Search Results - "Sottas, Chantal M."

Identification, Proliferation, and Differentiation of Adult Leydig Stem Cells by Stanley, Erin, Lin, Chieh-Yin, Jin, Shiying, Liu, June, Sottas, Chantal M, Ge, Renshan, Zirkin, Barry R, Chen, Haolin

“…Leydig cells, the testosterone-producing cells of the adult testis, rarely turn over. However, their elimination with ethane dimethanesulfonate (EDS) is…”
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In Search of Rat Stem Leydig Cells: Identification, Isolation, and Lineage-Specific Development by Ge, Ren-Shan, Dong, Qiang, Sottas, Chantal M., Papadopoulos, Vassilios, Zirkin, Barry R., Hardy, Matthew P.

“…Leydig cells (LCs) are thought to differentiate from spindle-shaped precursor cells that exhibit some aspects of differentiated function, including…”
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Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero by Lin, Han, Ge, Ren-Shan, Chen, Guo-Rong, Hu, Guo-Xin, Dong, Lei, Lian, Qing-Quan, Hardy, Dianne O, Sottas, Chantal M, Li, Xiao-Kun, Hardy, Matthew P

“…Exposures to di-(2-ethylhexyl) phthalate (DEHP) have been shown to be associated with decreased adult testosterone (T) levels and increased Leydig cell…”
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Mono-(2-ethylhexyl) phthalate affects the steroidogenesis in rat Leydig cells through provoking ROS perturbation by Zhao, Yan, Ao, Hong, Chen, Li, Sottas, Chantal M., Ge, Ren-shan, Li, Luxi, Zhang, Yunhui

“…► We explored the effect of MEHP on androgen production of rat Leydig cells. ► Low levels of MEHP increased androgen production. ► High levels of MEHP…”
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SARS-CoV-2 Enters Human Leydig Cells and Affects Testosterone Production In Vitro by Li, Lu, Sottas, Chantal M, Chen, Hsu-Yu, Li, Yuchang, Cui, Haoyi, Villano, Jason S, Mankowski, Joseph L, Cannon, Paula M, Papadopoulos, Vassilios

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a SARS-like coronavirus, continues to produce mounting infections and fatalities all over the…”
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Alterations of gene profiles in Leydig-cell-regenerating adult rat testis after ethane dimethane sulfonate-treatment by Zhang, Yu-Fei, Yuan, Kai-Ming, Liang, Yong, Chu, Yan-Hui, Lian, Qing-Quan, Ge, Yu-Fei, Zhen, Wei, Sottas, Chantal M, Su, Zhi-Jian, Ge, Ren-Shan

“…Only occupying about 1%-5% of total testicular cells, the adult Leydig cell (ALC) is a unique endocrine cell that produces androgens. Rat Leydig cells…”
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In Utero and Lactational Exposures to Diethylhexyl-Phthalate Affect Two Populations of Leydig Cells in Male Long-Evans Rats by Lin, Han, Lian, Qing-Quan, Hu, Guo-Xin, Jin, Yuan, Zhang, Yunhui, Hardy, Dianne O, Chen, Guo-Rong, Lu, Zhong-Qiu, Sottas, Chantal M, Hardy, Matthew P, Ge, Ren-Shan

“…Diethylhexylphthalate (DEHP) has been classified as an antiandrogen. However, whether in utero and lactational exposures of DEHP affect Leydig cells has not…”
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Gene Expression During Development of Fetal and Adult Leydig Cells by DONG, LEI, JELINSKY, SCOTT A., FINGER, JOSHUA N., JOHNSTON, DANIEL S., KOPF, GREGORY S., SOTTAS, CHANTAL M., HARDY, MATTHEW P., GE, REN-SHAN

“…: In rats and mice, Leydig cells are formed as two morphologically and functionally different generations. The first generation develops in utero, from…”
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Biphasic Effects of Postnatal Exposure to Diethylhexylphthalate on the Timing of Puberty in Male Rats by Ge, Ren-Shan, Chen, Guo-Rong, Dong, Qiang, Akingbemi, Benson, Sottas, Chantal M, Santos, Michelle, Sealfon, Stuart C, Bernard, Daniel J, Hardy, Matthew P

“…Phthalate esters such as di(2‐ethylhexyl)phthalate (DEHP), which are commonly found in cosmetics and in flexible plastics distributed by the food,…”
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A Role for Kit Receptor Signaling in Leydig Cell Steroidogenesis by ROTHSCHILD, Gerson, SOTTAS, Chantal M, KISSEL, Holger, AGOSTI, Valter, MANOVA, Katia, HARDY, Matthew P, BESMER, Peter

“…Kit and its ligand, Kitl, function in hematopoiesis, melanogenesis, and gametogenesis. In the testis, Kitl is expressed by Sertoli cells and Kit is expressed…”
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Trends of Reproductive Hormones in Male Rats During Psychosocial Stress: Role of Glucocorticoid Metabolism in Behavioral Dominance by Hardy, Matthew P, Sottas, Chantal M, Ge, Renshan, McKittrick, Christina R, Tamashiro, Kellie L, McEwen, Bruce S, Haider, Syed G, Markham, Christopher M, Blanchard, Robert J, Blanchard, D Caroline, Sakai, Randall R

“…Stress in socially subordinate male rats, associated with aggressive attacks by dominant males, was studied in a group-housing context called the visible…”
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Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated by Ge, Ren-Shan, Dong, Qiang, Sottas, Chantal M., Latif, Syed A., Morris, David J., Hardy, Matthew P.

“…The testis is known to be a site of corticosterone action, and testosterone production in Leydig cells is directly inhibited by glucocorticoids…”
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Increased Proliferation but Decreased Steroidogenic Capacity in Leydig Cells from Mice Lacking Cyclin-Dependent Kinase Inhibitor 1B by Lin, Han, Hu, Guo-Xin, Dong, Lei, Dong, Qiang, Mukai, Motoko, Chen, Bing-Bing, Holsberger, Denise R, Sottas, Chantal M, Cooke, Paul S, Lian, Qing-Quan, Li, Xiao-Kun, Ge, Ren-Shan

“…Proliferating cells express cyclins, cell cycle regulatory proteins that regulate the activity of cyclin-dependent kinases (CDKs). The actions of CDKs are…”
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Increased Proliferation but Decreased Steroidogenic Capacity in Leydig Cells from Mice Lacking Cyclin-Dependent Kinase Inhibitor 1B1 by Lin, Han, Hu, Guo-Xin, Dong, Lei, Dong, Qiang, Mukai, Motoko, Chen, Bing-Bing, Holsberger, Denise R, Sottas, Chantal M, Cooke, Paul S, Lian, Qing-Quan, Li, Xiao-Kun, Ge, Ren-Shan

“…Proliferating cells express cyclins, cell cycle regulatory proteins that regulate the activity of cyclin-dependent kinases (CDKs). The actions of CDKs are…”
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Rapid Glucocorticoid Mediation of Suppressed Testosterone Biosynthesis in Male Mice Subjected to Immobilization Stress by Dong, Qiang, Salva, Antonio, Sottas, Chantal M, Niu, Enmei, Holmes, Michael, Hardy, Matthew P

“…Physical and psychosocial stress challenge homeostasis, increasing glucocorticoid secretion (in rodents, corticosterone [CORT]) while decreasing testosterone…”
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Inhibition of Testicular Steroidogenesis by the Xenoestrogen Bisphenol A Is Associated with Reduced Pituitary Luteinizing Hormone Secretion and Decreased Steroidogenic Enzyme Gene Expression in Rat Leydig Cells by Akingbemi, Benson T, Sottas, Chantal M, Koulova, Anna I, Klinefelter, Gary R, Hardy, Matthew P

“…Exposure of humans to bisphenol A (BPA), a monomer in polycarbonate plastics and a constituent of resins used in food packaging and dentistry, is significant…”
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In Utero and Lactational Exposures to Diethylhexyl-Phthalate Affect Two Populations of Leydig Cells in Male Long-Evans Rats1 by Lin, Han, Lian, Qing-Quan, Hu, Guo-Xin, Jin, Yuan, Zhang, Yunhui, Hardy, Dianne O, Chen, Guo-Rong, Lu, Zhong-Qiu, Sottas, Chantal M, Hardy, Matthew P, Ge, Ren-Shan

“…Diethylhexylphthalate (DEHP) has been classified as an antiandrogen. However, whether in utero and lactational exposures of DEHP affect Leydig cells has not…”
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Paracrine Modulation of Androgen Synthesis in Rat Leydig Cells by Nitric Oxide by Weissman, Ben A, Niu, Enmei, Ge, Renshan, Sottas, Chantal M, Holmes, Michael, Hutson, James C, Hardy, Matthew P

“…The free radical nitric oxide (NO), generated through the oxidation of l‐arginine to l‐citrulline by NO synthases (NOSs), has been shown to inhibit…”
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Gene Expression in Rat Leydig Cells During Development from the Progenitor to Adult Stage: A Cluster Analysis by GE, Ren-Shan, QIANG DONG, SOTTAS, Chantal M, HAOLIN CHEN, ZIRKIN, Barry R, HARDY, Matthew P

“…The postnatal development of Leydig cells can be divided into three distinct stages: initially they exist as fibroblast-like progenitor Leydig cells (PLCs)…”
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Effect of brominated flame retardant BDE-47 on androgen production of adult rat Leydig cells by Zhao, Yan, Ao, Hong, Chen, Li, Sottas, Chantal M., Ge, Ren-Shan, Zhang, Yunhui

“…► We explored the effect of BDE-47 on androgen production of Leydig cells. ► Low dose BDE-47 increased testosterone at a dose-dependent manner. ► StAR, cAMP…”
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