Search Results - "Sosa‐Peinado, Alejandro"

Thermodynamic and kinetic analysis of the LAO binding protein and its isolated domains reveal non-additivity in stability, folding and function by Vergara, Renan, Berrocal, Tania, Juárez Mejía, Eva Isela, Romero-Romero, Sergio, Velázquez-López, Isabel, Pulido, Nancy O, López Sanchez, Haven A, Silva, Daniel-Adriano, Costas, Miguel, Rodríguez-Romero, Adela, Rodríguez-Sotres, Rogelio, Sosa-Peinado, Alejandro, Fernández-Velasco, D Alejandro

“…Substrate-binding proteins (SBPs) are used by organisms from the three domains of life for transport and signalling. SBPs are composed of two domains that…”
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Redesign of LAOBP to bind novel l‐amino acid ligands by Banda‐Vázquez, Jesús, Shanmugaratnam, Sooruban, Rodríguez‐Sotres, Rogelio, Torres‐Larios, Alfredo, Höcker, Birte, Sosa‐Peinado, Alejandro

“…Computational protein design is still a challenge for advancing structure‐function relationships. While recent advances in this field are promising, more…”
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The interplay of protein–ligand and water‐mediated interactions shape affinity and selectivity in the LAO binding protein by Vergara, Renan, Romero‐Romero, Sergio, Velázquez‐López, Isabel, Espinoza‐Pérez, Georgina, Rodríguez‐Hernández, Annia, Pulido, Nancy O., Sosa‐Peinado, Alejandro, Rodríguez‐Romero, Adela, Fernández‐Velasco, Daniel Alejandro

“…The study of binding thermodynamics is essential to understand how affinity and selectivity are acquired in molecular complexes. Periplasmic binding proteins…”
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A role for both conformational selection and induced fit in ligand binding by the LAO protein by Silva, Daniel-Adriano, Bowman, Gregory R, Sosa-Peinado, Alejandro, Huang, Xuhui

“…Molecular recognition is determined by the structure and dynamics of both a protein and its ligand, but it is difficult to directly assess the role of each of…”
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Protein tyrosine phosphatase 1B (PTP1B) function, structure, and inhibition strategies to develop antidiabetic drugs by Coronell‐Tovar, Andrea, Pardo, Juan P., Rodríguez‐Romero, Adela, Sosa‐Peinado, Alejandro, Vásquez‐Bochm, Luz, Cano‐Sánchez, Patricia, Álvarez‐Añorve, Laura Iliana, González‐Andrade, Martin

“…Tyrosine protein phosphatase non‐receptor type 1 (PTP1B; also known as protein tyrosine phosphatase 1B) is a member of the protein tyrosine phosphatase (PTP)…”
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Bisindolylmaleimides New Ligands of CaM Protein by Sosa-Peinado, Alejandro, Fructuoso-García, Karina, Vásquez-Bochm, L. X., González-Andrade, Martin

“…In the present study, we reported the interactions at the molecular level of a series of compounds called Bisindolylmaleimide, as potential inhibitors of the…”
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Catalase evolved to concentrate H2O2 at its active site by Domínguez, Laura, Sosa-Peinado, Alejandro, Hansberg, Wilhelm

“…Catalase is a homo-tetrameric enzyme that has its heme active site deeply buried inside the protein. Its only substrate, hydrogen peroxide (H2O2), reaches the…”
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How catalase recognizes H2O2 in a sea of water by Domínguez, Laura, Sosa-Peinado, Alejandro, Hansberg, Wilhelm

“…ABSTRACT Monofunctional heme‐catalases have been studied for many decades but there is still an incomplete understanding of why such a large tetrameric protein…”
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Application of a Fluorescent Biosensor in Determining the Binding of 5-HT to Calmodulin by Vásquez-Bochm, L. X., Velázquez-López, Isabel, Mata, Rachel, Sosa-Peinado, Alejandro, Cano-Sánchez, Patricia, González-Andrade, Martin

“…Here, we show the utility of the fluorescent biosensor hCaM-M124C-mBBr in detecting and determining the affinity of serotonin (5-HT). We obtained a Kd of 5-HT…”
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Conformational dynamics of L-lysine, L-arginine, L-ornithine binding protein reveals ligand-dependent plasticity by Silva, Daniel-Adriano, Domínguez-Ramírez, Lenin, Rojo-Domínguez, Arturo, Sosa-Peinado, Alejandro

“…The molecular basis of multiple ligand binding affinity for amino acids in periplasmic binding proteins (PBPs) and in the homologous domain for class C…”
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On the molecular basis of the high affinity binding of basic amino acids to LAOBP, a periplasmic binding protein from Salmonella typhimurium by Pulido, Nancy O., Silva, Daniel-Adriano, Tellez, Luis A., Pérez-Hernández, Gerardo, García-Hernández, Enrique, Sosa-Peinado, Alejandro, Fernández-Velasco, D. Alejandro

“…The rational designing of binding abilities in proteins requires an understanding of the relationship between structure and thermodynamics. However, our…”
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Importance of the interaction protein-protein of the CaM-PDE1A and CaM-MLCK complexes in the development of new anti-CaM drugs by González-Andrade, Martin, Mata, Rachel, Madariaga-Mazón, Abraham, Rodríguez-Sotres, Rogelio, del Pozo-Yauner, Luis, Sosa-Peinado, Alejandro

“…Protein–protein interactions play central roles in physiological and pathological processes. The bases of the mechanisms of drug action are relevant to the…”
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Calmodulin Inhibitors from Aspergillus stromatoides by González-Andrade, Martín, Del Valle, Paulina, Macías-Rubalcava, Martha ;L., Sosa-Peinado, Alejandro, Del Carmen González, María, Mata, Rachel

“…An organic extract was prepared from the culture medium and mycelia of the marine fungus Aspergillus stromatoides Raper & Fennell. The extract was fractionated…”
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How catalase recognizes H 2 O 2 in a sea of water: How Catalase Recognizes H 2 O 2 in a Sea of Water by Domínguez, Laura, Sosa-Peinado, Alejandro, Hansberg, Wilhelm

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How catalase recognizes H sub(2)O sub(2) in a sea of water by Dominguez, Laura, Sosa-Peinado, Alejandro, Hansberg, Wilhelm

“…Monofunctional heme-catalases have been studied for many decades but there is still an incomplete understanding of why such a large tetrameric protein with…”
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Alterations in plasma membrane promote overexpression and increase of sodium influx through epithelial sodium channel in hypertensive platelets by Cerecedo, D., Martínez-Vieyra, Ivette, Sosa-Peinado, Alejandro, Cornejo-Garrido, Jorge, Ordaz-Pichardo, Cynthia, Benítez-Cardoza, Claudia

“…Platelets are small, anucleated cell fragments that activate in response to a wide variety of stimuli, triggering a complex series of intracellular pathways…”
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Theoretical-experimental studies of calmodulin-peptide interactions at different calcium equivalents by Sosa-Peinado, Alejandro, León-Cruz, Erika, Velázquez-López, Isabel, Matuz-Mares, Deyamira, Cano-Sánchez, Patricia, González-Andrade, Martin

“…We study the CaM-peptide interactions for four CaM-related peptides with different calcium equivalents, using the hCaM-M124C-mBBr biosensor and Molecular…”
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Enhanced expression of the Epithelial Sodium Channel in neutrophils from hypertensive patients by Reus-Chavarría, Erika, Martínez-Vieyra, Ivette, Salinas-Nolasco, Cristina, Chávez-Piña, Araceli Evangelina, Méndez-Méndez, Juan Vicente, López-Villegas, Edgar Oliver, Sosa-Peinado, Alejandro, Cerecedo, Doris

“…Hypertension (HTN), i.e. abnormally high blood pressure, is a major risk factor for heart attack, stroke, and kidney failure. The Epithelial Sodium Channel…”
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Expression of recombinant SnRK1 in E. coli. Characterization of adenine nucleotide binding to the SnRK1.1/AKINβγ-β3 complex by Maya-Bernal, José Luis, Ávila, Alejandra, Ruiz-Gayosso, Ana, Trejo-Fregoso, Ricardo, Pulido, Nancy, Sosa-Peinado, Alejandro, Zúñiga-Sánchez, Esther, Martínez-Barajas, Eleazar, Rodríguez-Sotres, Rogelio, Coello, Patricia

“…[Display omitted] •SnRK1.1 and SnRK1.2 subunits are active after being phosphorylated by SnAK2 and their activity increased by the union of the regulatory…”
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Development of the Fluorescent Biosensor h Calmodulin ( h CaM)L39C- monobromobimane ( mBBr )/V91C- mBBr , a Novel Tool for Discovering New Calmodulin Inhibitors and Detecting Calcium by González-Andrade, Martín, Rivera-Chávez, José, Sosa-Peinado, Alejandro, Figueroa, Mario, Rodríguez-Sotres, Rogelio, Mata, Rachel

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