Search Results - "Sosunov, A A"

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease by Fang, Fang, Zhang, Hong, Yan, Shi Du, Arancio, Ottavio, Chen, Doris, Yan, Yilin, Gunn-Moore, Frank J, Molkentin, Jeffery D, Guo, Lan, Vonsattel, Jean Paul, Wang, Chunyu, M McKhann, Guy, Chen, John Xi, Du, Heng, A Sosunov, Alexander

“…Mitochondrial dysfunction has been described in Alzheimer's disease, but how it is induced has remained unclear. Shi Du Yan and her colleagues find that a…”
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pH (low) insertion peptide (pHLIP) targets ischemic myocardium by Sosunov, Eugene A., Anyukhovsky, Evgeny P., Sosunov, Alexander A., Moshnikova, Anna, Wijesinghe, Dayanjali, Engelman, Donald M., Reshetnyak, Yana K., Andreev, Oleg A.

“…The pH (low) insertion peptide (pHLIP) family enables targeting of cells in tissues with low extracellular pH. Here, we show that ischemic myocardium is…”
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Early deficits in synaptic mitochondria in an Alzheimer’s disease mouse model by Du, Heng, Guo, Lan, Yan, Shiqiang, Sosunov, Alexander A., McKhann, Guy M., Yan, Shirley ShiDu, Cuatrecasas, Pedro M.

“…Synaptic dysfunction and the loss of synapses are early pathological features of Alzheimer’s disease (AD). Synapses are sites of high energy demand and…”
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Single-nucleus RNA-seq identifies Huntington disease astrocyte states by Al-Dalahmah, Osama, Sosunov, Alexander A, Shaik, A, Ofori, Kenneth, Liu, Yang, Vonsattel, Jean Paul, Adorjan, Istvan, Menon, Vilas, Goldman, James E

“…Huntington Disease (HD) is an inherited movement disorder caused by expanded CAG repeats in the Huntingtin gene. We have used single nucleus RNASeq (snRNASeq)…”
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Drp1-mediated mitochondrial abnormalities link to synaptic injury in diabetes model by Huang, Shengbin, Wang, Yongfu, Gan, Xueqi, Fang, Du, Zhong, Changjia, Wu, Long, Hu, Gang, Sosunov, Alexander A, McKhann, Guy M, Yu, Haiyang, Yan, Shirley ShiDu

“…Diabetes has adverse effects on the brain, especially the hippocampus, which is particularly susceptible to synaptic injury and cognitive dysfunction. The…”
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Phenotypic heterogeneity and plasticity of isocortical and hippocampal astrocytes in the human brain by Sosunov, Alexander A, Wu, Xiaoping, Tsankova, Nadejda M, Guilfoyle, Eileen, McKhann, 2nd, Guy M, Goldman, James E

“…To examine the diversity of astrocytes in the human brain, we immunostained surgical specimens of temporal cortex and hippocampus and autopsy brains for CD44,…”
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in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus by Pereira, Ana C, Huddleston, Dan E, Brickman, Adam M, Sosunov, Alexander A, Hen, Rene, McKhann, Guy M, Sloan, Richard, Gage, Fred H, Brown, Truman R, Small, Scott A

“…With continued debate over the functional significance of adult neurogenesis, identifying an in vivo correlate of neurogenesis has become an important goal…”
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High Dietary Advanced Glycation End Products Impair Mitochondrial and Cognitive Function by Akhter, Firoz, Chen, Doris, Akhter, Asma, Sosunov, Alexander A, Chen, Allen, McKhann, Guy M, Yan, Shi Fang, Yan, Shirley ShiDu

“…Advanced glycation end products (AGEs) are an important risk factor for the development of cognitive decline in aging and late-onset neurodegenerative diseases…”
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DHA but Not EPA Emulsions Preserve Neurological and Mitochondrial Function after Brain Hypoxia-Ischemia in Neonatal Mice by Mayurasakorn, Korapat, Niatsetskaya, Zoya V, Sosunov, Sergey A, Williams, Jill J, Zirpoli, Hylde, Vlasakov, Iliyan, Deckelbaum, Richard J, Ten, Vadim S

“…Treatment with triglyceride emulsions of docosahexaenoic acid (tri-DHA) protected neonatal mice against hypoxia-ischemia (HI) brain injury. The mechanism of…”
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Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease by Sosunov, Alexander A, Guilfoyle, Eileen, Wu, Xiaoping, McKhann, 2nd, Guy M, Goldman, James E

“…Alexander Disease (AxD) is a primary disorder of astrocytes, caused by heterozygous mutations in GFAP, which encodes the major astrocyte intermediate filament…”
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Spinal Cord Endoplasmic Reticulum Stress Associated with a Microsomal Accumulation of Mutant Superoxide Dismutase-1 in an ALS Model by Kikuchi, Hitoshi, Almer, Gabriele, Yamashita, Satoshi, Guégan, Christelle, Nagai, Makiko, Xu, Zuoshang, Sosunov, Alexander A., McKhann, Guy M., Przedborski, Serge

“…Mutation in superoxide dismutase-1 (SOD1), which is a cause of ALS, alters the folding patterns of this protein. Accumulation of misfolded mutant SOD1 might…”
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Application of blebbistatin as an excitation–contraction uncoupler for electrophysiologic study of rat and rabbit hearts by Fedorov, Vadim V., PhD, Lozinsky, Ilya T., PhD, Sosunov, Eugene A., PhD, Anyukhovsky, Evgeniy P., PhD, Rosen, Michael R., MD, Balke, C. William, MD, PhD, Efimov, Igor R., PhD

“…Background Application of fluorescence imaging of cardiac electrical activity is limited by motion artifacts and/or side effects of currently available…”
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Omega-3 fatty acid diglyceride emulsions as a novel injectable acute therapeutic in neonatal hypoxic-ischemic brain injury by Zirpoli, Hylde, Bernis, Maria Eugenia, Sabir, Hemmen, Manual Kollareth, Denny Joseph, Hamilton, James A., Huang, Nasi, Ng, Jesse, Sosunov, Sergey A., Gaebler, Ben, Ten, Vadim S., Deckelbaum, Richard J.

“…Hypoxic-ischemic encephalopathy (HIE), resulting from a lack of blood flow and oxygen before or during newborn delivery, is a leading cause of cerebral palsy…”
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The impact of various factors on the surface of X-cut lithium niobate and properties of proton-exchanged waveguides by Sosunov, A. V., Petukhov, I. V., Kichigin, V. I., Ponomarev, R. S., Mololkin, A. A., Kuneva, M.

“…This work describes the effects of various impacts (thermal, plasma, chemical) on X-cut lithium niobate surface and on the structure and optical…”
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Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease by Heaven, Michael R, Flint, Daniel, Randall, Shan M, Sosunov, Alexander A, Wilson, Landon, Barnes, Stephen, Goldman, James E, Muddiman, David C, Brenner, Michael

“…Alexander disease (AxD) is a neurodegenerative disorder characterized by astrocytic protein aggregates called Rosenthal fibers (RFs). We used mouse models of…”
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Alexander Disease Mutant Glial Fibrillary Acidic Protein Compromises Glutamate Transport in Astrocytes by Tian, Rujin, Wu, Xiaoping, Hagemann, Tracy L, Sosunov, Alexandre A, Messing, Albee, McKhann, Guy M, Goldman, James E

“…Alexander disease (AxD) is a leukodystrophy caused by heterozygous mutations in the gene for glial fibrillary acidic protein, an intermediate filament protein…”
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Ex vivo multi-electrode analysis reveals spatiotemporal dynamics of ictal behavior at the infiltrated margin of glioma by Gill, Brian J.A., Wu, Xiaoping, Khan, Farhan A., Sosunov, Alexander A., Liou, Jyun-you, Dovas, Athanassios, Eissa, Tahra L., Banu, Matei A., Bateman, Lisa M., McKhann, Guy M., Canoll, Peter, Schevon, Catherine

“…The purpose of this study is to develop a platform in which the cellular and molecular underpinnings of chronic focal neocortical lesional epilepsy can be…”
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Influence of Thermal Pretreatment of Lithium Niobate Plates on the Characteristics of Proton-Exchange Waveguides by Sosunov, A. V., Petukhov, I. V., Zhuravlev, Alexander A., Ponomarev, R. S., Mololkin, A. A., Kuneva, M.

“…A complex study of the influence of the thermal pretreatment of X cut lithium niobate plates (JSC Fomos-Materials, Russia) on the formation of proton-exchange…”
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The complement cascade as a therapeutic target in intracerebral hemorrhage by Ducruet, Andrew F., Zacharia, Brad E., Hickman, Zachary L., Grobelny, Bartosz T., Yeh, Mason L., Sosunov, Sergey A., Connolly, E. Sander

“…Intracerebral hemorrhage (ICH) is the second most common and deadliest form of stroke. Currently, no pharmacologic treatment strategies exist for this…”
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Pseudocapacitance of Microporous Carbon/Polyaniline Composites by Sosunov, A. V., Rajapakse, Manthila, Rudakov, G. A., Ponomarev, R. S., Henner, V. K., Jasinski, Jacek B., Buchberger, Dominika A., Reza, Md. Shamim, Karki, Bhupendra, Sumanasekera, Gamini

“…High capacity (>200 F/g) supercapacitor electrodes have been fabricated by blending high surface area microporous carbon and polyaniline. The incorporation of…”
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