Search Results - "Sotolongo, John"

Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis‐associated tumorigenesis by Fukata, Masayuki, Shang, Limin, Santaolalla, Rebeca, Sotolongo, John, Pastorini, Cristhine, España, Cecilia, Ungaro, Ryan, Harpaz, Noam, Cooper, Harry S, Elson, Greg, Kosco‐Vilbois, Marie, Zaias, Julia, Perez, Maria T., Mayer, Lloyd, Vamadevan, Arunan S., Lira, Sergio A., Abreu, Maria T.

“…Background: Chronic intestinal inflammation culminates in cancer and a link to Toll‐like receptor‐4 (TLR4) has been suggested by our observation that TLR4…”
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A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis by Ungaro, Ryan, Fukata, Masayuki, Hsu, David, Hernandez, Yasmin, Breglio, Keith, Chen, Anli, Xu, Ruliang, Sotolongo, John, Espana, Cecillia, Zaias, Julia, Elson, Greg, Mayer, Lloyd, Kosco-Vilbois, Marie, Abreu, Maria T

“…Dysregulated innate immune responses to commensal bacteria contribute to the development of inflammatory bowel disease (IBD). TLR4 is overexpressed in the…”
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TLR4 activates the β-catenin pathway to cause intestinal neoplasia by Santaolalla, Rebeca, Sussman, Daniel A, Ruiz, Jose R, Davies, Julie M, Pastorini, Cristhine, España, Cecilia L, Sotolongo, John, Burlingame, Oname, Bejarano, Pablo A, Philip, Sakhi, Ahmed, Mansoor M, Ko, Jeffrey, Dirisina, Ramanarao, Barrett, Terrence A, Shang, Limin, Lira, Sergio A, Fukata, Masayuki, Abreu, Maria T

“…Colonic bacteria have been implicated in the development of colon cancer. We have previously demonstrated that toll-like receptor 4 (TLR4), the receptor for…”
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Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury by Hsu, David, Fukata, Masayuki, Hernandez, Yasmin G, Sotolongo, John P, Goo, Tyralee, Maki, Junsuke, Hayes, Lory A, Ungaro, Ryan C, Chen, Anli, Breglio, Keith J, Xu, Ruliang, Abreu, Maria T

“…Epiregulin (EPI) and amphiregulin (AR) are epidermal growth factor receptor (EGFR) ligands implicated in mucosal repair and tumorigenesis. We have shown that…”
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Human Intestinal Epithelial Cells Express Interleukin-10 through Toll-Like Receptor 4-Mediated Epithelial-Macrophage Crosstalk by Hyun, Jinhee, Romero, Laura, Riveron, Reldy, Flores, Claudia, Kanagavelu, Saravana, Chung, Kristina D., Alonso, Ana, Sotolongo, John, Ruiz, Jose, Manukyan, Armine, Chun, Sally, Singh, Gaurav, Salas, Pedro, Targan, Stephan R., Fukata, Masayuki

“…In the intestine, interaction between epithelial cells and macrophages (MΦs) create a unique immunoregulatory microenvironment necessary to maintain local…”
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The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia by Hernandez, Yasmin, Sotolongo, John, Breglio, Keith, Conduah, Daisy, Chen, Anli, Xu, Ruliang, Hsu, David, Ungaro, Ryan, Hayes, Lory A, Pastorini, Cristhine, Abreu, Maria T, Fukata, Masayuki

“…We have previously found that TLR4-deficient (TLR4-/-) mice demonstrate decreased expression of mucosal PGE 2 and are protected against colitis-associated…”
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Intestinal Mucosal Defense Against Invasion of Gram-Negative Bacteria Requires TRIF-Mediated Amplification of IFNs in the Mesenteric Lymph Node (MLN) by Sotolongo, John P, Espana, Cecilia, Zaias, Julia, Santaolalla, Rebeca, Ruiz, Jose, Fukata, Masayuki

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Toll-Like Receptor4 (TLR4) Signaling Contribute to Immunomodulation Through Epithelial Peroxisome Proliferator-Activated Receptor (PPARγ) Activation During Intestinal Inflammation by Sotolongo, John P, Espana, Cecilia, Zaias, Julia, Santaolalla, Rebeca, Ruiz, Jose, Fukata, Masayuki

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TRIF mobilizes unique primary defense against Gram-negative bacteria in intestinal interface by Sotolongo, John, Kanagavelu, Saravana, Hyun, Jinhee, Ruiz, Jose, Fukata, Masayuki

“…The gastrointestinal tract is the largest mucosal surface in our body. It houses diverse microorganisms that collectively form the commensal microbial…”
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M1820 Activated Toll-Like Receptor 4 (TLR4) Directs Differentiation of Goblet and Paneth Cells by Pastorini, Cristhine, Santaolalla, Rebeca, Fukata, Masayuki, Sotolongo, John P, Espana, Cecilia, Hayes, Lory, Abreu, Maria T

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M1776 Toll-Like Receptor 4 (TLR4) is a Target of Wnt/β-Catenin Signaling in Intestinal Epithelial Cells (IEC): Implications for Sporadic Colon Cancer by Vamadevan, Arunan S, Fukata, Masayuki, Sotolongo, John P, Espana, Cecilia, Santaolalla, Rebeca, Hayes, Lory, Abreu, Maria T

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M1800 Impaired Autophagy: A Mechanism for Loss of Response to Anti-TNFS by Santaolalla, Rebeca, Pastorini, Cristhine, Fukata, Masayuki, Sotolongo, John P, Espana, Cecilia, Hayes, Lory, Abreu, Maria T

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TLR4 Signaling Activates the Wnt Pathway and Promotes Neoplasia by Santaolalla, Rebeca, Ruiz, Jose, Pastorini, Cristhine, Fukata, Masayuki, Espana, Cecilia, Sotolongo, John P, Sussman, Daniel A, Ko, Jeffrey Z, Dirisina, Ramanarao V, Barrett, Terrence A, Abreu, Maria T

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M1946 A Toll-Like Receptor 4 (TLR4) Antibody Antagonist Can Prevent Colitis-Associated Neoplasia by Fukata, Masayuki, Espana, Cecilia, Ungaro, Ryan, Sotolongo, John P, Pastorini, Cristhine, Altman, Norman, Zaias, Julia, Vamadevan, Arunan S, Santaolalla, Rebeca, Elson, Greg, Kosco-Vilbois, Marie, Hayes, Lory, Abreu, Maria T

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586 Toll-Like Receptor 3 (TLR3) Signaling Improves Intestinal Mucosal Defense Against Pathogens by Sotolongo, John P, Echeverry, Andrea, Espana, Cecilia, Adkins, Rebecca, Vamadevan, Arunan S, Hayes, Lory, Zaias, Julia, Fukata, Masayuki

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574 Transgenic Epithelial Expression of TLR4 Results in Duodenal Adenoma and Colitis-Associated Neoplasia by Fukata, Masayuki, Shang, Limin, Hernandez, Yasmin, Breglio, Keith J, Harpaz, Noam, Cooper, Harry S, Sotolongo, John P, Hayes, Lory, Ungaro, Ryan, Dahan, Stephanie, Lira, Sergio A, Abreu, Maria T

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Host innate recognition of an intestinal bacterial pathogen induces TRIF-dependent protective immunity by Sotolongo, John, España, Cecilia, Echeverry, Andrea, Siefker, David, Altman, Norman, Zaias, Julia, Santaolalla, Rebeca, Ruiz, Jose, Schesser, Kurt, Adkins, Becky, Fukata, Masayuki

“…Toll-like receptor 4 (TLR4), which signals through the adapter molecules myeloid differentiation factor 88 (MyD88) and toll/interleukin 1 receptor…”
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The Role of Innate Immunity in the Host Defense Against Intestinal Bacterial Pathogens by Sotolongo, John, Ruiz, Jose, Fukata, Masayuki

“…Eradication of infectious disease is our global health challenge. After encountering intestinal infection with a bacterial pathogen, the host defense program…”
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Toll-like receptor 4 signaling integrates intestinal inflammation with tumorigenesis: lessons from the murine model of colitis-associated cancer by Hernandez, Yasmin, Sotolongo, John, Fukata, Masayuki

“…Chronic inflammation has long been implicated as a predisposition for cancer, but the underlying mechanism for how this occurs has remained obscure. Ulcerative…”
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TLR4 Activates the [beta]-catenin Pathway to Cause Intestinal Neoplasia by Santaolalla, Rebeca, Sussman, Daniel A, Ruiz, Jose R, Davies, Julie M, Pastorini, Cristhine, España, Cecilia L, Sotolongo, John, Burlingame, Oname, Bejarano, Pablo A, Philip, Sakhi, Ahmed, Mansoor M, Ko, Jeffrey, Dirisina, Ramanarao, Barrett, Terrence A, Shang, Limin, Lira, Sergio A, Fukata, Masayuki, Abreu, Maria T

“…Colonic bacteria have been implicated in the development of colon cancer. We have previously demonstrated that toll-like receptor 4 (TLR4), the receptor for…”
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