Search Results - "Sossi, Vesna"

Resolution modeling in PET imaging: Theory, practice, benefits, and pitfalls by Rahmim, Arman, Qi, Jinyi, Sossi, Vesna

“…In this paper, the authors review the field of resolution modeling in positron emission tomography (PET) image reconstruction, also referred to as…”
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Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson's disease by Whone, Alan, Luz, Matthias, Boca, Mihaela, Woolley, Max, Mooney, Lucy, Dharia, Sonali, Broadfoot, Jack, Cronin, David, Schroers, Christian, Barua, Neil U, Longpre, Lara, Barclay, C Lynn, Boiko, Chris, Johnson, Greg A, Fibiger, H Christian, Harrison, Rob, Lewis, Owen, Pritchard, Gemma, Howell, Mike, Irving, Charlie, Johnson, David, Kinch, Suk, Marshall, Christopher, Lawrence, Andrew D, Blinder, Stephan, Sossi, Vesna, Stoessl, A Jon, Skinner, Paul, Mohr, Erich, Gill, Steven S

“…Trials of GDNF in Parkinson's disease have yielded inconsistent results. In a randomised controlled trial, Whone et al. administer GDNF using a paradigm…”
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Comparison of Invasive and Non-invasive Estimation of [11C]PBR28 Binding in Non-human Primates by Aceves-Serrano, Lucero, Sossi, Vesna, Doudet, Doris J.

“…Purpose To identify a reliable alternative to the full blood [ 11 C]PBR28 quantification method that would be easily replicated in multiple research and…”
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Performance of a PET Insert for High-Resolution Small-Animal PET/MRI at 7 Tesla by Stortz, Greg, Thiessen, Jonathan D, Bishop, Daryl, Khan, Muhammad Salman, Kozlowski, Piotr, Retière, Fabrice, Schellenberg, Graham, Shams, Ehsan, Zhang, Xuezhu, Thompson, Christopher J, Goertzen, Andrew L, Sossi, Vesna

“…We characterize a compact MR-compatible PET insert for simultaneous preclinical PET/MRI. Although specifically designed with the strict size constraint to fit…”
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Homozygous alpha-synuclein p.A53V in familial Parkinson’s disease by Yoshino, Hiroyo, PhD, Hirano, Makito, MD, PhD, Stoessl, A. Jon, MD, Imamichi, Yoko, BS, Ikeda, Aya, MD, Li, Yuanzhe, MD, PhD, Funayama, Manabu, PhD, Yamada, Ikuko, MD, PhD, Nakamura, Yusaku, MD, PhD, Sossi, Vesna, PhD, Farrer, Matthew J., PhD, Nishioka, Kenya, MD, PhD, Hattori, Nobutaka, MD, PhD

“…Abstract We have assessed the frequency of alpha-synuclein ( SNCA ) mutations in Japanese patients with familial or sporadic Parkinson’s disease (PD), and…”
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Improved prediction of outcome in Parkinson's disease using radiomics analysis of longitudinal DAT SPECT images by Rahmim, Arman, Huang, Peng, Shenkov, Nikolay, Fotouhi, Sima, Davoodi-Bojd, Esmaeil, Lu, Lijun, Mari, Zoltan, Soltanian-Zadeh, Hamid, Sossi, Vesna

“…No disease modifying therapies for Parkinson's disease (PD) have been found effective to date. To properly power clinical trials for discovery of such…”
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Quantitative PET in the 2020s: a roadmap by Meikle, Steven R, Sossi, Vesna, Roncali, Emilie, Cherry, Simon R, Banati, Richard, Mankoff, David, Jones, Terry, James, Michelle, Sutcliffe, Julie, Ouyang, Jinsong, Petibon, Yoann, Ma, Chao, El Fakhri, Georges, Surti, Suleman, Karp, Joel S, Badawi, Ramsey D, Yamaya, Taiga, Akamatsu, Go, Schramm, Georg, Rezaei, Ahmadreza, Nuyts, Johan, Fulton, Roger, Kyme, André, Lois, Cristina, Sari, Hasan, Price, Julie, Boellaard, Ronald, Jeraj, Robert, Bailey, Dale L, Eslick, Enid, Willowson, Kathy P, Dutta, Joyita

“…Positron emission tomography (PET) plays an increasingly important role in research and clinical applications, catalysed by remarkable technical advances and a…”
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Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies by Wile, Daryl J, Dr, Agarwal, Pankaj A, DM, Schulzer, Michael, Prof, Mak, Edwin, BASc, Dinelle, Katherine, MSc, Shahinfard, Elham, PhD, Vafai, Nasim, MASc, Hasegawa, Kazuko, PhD, Zhang, Jing, Prof, McKenzie, Jessamyn, LPN, Neilson, Nicole, RN, Strongosky, Audrey, BA, Uitti, Ryan J, Prof, Guttman, Mark, MD, Zabetian, Cyrus P, MD, Ding, Yu-Shin, Prof, Adam, Mike, PhD, Aasly, Jan, Prof, Wszolek, Zbigniew K, Prof, Farrer, Matthew, Prof, Sossi, Vesna, Prof, Stoessl, A Jon, Prof

“…Summary Background People with Parkinson's disease can show premotor neurochemical changes in the dopaminergic and non-dopaminergic systems. Using PET, we…”
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Optimized machine learning methods for prediction of cognitive outcome in Parkinson's disease by Salmanpour, Mohammad R., Shamsaei, Mojtaba, Saberi, Abdollah, Setayeshi, Saeed, Klyuzhin, Ivan S., Sossi, Vesna, Rahmim, Arman

“…Given the increasing recognition of the significance of non-motor symptoms in Parkinson's disease, we investigate the optimal use of machine learning methods…”
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PBB3 imaging in Parkinsonian disorders: Evidence for binding to tau and other proteins by Perez‐Soriano, Alexandra, Arena, Julieta E., Dinelle, Katie, Miao, Qing, McKenzie, Jessamyn, Neilson, Nicole, Puschmann, Andreas, Schaffer, Paul, Shinotoh, Hitoshi, Smith‐Forrester, Jenna, Shahinfard, Elham, Vafai, Nasim, Wile, Daryl, Wszolek, Zbigniew, Higuchi, Makoto, Sossi, Vesna, Stoessl, A. Jon

“…ABSTRACT Background and Objectives: To study selective regional binding for tau pathology in vivo, using PET with [11C]PBB3 in PSP patients, and other…”
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DNAJC12 and dopa‐responsive nonprogressive parkinsonism by Straniero, Letizia, Guella, Ilaria, Cilia, Roberto, Parkkinen, Laura, Rimoldi, Valeria, Young, Alexander, Asselta, Rosanna, Soldà, Giulia, Sossi, Vesna, Stoessl, A. Jon, Priori, Alberto, Nishioka, Kenya, Hattori, Nobutaka, Follett, Jordan, Rajput, Alex, Blau, Nenad, Pezzoli, Gianni, Farrer, Matthew J., Goldwurm, Stefano, Rajput, Ali H., Duga, Stefano

“…Biallelic DNAJC12 mutations were described in children with hyperphenylalaninemia, neurodevelopmental delay, and dystonia. We identified DNAJC12 homozygous…”
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Differences in brain structure and cognitive performance between patients with long-COVID and those with normal recovery by Nelson, Breanna K., Farah, Lea N., Grier, Ava, Su, Wayne, Chen, Johnson, Sossi, Vesna, Sekhon, Mypinder S., Stoessl, A. Jon, Wellington, Cheryl, Honer, William G., Lang, Donna, Silverberg, Noah D., Panenka, William J.

“…•Long-COVID is heterogeneous in its symptoms, severity, and illness duration.•There was no association between long-COVID and cognitive performance.•Cognitive…”
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Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands by Innis, Robert B, Cunningham, Vincent J, Delforge, Jacques, Fujita, Masahiro, Gjedde, Albert, Gunn, Roger N, Holden, James, Houle, Sylvain, Huang, Sung-Cheng, Ichise, Masanori, Iida, Hidehiro, Ito, Hiroshi, Kimura, Yuichi, Koeppe, Robert A, Knudsen, Gitte M, Knuuti, Juhani, Lammertsma, Adriaan A, Laruelle, Marc, Logan, Jean, Maguire, Ralph Paul, Mintun, Mark A, Morris, Evan D, Parsey, Ramin, Price, Julie C, Slifstein, Mark, Sossi, Vesna, Suhara, Tetsuya, Votaw, John R, Wong, Dean F, Carson, Richard E

“…An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding…”
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The effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of Parkinson's disease: a cross-sectional PET study by Liu, Shu-Ying, Wile, Daryl J, Fu, Jessie Fanglu, Valerio, Jason, Shahinfard, Elham, McCormick, Siobhan, Mabrouk, Rostom, Vafai, Nasim, McKenzie, Jess, Neilson, Nicole, Perez-Soriano, Alexandra, Arena, Julieta E, Cherkasova, Mariya, Chan, Piu, Zhang, Jing, Zabetian, Cyrus P, Aasly, Jan O, Wszolek, Zbigniew K, McKeown, Martin J, Adam, Michael J, Ruth, Thomas J, Schulzer, Michael, Sossi, Vesna, Stoessl, A Jon

“…Markers of neuroinflammation are increased in some patients with LRRK2 Parkinson's disease compared with individuals with idiopathic Parkinson's disease,…”
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Brain microglia activation and peripheral adaptive immunity in Parkinson’s disease: a multimodal PET study by Liu, Shu-Ying, Qiao, Hong-Wen, Song, Tian-Bin, Liu, Xiu-Lin, Yao, Yun-Xia, Zhao, Chun-Song, Barret, Olivier, Xu, Sheng-Li, Cai, Yan-Ning, Tamagnan, Gilles D, Sossi, Vesna, Lu, Jie, Chan, Piu

“…Abstract Background Abnormal activation of immune system is an important pathogenesis of Parkinson’s disease, but the relationship between peripheral…”
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Cortical morphology predicts placebo response in multiple sclerosis by Cherkasova, Mariya V., Fu, Jessie F., Jarrett, Michael, Johnson, Poljanka, Abel, Shawna, Tam, Roger, Rauscher, Alexander, Sossi, Vesna, Kolind, Shannon, Li, David K. B., Sadovnick, A. Dessa, Machan, Lindsay, Girard, J. Marc, Emond, Francois, Vosoughi, Reza, Traboulsee, Anthony, Stoessl, A. Jon

“…Despite significant insights into the neural mechanisms of acute placebo responses, less is known about longer-term placebo responses, such as those seen in…”
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Machine learning methods for optimal prediction of motor outcome in Parkinson’s disease by Salmanpour, Mohammad R., Shamsaei, Mojtaba, Saberi, Abdollah, Klyuzhin, Ivan S., Tang, Jing, Sossi, Vesna, Rahmim, Arman

“…•We explored a range of predictor machines and feature subset selector machines.•LOLIMOT was seen as the best predictor machine.•GA and ACO were the best…”
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Age-specific progression of nigrostriatal dysfunction in Parkinson's disease by de la Fuente-Fernández, Raúl, Schulzer, Michael, Kuramoto, Lisa, Cragg, Jacquelyn, Ramachandiran, Nandhagopal, Au, Wing L., Mak, Edwin, McKenzie, Jess, McCormick, Siobhan, Sossi, Vesna, Ruth, Thomas J., Lee, Chong S., Calne, Donald B., Stoessl, A. Jon

“…Objective: To investigate in vivo the impact of age on nigrostriatal dopamine dysfunction in Parkinson's disease (PD). Methods: PD patients (n = 78) and…”
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Artificial Neural Network–Based Prediction of Outcome in Parkinson’s Disease Patients Using DaTscan SPECT Imaging Features by Tang, Jing, Yang, Bao, Adams, Matthew P., Shenkov, Nikolay N., Klyuzhin, Ivan S., Fotouhi, Sima, Davoodi-Bojd, Esmaeil, Lu, Lijun, Soltanian-Zadeh, Hamid, Sossi, Vesna, Rahmim, Arman

“…Purpose Quantitative analysis of dopamine transporter (DAT) single-photon emission computed tomography (SPECT) images can enhance diagnostic confidence and…”
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First Results From a High-Resolution Small Animal SiPM PET Insert for PET/MR Imaging at 7T by Goertzen, Andrew L., Stortz, Greg, Thiessen, Jonathan D., Bishop, Daryl, Khan, Muhammad Salman, Kozlowski, Piotr, Retiere, Fabrice, Schellenberg, Graham, Shams, Ehsan, Sossi, Vesna, Thompson, Christopher J.

“…We present the initial results from a small animal PET insert designed to be operated inside a 7T MRI. The insert fits within the 114 mm inner diameter of the…”
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