Search Results - "Sosa, Miguel A."

A critical role for human caspase-4 in endotoxin sensitivity by Kajiwara, Yuji, Schiff, Tamar, Voloudakis, Georgios, Gama Sosa, Miguel A, Elder, Gregory, Bozdagi, Ozlem, Buxbaum, Joseph D

“…Response to endotoxins is an important part of the organismal reaction to Gram-negative bacteria and plays a critical role in sepsis and septic shock, as well…”
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Blast exposure induces post-traumatic stress disorder-related traits in a rat model of mild traumatic brain injury by Elder, Gregory A, Dorr, Nathan P, De Gasperi, Rita, Gama Sosa, Miguel A, Shaughness, Michael C, Maudlin-Jeronimo, Eric, Hall, Aaron A, McCarron, Richard M, Ahlers, Stephen T

“…Blast related traumatic brain injury (TBI) has been a major cause of injury in the wars in Iraq and Afghanistan. A striking feature of the mild TBI (mTBI)…”
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Unconventional animal models for traumatic brain injury and chronic traumatic encephalopathy by Ackermans, Nicole L., Varghese, Merina, Wicinski, Bridget, Torres, Joshua, De Gasperi, Rita, Pryor, Dylan, Elder, Gregory A., Gama Sosa, Miguel A., Reidenberg, Joy S., Williams, Terrie M., Hof, Patrick R.

“…Traumatic brain injury (TBI) is one of the main causes of death worldwide. It is a complex injury that influences cellular physiology, causes neuronal cell…”
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Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure by Dickstein, Dara L., De Gasperi, Rita, Gama Sosa, Miguel A., Perez-Garcia, Georgina, Short, Jennifer A., Sosa, Heidi, Perez, Gissel M., Tschiffely, Anna E., Dams-O’Connor, Kristen, Pullman, Mariel Y., Knesaurek, Karin, Knutsen, Andrew, Pham, Dzung L., Soleimani, Lale, Jordan, Barry D., Gordon, Wayne A., Delman, Bradley N., Shumyatsky, Gleb, Shahim, Pashtun-Poh, DeKosky, Steven T., Stone, James R., Peskind, Elaine, Blennow, Kaj, Zetterberg, Henrik, Chance, Steven A., Torso, Mario, Kostakoglu, Lale, Sano, Mary, Hof, Patrick R., Ahlers, Stephen T., Gandy, Sam, Elder, Gregory A.

“…Traumatic brain injury (TBI) is a risk factor for the later development of neurodegenerative diseases that may have various underlying pathologies. Chronic…”
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Hemovasculogenic origin of blood vessels in the developing mouse brain by Gama Sosa, Miguel A., De Gasperi, Rita, Perez, Gissel M., Hof, Patrick R., Elder, Gregory A.

“…Vascular structures in the developing brain are thought to form via angiogenesis from preformed blood vessels in the cephalic mesenchyme. Immunohistochemical…”
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Modeling human neurodegenerative diseases in transgenic systems by Gama Sosa, Miguel A., De Gasperi, Rita, Elder, Gregory A.

“…Transgenic systems are widely used to study the cellular and molecular basis of human neurodegenerative diseases. A wide variety of model organisms have been…”
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Neuronal DNA Methylation Profiling of Blast-Related Traumatic Brain Injury by Haghighi, Fatemeh, Ge, Yongchao, Chen, Sean, Xin, Yurong, Umali, Michelle U, De Gasperi, Rita, Gama Sosa, Miguel A, Ahlers, Stephen T, Elder, Gregory A

“…Long-term molecular changes in the brain resulting from blast exposure may be mediated by epigenetic changes, such as deoxyribonucleic acid (DNA) methylation,…”
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Chronic post-traumatic stress disorder-related traits in a rat model of low-level blast exposure by Perez-Garcia, Georgina, Gama Sosa, Miguel A., De Gasperi, Rita, Lashof-Sullivan, Margaret, Maudlin-Jeronimo, Eric, Stone, James R., Haghighi, Fatemeh, Ahlers, Stephen T., Elder, Gregory A.

“…•Blast-related traumatic brain injury (TBI) has been common in veterans of the recent conflicts in Iraq and Afghanistan.•Blast-related mild TBI (mTBI) has been…”
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Blast-induced "PTSD": Evidence from an animal model by Perez-Garcia, Georgina, Gama Sosa, Miguel A., De Gasperi, Rita, Tschiffely, Anna E., McCarron, Richard M., Hof, Patrick R., Gandy, Sam, Ahlers, Stephen T., Elder, Gregory A.

“…A striking observation among veterans returning from the recent conflicts in Iraq and Afghanistan has been the co-occurrence of blast-related mild traumatic…”
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Transgenic Mouse Models of Alzheimer's Disease by Elder, Gregory A., Gama Sosa, Miguel A., De Gasperi, Rita

“…Alzheimer's disease is the most common cause of senile dementia in the United States and Europe. At present, there is no effective treatment. Given the…”
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BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPTP301S mouse model of tauopathy by Perez-Garcia, Georgina, Bicak, Mesude, Haure-Mirande, Jean-Vianney, Perez, Gissel M., Otero-Pagan, Alena, Gama Sosa, Miguel A., De Gasperi, Rita, Sano, Mary, Barlow, Carrolee, Gage, Fred H., Readhead, Benjamin, Ehrlich, Michelle E., Gandy, Sam, Elder, Gregory A.

“…•BCI-838 is an mGluR2/3 receptor antagonist pro-drug.•BCI-838 rescued deficits in object recognition memory in PS19 tauopathy mice.•Treatment was effective…”
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Vascular and inflammatory factors in the pathophysiology of blast-induced brain injury by Elder, Gregory A, Gama Sosa, Miguel A, De Gasperi, Rita, Stone, James Radford, Dickstein, Dara L, Haghighi, Fatemeh, Hof, Patrick R, Ahlers, Stephen T

“…Blast-related traumatic brain injury (TBI) has received much recent attention because of its frequency in the conflicts in Iraq and Afghanistan. This renewed…”
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Animal transgenesis: an overview by Gama Sosa, Miguel A., De Gasperi, Rita, Elder, Gregory A.

“…Transgenic animals are extensively used to study in vivo gene function as well as to model human diseases. The technology for producing transgenic animals…”
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Progressive Transcriptional Changes in the Amygdala Implicate Neuroinflammation in the Effects of Repetitive Low-Level Blast Exposure in Male Rats by De Gasperi, Rita, Gama Sosa, Miguel A, Perez Garcia, Georgina S, Perez, Gissel M, Abutarboush, Rania, Kawoos, Usmah, Statz, Jonathan K, Patterson, Jacob, Hof, Patrick R, Katsel, Pavel, Cook, David G, Ahlers, Stephen T, Elder, Gregory A

“…Chronic mental health problems are common among military veterans who sustained blast-related traumatic brain injuries. The reasons for this association remain…”
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Castration causes an increase in lysosomal size and upregulation of cathepsin D expression in principal cells along with increased secretion of procathepsin D and prosaposin oligomers in adult rat epididymis by Carvelli, Lorena, Aguilera, Andrea Carolina, Zyla, Leila, Pereyra, Laura Lucía, Morales, Carlos R, Hermo, Louis, Sosa, Miguel A

“…In the epididymis, lysosomal proteins of the epithelial cells are normally targeted from the Golgi apparatus to lysosomes for degradation, although their…”
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Metabotropic Glutamate Receptor 2 Expression Is Chronically Elevated in Male Rats With Post-Traumatic Stress Disorder Related Behavioral Traits Following Repetitive Low-Level Blast Exposure by De Gasperi, Rita, Gama Sosa, Miguel A, Perez Garcia, Georgina, Perez, Gissel M, Pryor, Dylan, Morrison, Chenel L-A, Lind, Rachel, Abutarboush, Rania, Kawoos, Usmah, Statz, Jonathan K, Patterson, Jacob, Hof, Patrick R, Zhu, Carolyn W, Ahlers, Stephen T, Cook, David G, Elder, Gregory A

“…Many military veterans who experienced blast-related traumatic brain injuries in the conflicts in Iraq and Afghanistan currently suffer from chronic cognitive…”
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The human-specific CASP4 gene product contributes to Alzheimer-related synaptic and behavioural deficits by Kajiwara, Yuji, McKenzie, Andrew, Dorr, Nate, Gama Sosa, Miguel A, Elder, Gregory, Schmeidler, James, Dickstein, Dara L, Bozdagi, Ozlem, Zhang, Bin, Buxbaum, Joseph D

“…Recent studies have indicated that innate immune signalling molecules are involved in late-onset Alzheimer's disease (LOAD) risk. Amyloid beta (Aβ) accumulates…”
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Low-level blast exposure disrupts gliovascular and neurovascular connections and induces a chronic vascular pathology in rat brain by Gama Sosa, Miguel A, De Gasperi, Rita, Perez Garcia, Georgina S, Perez, Gissel M, Searcy, Courtney, Vargas, Danielle, Spencer, Alicia, Janssen, Pierce L, Tschiffely, Anna E, McCarron, Richard M, Ache, Benjamin, Manoharan, Rajaram, Janssen, William G, Tappan, Susan J, Hanson, Russell W, Gandy, Sam, Hof, Patrick R, Ahlers, Stephen T, Elder, Gregory A

“…Much concern exists over the role of blast-induced traumatic brain injury (TBI) in the chronic cognitive and mental health problems that develop in veterans…”
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Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation by Gama Sosa, Miguel A, De Gasperi, Rita, Pryor, Dylan, Perez Garcia, Georgina S, Perez, Gissel M, Abutarboush, Rania, Kawoos, Usmah, Hogg, Seth, Ache, Benjamin, Janssen, William G, Sowa, Allison, Tetreault, Timothy, Cook, David G, Tappan, Susan J, Gandy, Sam, Hof, Patrick R, Ahlers, Stephen T, Elder, Gregory A

“…Cerebral vascular injury as a consequence of blast-induced traumatic brain injury is primarily the result of blast wave-induced mechanical disruptions within…”
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Altered Ultrasonic Vocalization in Mice with a Disruption in the Foxp2 Gene by Shu, Weiguo, Cho, Julie Y., Jiang, Yuhui, Zhang, Minhua, Weisz, Donald, Elder, Gregory A., Schmeidler, James, De Gasperi, Rita, Miguel A. Gama Sosa, Rabidou, Donald, Santucci, Anthony C., Perl, Daniel, Morrisey, Edward, Buxbaum, Joseph D., Palese, Peter

“…Neurobiology of speech and language has previously been studied in the KE family, in which half of the members have severe impairment in both speech and…”
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