hyperthermia in human tumour cell lines deficient and proficient in the DNA…”
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DNA Damage Repair Proteins, HSP27, and Phosphorylated-HSP90α as Predictive/Prognostic Biomarkers of Platinum-based Cancer Chemotherapy: An Exploratory Study by Sottile, Mayra L., Cuello-Carrión, Fernando D., Gómez, Laura C., Semino, Silvana, Ibarra, Jorge, García, María B., Gonzalez, Lucía, Vargas-Roig, Laura M., Nadin, Silvina B.

“…Platinum analogs are commonly used for cancer treatment. There is increasing interest in finding biomarkers which could predict and overcome resistance,…”
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