Search Results - "Sosabowski, Jane K"

Translocation of LRP1 targeted carbon nanotubes of different diameters across the blood–brain barrier in vitro and in vivo by Kafa, Houmam, Wang, Julie Tzu-Wen, Rubio, Noelia, Klippstein, Rebecca, Costa, Pedro M., Hassan, Hatem A.F.M., Sosabowski, Jane K., Bansal, Sukhvinder S., Preston, Jane E., Abbott, N. Joan, Al-Jamal, Khuloud T.

“…Brain glioblastoma and neurodegenerative diseases are still largely untreated due to the inability of most drugs to cross the blood–brain barrier (BBB)…”
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Magnetically Decorated Multiwalled Carbon Nanotubes as Dual MRI and SPECT Contrast Agents by Wang, Julie Tzu-Wen, Cabana, Laura, Bourgognon, Maxime, Kafa, Houmam, Protti, Andrea, Venner, Kerrie, Shah, Ajay M., Sosabowski, Jane K., Mather, Stephen J., Roig, Anna, Ke, Xiaoxing, Van Tendeloo, Gustaaf, de Rosales, Rafael T. M., Tobias, Gerard, Al-Jamal, Khuloud T.

“…Carbon nanotubes (CNTs) are one of the most promising nanomaterials to be used in biomedicine for drug/gene delivery as well as biomedical imaging. This study…”
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18F‑Trifluoromethanesulfinate Enables Direct C–H 18F‑Trifluoromethylation of Native Aromatic Residues in Peptides by Kee, Choon Wee, Tack, Osman, Guibbal, Florian, Wilson, Thomas C, Isenegger, Patrick G, Imiołek, Mateusz, Verhoog, Stefan, Tilby, Michael, Boscutti, Giulia, Ashworth, Sharon, Chupin, Juliette, Kashani, Roxana, Poh, Adeline W. J, Sosabowski, Jane K, Macholl, Sven, Plisson, Christophe, Cornelissen, Bart, Willis, Michael C, Passchier, Jan, Davis, Benjamin G, Gouverneur, Véronique

“…18F labeling strategies for unmodified peptides with [18F]­fluoride require 18F-labeled prosthetics for bioconjugation more often with cysteine thiols or…”
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Evaluation and comparison of a new DOTA and DTPA-bombesin agonist in vitro and in vivo in low and high GRPR expressing prostate and breast tumor models by Pujatti, Priscilla B., Foster, Julie M., Finucane, Ciara, Hudson, Chantelle D., Burnet, Jerome C., Pasqualoto, Kerly F.M., Mengatti, Jair, Mather, Stephen J., de Araújo, Elaine B., Sosabowski, Jane K.

“…We evaluated and compared a new bombesin analog [Tyr–Gly5, Nle14]-BBN(6–14) conjugated to DOTA or DTPA and radiolabeled with In-111 in low and high GRPR…”
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High-throughput high-volume nuclear imaging for preclinical in vivo compound screening by Macholl, Sven, Finucane, Ciara M., Hesterman, Jacob, Mather, Stephen J., Pauplis, Rachel, Scully, Deirdre, Sosabowski, Jane K., Jouannot, Erwan

“…Background Preclinical single-photon emission computed tomography (SPECT)/CT imaging studies are hampered by low throughput, hence are found typically within…”
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Anesthesia and Monitoring of Animals During MRI Studies by Tremoleda, Jordi L, Macholl, Sven, Sosabowski, Jane K

“…The use of imaging represents a major impact on the refinement and the reduction of in vivo studies in animal models, in particular for allowing longitudinal…”
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Site-specific stabilization of minigastrin analogs against enzymatic degradation for enhanced cholecystokinin-2 receptor targeting by Klingler, Maximilian, Decristoforo, Clemens, Rangger, Christine, Summer, Dominik, Foster, Julie, Sosabowski, Jane K, von Guggenberg, Elisabeth

“…Minigastrin (MG) analogs show high affinity to the cholecystokinin-2 receptor (CCK2R) and have therefore been intensively studied to find a suitable analog for…”
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Selection of radionuclide(s) for targeted alpha therapy based on their nuclear decay properties by Ree, Samantha M, Greenwood, Howard, Young, Jennifer D, Roberts, Rachel F C, Livens, Francis R, Heath, Scott L, Sosabowski, Jane K

“…Targeted alpha therapy (TAT) is a promising form of oncology treatment utilising alpha-emitting radionuclides that can specifically accumulate at disease…”
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Preclinical in vivo modeling of cytokine release syndrome induced by ErbB-retargeted human T cells: identifying a window of therapeutic opportunity? by van der Stegen, Sjoukje J C, Davies, David M, Wilkie, Scott, Foster, Julie, Sosabowski, Jane K, Burnet, Jerome, Whilding, Lynsey M, Petrovic, Roseanna M, Ghaem-Maghami, Sadaf, Mather, Stephen, Jeannon, Jean-Pierre, Parente-Pereira, Ana C, Maher, John

“…The ErbB network is dysregulated in many solid tumors. To exploit this, we have developed a chimeric Ag receptor (CAR) named T1E28z that targets several…”
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The relationship between the diameter of chemically-functionalized multi-walled carbon nanotubes and their organ biodistribution profiles in vivo by Wang, Julie T-W, Fabbro, Chiara, Venturelli, Enrica, Ménard-Moyon, Cécilia, Chaloin, Olivier, Da Ros, Tatiana, Methven, Laura, Nunes, Antonio, Sosabowski, Jane K, Mather, Stephen J, Robinson, Martyn K, Amadou, Julien, Prato, Maurizio, Bianco, Alberto, Kostarelos, Kostas, Al-Jamal, Khuloud T

“…Abstract Carbon nanotubes (CNTs) exhibit unique properties which have led to their applications in the biomedical field as novel delivery systems for diagnosis…”
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Kinetics of functionalised carbon nanotube distribution in mouse brain after systemic injection: Spatial to ultra-structural analyses by Wang, Julie T.-W., Rubio, Noelia, Kafa, Houmam, Venturelli, Enrica, Fabbro, Chiara, Ménard-Moyon, Cécilia, Da Ros, Tatiana, Sosabowski, Jane K., Lawson, Alastair D., Robinson, Martyn K., Prato, Maurizio, Bianco, Alberto, Festy, Frederic, Preston, Jane E., Kostarelos, Kostas, Al-Jamal, Khuloud T.

“…Earlier studies proved the success of using chemically functionalised multi-walled carbon nanotubes (f-MWNTs) as nanocarriers to the brain. Little insight into…”
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Investigating in vitro and in vivo αvβ6 integrin receptor-targeting liposomal alendronate for combinatory γδ T cell immunotherapy by Hodgins, Naomi O., Al-Jamal, Wafa' T., Wang, Julie T.-W., Klippstein, Rebecca, Costa, Pedro M., Sosabowski, Jane K., Marshall, John F., Maher, John, Al-Jamal, Khuloud T.

“…The αvβ6 integrin receptor has been shown to be overexpressed on many types of cancer cells, resulting in a more pro-invasive and aggressive phenotype, this…”
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Radiolabelled peptides for oncological diagnosis by Laverman, Peter, Sosabowski, Jane K., Boerman, Otto C., Oyen, Wim J. G.

“…Radiolabelled receptor-binding peptides targeting receptors (over)expressed on tumour cells are widely under investigation for tumour diagnosis and therapy…”
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Adoptive Immunotherapy of Epithelial Ovarian Cancer with V gamma 9V delta 2 T Cells, Potentiated by Liposomal Alendronic Acid by Parente-Pereira, Ana C, Shmeeda, Hilary, Whilding, Lynsey M, Zambirinis, Constantinos P, Foster, Julie, van der Stegen, Sjoukje JC, Beatson, Richard, Zabinski, Tomasz, Brewig, Nancy, Sosabowski, Jane K, Mather, Stephen, Ghaem-Maghami, Sadaf, Gabizon, Alberto, Maher, John

“…Adoptive immunotherapy using gamma delta T cells harnesses their natural role in tumor immunosurveillance. The efficacy of this approach is enhanced by…”
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Engineering hepatitis B virus core particles for targeting HER2 receptors in vitro and in vivo by Suffian, Izzat Fahimuddin Bin Mohamed, Wang, Julie Tzu-Wen, Hodgins, Naomi O, Martin, Rebecca Klippstein, Garcia-Maya, Mitla, Brown, Paul, Nishimura, Yuya, Heidari, Hamed, Bals, Sara, Sosabowski, Jane, Ogino, Chiaki, Kondo, Akihiko, Al-Jamal, Khuloud T

“…Abstract Hepatitis B Virus core (HBc) particles have been studied for their potential as drug delivery vehicles for cancer therapy. HBc particles are hollow…”
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Adoptive immunotherapy of epithelial ovarian cancer with Vγ9Vδ2 T cells, potentiated by liposomal alendronic acid by Parente-Pereira, Ana C, Shmeeda, Hilary, Whilding, Lynsey M, Zambirinis, Constantinos P, Foster, Julie, van der Stegen, Sjoukje J C, Beatson, Richard, Zabinski, Tomasz, Brewig, Nancy, Sosabowski, Jane K, Mather, Stephen, Ghaem-Maghami, Sadaf, Gabizon, Alberto, Maher, John

“…Adoptive immunotherapy using γδ T cells harnesses their natural role in tumor immunosurveillance. The efficacy of this approach is enhanced by…”
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Neutron Activated 153 Sm Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy by Wang, Julie T-W, Klippstein, Rebecca, Martincic, Markus, Pach, Elzbieta, Feldman, Robert, Šefl, Martin, Michel, Yves, Asker, Daniel, Sosabowski, Jane K, Kalbac, Martin, Da Ros, Tatiana, Ménard-Moyon, Cécilia, Bianco, Alberto, Kyriakou, Ioanna, Emfietzoglou, Dimitris, Saccavini, Jean-Claude, Ballesteros, Belén, Al-Jamal, Khuloud T, Tobias, Gerard

“…Radiation therapy along with chemotherapy and surgery remain the main cancer treatments. Radiotherapy can be applied to patients externally (external beam…”
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Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 by Ocak, Meltem, Helbok, Anna, Rangger, Christine, Peitl, Petra Kolenc, Nock, Berthold A., Morelli, Giancarlo, Eek, Annemarie, Sosabowski, Jane K., Breeman, Wout A. P., Reubi, Jean Claude, Decristoforo, Clemens

“…Purpose Stability of radiolabelled cholecystokinin 2 (CCK2) receptor targeting peptides has been a major limitation in the use of such radiopharmaceuticals…”
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18 F-Trifluoromethanesulfinate Enables Direct C-H 18 F-Trifluoromethylation of Native Aromatic Residues in Peptides by Kee, Choon Wee, Tack, Osman, Guibbal, Florian, Wilson, Thomas C, Isenegger, Patrick G, Imiołek, Mateusz, Verhoog, Stefan, Tilby, Michael, Boscutti, Giulia, Ashworth, Sharon, Chupin, Juliette, Kashani, Roxana, Poh, Adeline W J, Sosabowski, Jane K, Macholl, Sven, Plisson, Christophe, Cornelissen, Bart, Willis, Michael C, Passchier, Jan, Davis, Benjamin G, Gouverneur, Véronique

“…F labeling strategies for unmodified peptides with [ F]fluoride require F-labeled prosthetics for bioconjugation more often with cysteine thiols or lysine…”
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AGR2, a unique tumor-associated antigen, is a promising candidate for antibody targeting by Liu, Alvin Y, Kanan, Adelle D, Radon, Tomasz P, Shah, Siama, Weeks, Mark E, Foster, Julie M, Sosabowski, Jane K, Dumartin, Laurent, Crnogorac-Jurcevic, Tatjana

“…Anterior gradient 2 (AGR2), a protein disulfide isomerase, shows two subcellular localizations: intracellular (iAGR2) and extracellular (eAGR2). In healthy…”
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