Search Results - "Sotocinal, Susana"

The assessment of post-vasectomy pain in mice using behaviour and the Mouse Grimace Scale by Leach, Matthew C, Klaus, Kristel, Miller, Amy L, Scotto di Perrotolo, Maud, Sotocinal, Susana G, Flecknell, Paul A

“…Current behaviour-based pain assessments for laboratory rodents have significant limitations. Assessment of facial expression changes, as a novel means of pain…”
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The Rat Grimace Scale: A Partially Automated Method for Quantifying Pain in the Laboratory Rat via Facial Expressions by Sotocina, Susana G, Sorge, Robert E, Zaloum, Austin, Tuttle, Alexander H, Martin, Loren J, Wieskopf, Jeffrey S, Mapplebeck, Josiane CS, Wei, Peng, Zhan, Shu, Zhang, Shuren, McDougall, Jason J, King, Oliver D, Mogil, Jeffrey S

“…We recently demonstrated the utility of quantifying spontaneous pain in mice via the blinded coding of facial expressions. As the majority of preclinical pain…”
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Different immune cells mediate mechanical pain hypersensitivity in male and female mice by Sorge, Robert E, Mapplebeck, Josiane C S, Rosen, Sarah, Beggs, Simon, Taves, Sarah, Alexander, Jessica K, Martin, Loren J, Austin, Jean-Sebastien, Sotocinal, Susana G, Chen, Di, Yang, Mu, Shi, Xiang Qun, Huang, Hao, Pillon, Nicolas J, Bilan, Philip J, Tu, YuShan, Klip, Amira, Ji, Ru-Rong, Zhang, Ji, Salter, Michael W, Mogil, Jeffrey S

“…A large literature has demonstrated the important role of spinal microglia in chronic pain processing. This paper demonstrates that microglia are required in…”
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Monoaminergic mediation of hyperalgesic and analgesic descending control of nociception in mice by Nemoto, Wataru, Kozak, Dalia, Sotocinal, Susana G., Tansley, Shannon, Bannister, Kirsty, Mogil, Jeffrey S.

“…Descending control of nociception (DCN; also known as conditioned pain modulation [CPM], the behavioral correlate of diffuse noxious inhibitory controls) is…”
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Sex-specific effects of neuropathic pain on long-term pain behavior and mortality in mice by Millecamps, Magali, Sotocinal, Susana G., Austin, Jean-Sebastien, Stone, Laura S., Mogil, Jeffrey S.

“…Human epidemiological studies suggest that chronic pain can increase mortality risk. We investigated whether this was true in mice so that underlying…”
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A deep neural network to assess spontaneous pain from mouse facial expressions by Tuttle, Alexander H, Molinaro, Mark J, Jethwa, Jasmine F, Sotocinal, Susana G, Prieto, Juan C, Styner, Martin A, Mogil, Jeffrey S, Zylka, Mark J

“…Grimace scales quantify characteristic facial expressions associated with spontaneous pain in rodents and other mammals. However, these scales have not been…”
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Coding of facial expressions of pain in the laboratory mouse by Glick, Sarah, Sotocinal, Susana G, Chanda, Mona Lisa, Echols, Stephanie, Bailey, Andrea L, Wong, David, Mogil, Jeffrey S, Matsumiya, Lynn, LaCroix-Fralish, Michael L, van den Maagdenberg, Arn M J M, Ferrari, Michel D, Klassen-Ross, Tammy, Clarke, Sarah E, Craig, Kenneth D, Drummond, Tanya E, Sorge, Robert E, Tabaka, John M, Langford, Dale J, Ingrao, Joelle

“…Facial expression is widely used as a measure of pain in infants; whether nonhuman animals display such pain expressions has never been systematically…”
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Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice by Sorge, Robert E, LaCroix-Fralish, Michael L, Tuttle, Alexander H, Sotocinal, Susana G, Austin, Jean-Sebastien, Ritchie, Jennifer, Chanda, Mona Lisa, Graham, Allyson C, Topham, Lucas, Beggs, Simon, Salter, Michael W, Mogil, Jeffrey S

“…The innate immune system is increasingly appreciated to play an important role in the mediation of chronic pain, and one molecule implicated in this process is…”
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Olfactory exposure to males, including men, causes stress and related analgesia in rodents by Sorge, Robert E, Martin, Loren J, Isbester, Kelsey A, Sotocinal, Susana G, Rosen, Sarah, Tuttle, Alexander H, Wieskopf, Jeffrey S, Acland, Erinn L, Dokova, Anastassia, Kadoura, Basil, Leger, Philip, Mapplebeck, Josiane C S, McPhail, Martina, Delaney, Ada, Wigerblad, Gustaf, Schumann, Alan P, Quinn, Tammie, Frasnelli, Johannes, Svensson, Camilla I, Sternberg, Wendy F, Mogil, Jeffrey S

“…The presence of male experimenters induces stress and stress-induced analgesia, affecting behavioral assays in mice. We found that exposure of mice and rats to…”
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Social Modulation of Pain as Evidence for Empathy in Mice by Langford, Dale J, Crager, Sara E, Shehzad, Zarrar, Smith, Shad B, Sotocinal, Susana G, Levenstadt, Jeremy S, Chanda, Mona Lisa, Levitin, Daniel J, Mogil, Jeffrey S

“…Empathy is thought to be unique to higher primates, possibly to humans alone. We report the modulation of pain sensitivity in mice produced solely by exposure…”
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Increased pain sensitivity and decreased opioid analgesia in T-cell-deficient mice and implications for sex differences by Rosen, Sarah F., Ham, Boram, Haichin, Michael, Walters, Ilana C., Tohyama, Sarasa, Sotocinal, Susana G., Mogil, Jeffrey S.

“…The processing of pain in the central nervous system is now known to have an important immune component, including T cells of the adaptive immune system. T…”
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Recruitment of Spinoparabrachial Neurons by Dorsal Horn Calretinin Neurons by Petitjean, Hugues, Bourojeni, Farin B., Tsao, Deborah, Davidova, Albena, Sotocinal, Susana G., Mogil, Jeffrey S., Kania, Artur, Sharif-Naeini, Reza

“…The dorsal horn of the spinal cord is the first integration site of somatosensory inputs from the periphery. In the superficial layers of the dorsal horn,…”
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Epiregulin and EGFR interactions are involved in pain processing by Martin, Loren J, Smith, Shad B, Khoutorsky, Arkady, Magnussen, Claire A, Samoshkin, Alexander, Sorge, Robert E, Cho, Chulmin, Yosefpour, Noosha, Sivaselvachandran, Sivaani, Tohyama, Sarasa, Cole, Tiffany, Khuong, Thang M, Mir, Ellen, Gibson, Dustin G, Wieskopf, Jeffrey S, Sotocinal, Susana G, Austin, Jean Sebastien, Meloto, Carolina B, Gitt, Joseph H, Gkogkas, Christos, Sonenberg, Nahum, Greenspan, Joel D, Fillingim, Roger B, Ohrbach, Richard, Slade, Gary D, Knott, Charles, Dubner, Ronald, Nackley, Andrea G, Ribeiro-da-Silva, Alfredo, Neely, G Gregory, Maixner, William, Zaykin, Dmitri V, Mogil, Jeffrey S, Diatchenko, Luda

“…The EGFR belongs to the well-studied ErbB family of receptor tyrosine kinases. EGFR is activated by numerous endogenous ligands that promote cellular growth,…”
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Development of PainFace software to simplify, standardize, and scale up mouse grimace analyses by McCoy, Eric S, Park, Sang Kyoon, Patel, Rahul P, Ryan, Dan F, Mullen, Zachary J, Nesbitt, Jacob J, Lopez, Josh E, Taylor-Blake, Bonnie, Vanden, Kelly A, Krantz, James L, Hu, Wenxin, Garris, Rosanna L, Snyder, Magdalyn G, Lima, Lucas V, Sotocinal, Susana G, Austin, Jean-Sebastien, Kashlan, Adam D, Shah, Sanya, Trocinski, Abigail K, Pudipeddi, Samhitha S, Major, Rami M, Bazick, Hannah O, Klein, Morgan R, Mogil, Jeffrey S, Wu, Guorong, Zylka, Mark J

“…Facial grimacing is used to quantify spontaneous pain in mice and other mammals, but scoring relies on humans with different levels of proficiency. Here, we…”
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Effect of Human Genetic Variability on Gene Expression in Dorsal Root Ganglia and Association with Pain Phenotypes by Parisien, Marc, Khoury, Samar, Chabot-Doré, Anne-Julie, Sotocinal, Susana G., Slade, Gary D., Smith, Shad B., Fillingim, Roger B., Ohrbach, Richard, Greenspan, Joel D., Maixner, William, Mogil, Jeffrey S., Belfer, Inna, Diatchenko, Luda

“…Dorsal root ganglia (DRG) relay sensory information to the brain, giving rise to the perception of pain, disorders of which are prevalent and burdensome. Here,…”
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Development of PainFace software to simplify, standardize, and scale up mouse grimace analyses by McCoy, Eric S, Park, Sang Kyoon, Patel, Rahul P, Ryan, Dan F, Mullen, Zachary J, Nesbitt, Jacob J, Lopez, Josh E, Taylor-Blake, Bonnie, Vanden, Kelly A, Krantz, James L, Hu, Wenxin, Garris, Rosanna L, Snyder, Magdalyn G, Lima, Lucas V, Sotocinal, Susana G, Austin, Jean-Sebastien, Kashlan, Adam D, Shah, Sanya, Trocinski, Abigail K, Pudipeddi, Samhitha S, Major, Rami M, Bazick, Hannah O, Klein, Morgan R, Mogil, Jeffrey S, Wu, Guorong, Zylka, Mark J

“…Facial grimacing is used to quantify spontaneous pain in mice and other mammals, but scoring relies on humans with different levels of proficiency. Here, we…”
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Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition by Kahle, Kristopher T, Schmouth, Jean-François, Lavastre, Valérie, Latremoliere, Alban, Zhang, Jinwei, Andrews, Nick, Omura, Takao, Laganière, Janet, Rochefort, Daniel, Hince, Pascale, Castonguay, Geneviève, Gaudet, Rébecca, Mapplebeck, Josiane C S, Sotocinal, Susana G, Duan, JingJing, Ward, Catherine, Khanna, Arjun R, Mogil, Jeffrey S, Dion, Patrick A, Woolf, Clifford J, Inquimbert, Perrine, Rouleau, Guy A

“…HSN2is a nervous system predominant exon of the gene encoding the kinase WNK1 and is mutated in an autosomal recessive, inherited form of congenital pain…”
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Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity by Tansley, Shannon N., Macintyre, Leigh C., Diamond, Laura, Sotocinal, Susana G., George, Nicole, Meluban, Lee, Austin, Jean-Sebastien, Coderre, Terence J., Martin, Loren J., Mogil, Jeffrey S.

“…The counterirritation phenomenon known as conditioned pain modulation, or diffuse noxious inhibitory control in animals, is of increasing interest due to its…”
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Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociception by Szabo, Nora E, da Silva, Ronan V, Sotocinal, Susana G, Zeilhofer, Hanns Ulrich, Mogil, Jeffrey S, Kania, Artur

“…Spinal cord neurons respond to peripheral noxious stimuli and relay this information to higher brain centers, but the molecules controlling the assembly of…”
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Using the Mouse Grimace Scale to Reevaluate the Efficacy of Postoperative Analgesics in Laboratory Mice by Matsumiya, Lynn C, Sorge, Robert E, Sotocinal, Susana G, Tabaka, John M, Wieskopf, Jeffrey S, Zaloum, Austin, King, Oliver D, Mogil, Jeffrey S

“…Postoperative pain management in animals is complicated greatly by the inability to recognize pain. As a result, the choice of analgesics and their doses has…”
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